KR830003401A - 신규 사이클로 펩타이드, 그 약학적 제제 및 그들의 제법 - Google Patents

신규 사이클로 펩타이드, 그 약학적 제제 및 그들의 제법 Download PDF

Info

Publication number
KR830003401A
KR830003401A KR1019800002634A KR800002634A KR830003401A KR 830003401 A KR830003401 A KR 830003401A KR 1019800002634 A KR1019800002634 A KR 1019800002634A KR 800002634 A KR800002634 A KR 800002634A KR 830003401 A KR830003401 A KR 830003401A
Authority
KR
South Korea
Prior art keywords
formula
group
trp
acid addition
resulting
Prior art date
Application number
KR1019800002634A
Other languages
English (en)
Other versions
KR840000927B1 (ko
Inventor
링크 한스
시버 페터
캄버 부루노
Original Assignee
아놀드 자일러, 에른스트 알테르
시바-가이기 에이지
에른스트 알테르
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아놀드 자일러, 에른스트 알테르, 시바-가이기 에이지, 에른스트 알테르 filed Critical 아놀드 자일러, 에른스트 알테르
Publication of KR830003401A publication Critical patent/KR830003401A/ko
Application granted granted Critical
Publication of KR840000927B1 publication Critical patent/KR840000927B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음

Description

신규 사이클로 펩타이드, 그 약학적 제제 및 그들의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 구조식(III)의 선형 펩타이드를 고리화 하고, 생성된 다음 구조식(II)의 화합물의 보호그룸을 떼어 내고 필요하면 상응하는 염기를 생성된 산부가염에서 유리시키고, 또는 생성된 염기를 그의 산부가염으로 전환시키는 것을 특징으로 하여 다음 구조식(I)의 사이클릭 옥타펩타이드 및 각의 산부가염 및 컴플렉스를 제조하는 방법.
    상기에서,
    trp는 L-Trp 또는 D-Trp를 나타내는데 벤젠환은 할로겐 원자로 치환될 수 있으며,
    Gaba(Ar)는 사이클릭 하이드로카빌 라디칼로 치환된 γ-아미노부티르산 잔기를 나타내며,
    A는 ε-아미노-보호그룹 또는 수소를 나타내며,
    B는 하이드록실-보호그룹 또는 수소를 나타내는데,
    A 및 B중 하나만이 수소를 나타낼 수 있으며,
    II'는 아마이드 결합이 펩타이드환의 어느 두 인접 아미노산 잔기 사이에서 끊어진 구조식 II에 상응하는 라디칼을 나타내며,
    C는 유리하이드록실 그룹, 활성화 그룹으로 변형된 하이드록실그룹 또는 하이드라지노그룹 -NH-NH2를 나타낸다.
    * 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800002634A 1979-07-04 1980-07-03 사이클로펩타이드의 제조방법 KR840000927B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH6243/79-1 1979-07-04
CH624379 1979-07-04
CH113580 1980-02-12
CH1135/80-0 1980-02-12

Publications (2)

Publication Number Publication Date
KR830003401A true KR830003401A (ko) 1983-06-20
KR840000927B1 KR840000927B1 (ko) 1984-06-29

Family

ID=25686753

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800002634A KR840000927B1 (ko) 1979-07-04 1980-07-03 사이클로펩타이드의 제조방법

Country Status (17)

Country Link
US (1) US4328214A (ko)
EP (1) EP0023192B1 (ko)
KR (1) KR840000927B1 (ko)
AU (1) AU539499B2 (ko)
CA (1) CA1148146A (ko)
DD (1) DD152543A5 (ko)
DE (1) DE3067252D1 (ko)
DK (1) DK287680A (ko)
ES (1) ES8105698A1 (ko)
FI (1) FI802079A (ko)
GR (1) GR69319B (ko)
HU (1) HU188081B (ko)
IE (1) IE49995B1 (ko)
IL (1) IL60474A (ko)
NO (1) NO152092C (ko)
NZ (1) NZ194227A (ko)
PT (1) PT71490A (ko)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428942A (en) 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
GB8318552D0 (en) * 1983-07-08 1983-08-10 Sandoz Ltd Organic compounds
US4612302A (en) * 1983-11-14 1986-09-16 Brigham And Women's Hospital Clinical use of somatostatin analogues
US5411951A (en) * 1984-10-04 1995-05-02 Monsanto Company Prolonged release of biologically active somatotropin
US5474980A (en) * 1984-10-04 1995-12-12 Monsanto Company Prolonged release of biologically active somatotropins
ES8702440A1 (es) * 1984-10-04 1986-12-16 Monsanto Co Un procedimiento para la preparacion de una composicion de polipeptido inyectable sustancialmente no acuosa.
US5086041A (en) * 1984-10-04 1992-02-04 Monsanto Company Methods of using prolonged release somatotropin compositions
US4684716A (en) * 1984-12-14 1987-08-04 Smithkline Beckman Corporation Polypeptide intermediates
US4597901A (en) * 1984-12-14 1986-07-01 Smithkline Beckman Corporation β-indolylalanyl or β-indolylglycinyl vasopressin antagonists
US4719199A (en) * 1984-12-14 1988-01-12 Smithkline Beckman Corporation Diuretic compositions and methods of producing diuresis
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
FR2663934B1 (fr) * 1990-06-27 1994-06-03 Adir Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent.
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
GB9502540D0 (en) * 1995-02-09 1995-03-29 Zeneca Ltd Compounds
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
EP0981363B1 (en) 1997-05-13 2003-07-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP0980253B1 (en) * 1997-05-13 2004-03-31 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x
EP0981364B1 (en) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
AU1602100A (en) 1998-11-25 2000-06-13 Warner-Lambert Company Improved gamma amino butyric acid analogs
HUP0400245A3 (en) 2001-06-08 2012-09-28 Ipsen Pharma Sas Somatostatin-dopamine chimeric analogs and pharmaceutical compositions containing them
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2523197C (en) 2003-04-22 2016-05-24 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Peptide vectors
AR044852A1 (es) * 2003-06-24 2005-10-05 Novartis Ag Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
JP5728380B2 (ja) 2008-06-12 2015-06-03 シンタクシン リミテッドＳｙｎｔａｘｉｎ Ｌｉｍｉｔｅｄ 神経内分泌疾患の抑制
BRPI0915142A8 (pt) 2008-06-12 2018-01-02 Syntaxin Ltd Polipeptídeos, ácido nucleico e usos dos mesmos
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
DK3007704T3 (da) 2013-06-13 2021-03-29 Antisense Therapeutics Ltd Kombinationsterapi til akromegali

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3875207A (en) * 1967-01-25 1975-04-01 Ciba Geigy Corp Process for the temporary protection of amino groups in peptide syntheses
US3944590A (en) * 1967-01-25 1976-03-16 Ciba-Geigy Corporation Process for the temporary protection of amino groups in peptide syntheses
US3725380A (en) * 1969-04-05 1973-04-03 Hoechst Ag Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole
CH577464A5 (ko) * 1972-09-22 1976-07-15 Ciba Geigy Ag
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden

Also Published As

Publication number Publication date
KR840000927B1 (ko) 1984-06-29
IL60474A0 (en) 1980-09-16
NO802009L (no) 1981-01-05
IL60474A (en) 1983-10-31
IE49995B1 (en) 1986-01-22
AU6007380A (en) 1981-01-15
EP0023192A1 (de) 1981-01-28
PT71490A (de) 1980-08-01
HU188081B (en) 1986-03-28
IE801371L (en) 1981-01-04
DD152543A5 (de) 1981-12-02
NO152092B (no) 1985-04-22
ES493029A0 (es) 1981-06-16
NO152092C (no) 1985-07-31
ES8105698A1 (es) 1981-06-16
NZ194227A (en) 1983-05-31
DE3067252D1 (en) 1984-05-03
GR69319B (ko) 1982-05-14
AU539499B2 (en) 1984-10-04
DK287680A (da) 1981-01-05
US4328214A (en) 1982-05-04
FI802079A (fi) 1981-01-05
EP0023192B1 (de) 1984-03-28
CA1148146A (en) 1983-06-14

Similar Documents

Publication Publication Date Title
KR830003401A (ko) 신규 사이클로 펩타이드, 그 약학적 제제 및 그들의 제법
KR830007567A (ko) 1, 2, 3, 4-테트라하이드로이소퀴놀린-3-카복실산의 치환아실 유도체의 제조방법.
ES8204412A1 (es) Procedimiento para la obtencion de un octapeptido ciclico
KR830004216A (ko) 아실펩타이드의 제조방법
ES473677A1 (es) Procedimiento para la obtencion de ciclopeptidos
KR830001872A (ko) 펩타이드 및 그의 제조방법
FI824419L (fi) Cykliska oktapeptider och farmaceutiska preparat daerav, samt foerfarande foer deras framstaellningderas anvaendning
CA2060034A1 (en) Tumour growth-inhibiting somatostatin analogues, pharmaceutical compositions containing them and process for preparing same
KR840009069A (ko) 향정신성 펩티드류의 제조 방법
DK149091C (da) Analogifremgangsmaade til fremstilling af peptider indeholdende 2-7 aminosyrerester, desaminodipeptider eller amider deraf med ubiquitin-lignende aktivitet eller farmaceutisk acceptable syreadditionssalte deraf
ES460618A1 (es) Procedimiento para la preparacion de derivados de peptido
KR880005149A (ko) 개선된 용해성을 갖는 고나도리베린의 동족체, 이의 제조방법, 이를 함유하는 제제 및 이의 용도
ES281304A1 (es) Un procedimiento para la preparación de nuevos polipéptidos hipotensores
ES403973A1 (es) Un procedimiento para la preparacion de monapeptidos.
GB1067935A (en) Improvements in or relating to nonapeptide derivatives
HUP0004177A2 (hu) 4,5-Diaril-oxazol származékok, a vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
GB1309464A (en) Biologically active polypeptides
SE7909653L (sv) Tyrosylerade proinsulin c-peptidderivat
KR890001977A (ko) 피로글루타미드 유도체
ES418929A1 (es) Procedimiento para la preparacion de polipeptidos.
KR900017610A (ko) 고나돌리베린 유도체를 함유하는 종양억제용 약제조성물의 제조방법
GB1391688A (en) Cyclic decapeptides
KR840001123A (ko) 불소화된 디아미노알켄 유도체의 제조방법
JPS5251093A (en) Mthod of preparing peptides
KR840005078A (ko) A-21978c 사이클릭 펩타이드 유도체의 제조방법