ES460618A1 - Procedimiento para la preparacion de derivados de peptido - Google Patents
Procedimiento para la preparacion de derivados de peptidoInfo
- Publication number
- ES460618A1 ES460618A1 ES460618A ES460618A ES460618A1 ES 460618 A1 ES460618 A1 ES 460618A1 ES 460618 A ES460618 A ES 460618A ES 460618 A ES460618 A ES 460618A ES 460618 A1 ES460618 A1 ES 460618A1
- Authority
- ES
- Spain
- Prior art keywords
- lys
- carbons
- radicals
- group
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
- C07K14/6955—Corticotropin [ACTH] with at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Procedimiento para la preparación de derivados de péptidos de fórmula: A-L-B-D-Lis-L-Fen-Gli-(L o D) Lis-L-Pro-L-Val-Gli-L-Lis-L-Lis-X o un derivado funcional de los mismos, donde A es una prolongación de cadena N terminal elegida del grupo que consta de (1) hidrógeno y (2) los radicales N-Acilo derivados de (a) ácidos alcohilcarboxílicos que tienen de uno a aproximadamente seis átomos de carbono, (b) ácidos aralcohilcarboxílicos que tienen de siete a aproximadamente diez carbonos, © aminoácidos, (d) péptidos, (e) los derivados de N-alcohilcarbonilo o N-aralcohilcarbonilo de dichos aminoácidos y (f) los derivados de N-alcohilcarabonilo o N-aralcohilcarbonilo de dichos péptidos , B es un resto de aminoácido elegido del grupo que consta de Fen, Trp, Tir y -NH-CHR1-CO-, donde R1 es hidrógeno o alcohilo de uno a aproximadamente seis átomos de carbono y X es un miembro elegido del grupo que consta de hidroxilo , radicales hidroxilo esterificado, radical amino no sustituido y radicales amino sustituidos, caracterizado porque un compuesto de fórmula A-L-B-D-Lis(Q)-L-Fen-Gli(L o D)Lis(Q)-L-Pro-L-Val-Gli-L-Lis(Q)-L-Lis(Q)-X en la que (Q) representa un grupo protector de amino y A, B y X tienen los significados definidos anteriormente, con la condición de que los restos de aminoácido Lis y Gluen la definición de A y X estén provistos de un grupo protector y los restos de aminoácido de N y/o C terminales estén provistos opcionalmente con un grupo protector es desprotegido por medio de una reducción o hidrólisis a una temperatura comprendida entre -10ºC y 50ºC
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7607683A NL7607683A (nl) | 1976-07-12 | 1976-07-12 | Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES460618A1 true ES460618A1 (es) | 1979-06-01 |
Family
ID=19826578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES460618A Expired ES460618A1 (es) | 1976-07-12 | 1977-07-11 | Procedimiento para la preparacion de derivados de peptido |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4110322A (es) |
| JP (1) | JPS5325562A (es) |
| AU (1) | AU511395B2 (es) |
| BE (1) | BE856695A (es) |
| CA (1) | CA1109060A (es) |
| CH (1) | CH633523A5 (es) |
| DE (1) | DE2731282A1 (es) |
| DK (1) | DK149113B (es) |
| ES (1) | ES460618A1 (es) |
| FI (1) | FI67365C (es) |
| FR (1) | FR2358383A1 (es) |
| GB (1) | GB1566836A (es) |
| HU (1) | HU179665B (es) |
| IE (1) | IE45738B1 (es) |
| LU (1) | LU77739A1 (es) |
| NL (1) | NL7607683A (es) |
| SE (1) | SE442121B (es) |
| ZA (1) | ZA773935B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT387393B (de) * | 1978-07-18 | 1989-01-10 | Kabi Ab | Verfahren zur herstellung von neuen tripeptidderivaten |
| US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| NL8101724A (nl) * | 1981-04-08 | 1982-11-01 | Akzo Nv | Peptiden met zenuw-regenererende eigenschappen. |
| US4500713A (en) * | 1982-09-23 | 1985-02-19 | Usv Pharmaceutical Corporation | Therapeutic dipeptides |
| IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| US5212154A (en) * | 1987-08-14 | 1993-05-18 | Akzo N.V. | Preparation for treating complications in diabetes |
| GB2217319A (en) * | 1988-04-19 | 1989-10-25 | Synpharm Ltd | Racemic and optically active fatty amino acids, their homo- abd hetero-oligomers and conjugates, the process of their production, their pharmaceutical composi |
| IE912091A1 (en) * | 1990-07-18 | 1992-01-29 | Akzo Nv | Use of a centrally acting atch analog in the manufacture of a¹medicament |
| US5968895A (en) * | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| EP2316431B1 (en) * | 2003-04-08 | 2015-09-30 | Novartis AG | Solid oral composition comprising a S1P receptor agonist and a sugar alcohol |
| CA3110297A1 (en) * | 2018-08-23 | 2020-02-27 | Zion Medical B.V | Pharmaceutical compositions comprising integration-promoting peptides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL175618C (nl) * | 1972-07-15 | 1984-12-03 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat met psychofarmacologische werking, dat een peptide of peptide-derivaat bevat, alsmede een werkwijze ter bereiding van dergelijke peptiden. |
-
1976
- 1976-07-12 NL NL7607683A patent/NL7607683A/xx not_active Application Discontinuation
-
1977
- 1977-06-27 US US05/810,277 patent/US4110322A/en not_active Expired - Lifetime
- 1977-06-29 IE IE1349/77A patent/IE45738B1/en unknown
- 1977-06-29 ZA ZA00773935A patent/ZA773935B/xx unknown
- 1977-07-01 GB GB27657/77A patent/GB1566836A/en not_active Expired
- 1977-07-05 AU AU26752/77A patent/AU511395B2/en not_active Expired
- 1977-07-11 CH CH852477A patent/CH633523A5/de not_active IP Right Cessation
- 1977-07-11 FI FI772155A patent/FI67365C/fi not_active IP Right Cessation
- 1977-07-11 JP JP8343577A patent/JPS5325562A/ja active Pending
- 1977-07-11 DK DK314277AA patent/DK149113B/da not_active Application Discontinuation
- 1977-07-11 LU LU77739A patent/LU77739A1/xx unknown
- 1977-07-11 DE DE19772731282 patent/DE2731282A1/de not_active Withdrawn
- 1977-07-11 BE BE179250A patent/BE856695A/xx not_active IP Right Cessation
- 1977-07-11 SE SE7708037A patent/SE442121B/xx unknown
- 1977-07-11 CA CA282,395A patent/CA1109060A/en not_active Expired
- 1977-07-11 ES ES460618A patent/ES460618A1/es not_active Expired
- 1977-07-12 HU HU77AO449A patent/HU179665B/hu unknown
- 1977-07-12 FR FR7721532A patent/FR2358383A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK314277A (da) | 1978-01-13 |
| FI67365C (fi) | 1985-03-11 |
| BE856695A (fr) | 1978-01-11 |
| SE442121B (sv) | 1985-12-02 |
| HU179665B (en) | 1982-11-29 |
| FR2358383B1 (es) | 1980-04-04 |
| JPS5325562A (en) | 1978-03-09 |
| FI67365B (fi) | 1984-11-30 |
| AU2675277A (en) | 1979-01-11 |
| US4110322A (en) | 1978-08-29 |
| IE45738L (en) | 1978-01-12 |
| IE45738B1 (en) | 1982-11-17 |
| ZA773935B (en) | 1978-05-30 |
| DE2731282A1 (de) | 1978-01-19 |
| LU77739A1 (es) | 1977-10-14 |
| DK149113B (da) | 1986-01-27 |
| AU511395B2 (en) | 1980-08-14 |
| NL7607683A (nl) | 1978-01-16 |
| SE7708037L (sv) | 1978-01-13 |
| CA1109060A (en) | 1981-09-15 |
| FI772155A (es) | 1978-01-13 |
| CH633523A5 (de) | 1982-12-15 |
| FR2358383A1 (fr) | 1978-02-10 |
| GB1566836A (en) | 1980-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971103 |