HUP9802556A1 - Eljárás és készítmény kötőszöveti kapcsolódások gyógyítására és helyreállítására - Google Patents
Eljárás és készítmény kötőszöveti kapcsolódások gyógyítására és helyreállításáraInfo
- Publication number
- HUP9802556A1 HUP9802556A1 HU9802556A HUP9802556A HUP9802556A1 HU P9802556 A1 HUP9802556 A1 HU P9802556A1 HU 9802556 A HU9802556 A HU 9802556A HU P9802556 A HUP9802556 A HU P9802556A HU P9802556 A1 HUP9802556 A1 HU P9802556A1
- Authority
- HU
- Hungary
- Prior art keywords
- connective tissue
- tube
- healing
- repair
- compositions
- Prior art date
Links
- 210000002808 connective tissue Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000035876 healing Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000008929 regeneration Effects 0.000 abstract 2
- 238000011069 regeneration method Methods 0.000 abstract 2
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány tárgya eljárás kötőszövet és csőnt, illetve ín és csőntközötti összeköttetés helyreállítására, azzal jellemzeve, hőgy afűnkciőnális összeköttetés regenerációt igénylő területére őlyangyógyászatilag alkalmazható készítményt helyeznek, amely megfelelőmennyiségű tisztítőtt csőntmőrfőgenetikűs prőteint (BMP) tartalmazahhőz, hőgy a kötőszövet-csőnt fűnkciőnális összeköttetésregenerációját létrehőzza. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46249795A | 1995-06-05 | 1995-06-05 | |
PCT/US1996/007282 WO1996039169A1 (en) | 1995-06-05 | 1996-05-21 | Methods and compositions for healing and repair of connective tissue attachment |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9802556A1 true HUP9802556A1 (hu) | 1999-03-29 |
HUP9802556A3 HUP9802556A3 (en) | 1999-04-28 |
HU222664B1 HU222664B1 (hu) | 2003-09-29 |
Family
ID=23836637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9802556A HU222664B1 (hu) | 1995-06-05 | 1996-05-21 | Csont morfogenetikus protein (BMP) alkalmazása csont és ín vagy szalag funkcionális összeköttetésének regenerálására |
Country Status (18)
Country | Link |
---|---|
US (1) | US6187742B1 (hu) |
EP (3) | EP1364656B1 (hu) |
JP (1) | JPH11507032A (hu) |
KR (1) | KR100440645B1 (hu) |
CN (1) | CN1133462C (hu) |
AT (1) | ATE245996T1 (hu) |
AU (1) | AU699918B2 (hu) |
CA (1) | CA2220555C (hu) |
DE (1) | DE69629294T2 (hu) |
DK (2) | DK0831884T3 (hu) |
ES (2) | ES2203701T3 (hu) |
FI (1) | FI116511B (hu) |
HK (1) | HK1017841A1 (hu) |
HU (1) | HU222664B1 (hu) |
OA (1) | OA10547A (hu) |
PT (1) | PT831884E (hu) |
TW (1) | TW449478B (hu) |
WO (1) | WO1996039169A1 (hu) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
EP0612348B1 (en) * | 1991-11-04 | 2003-04-23 | Genetics Institute, LLC | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
ES2255059T3 (es) * | 1993-12-07 | 2006-06-16 | Genetics Institute, Llc | Bmp-12, bmp-13 y composiciones suyas inductoras de tendon. |
US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
US6083522A (en) * | 1997-01-09 | 2000-07-04 | Neucoll, Inc. | Devices for tissue repair and methods for preparation and use thereof |
ATE239514T1 (de) † | 1997-02-07 | 2003-05-15 | Stryker Corp | Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung |
US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
CN1068793C (zh) * | 1997-04-17 | 2001-07-25 | 中国人民解放军第四军医大学全军创伤骨科研究所 | 骨生长刺激素注射剂及其制备方法 |
ATE220564T1 (de) | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren |
US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
EP2286847A1 (en) * | 1999-10-15 | 2011-02-23 | Genetics Institute, LLC | Formulations of hyaluronic acid for delivery of osteogenic proteins |
US6632246B1 (en) | 2000-03-14 | 2003-10-14 | Chondrosite, Llc | Cartilage repair plug |
US6626945B2 (en) | 2000-03-14 | 2003-09-30 | Chondrosite, Llc | Cartilage repair plug |
WO2001070288A2 (en) * | 2000-03-23 | 2001-09-27 | Genetics Institute, Inc. | Thermoreversible polymers for delivery and retention of osteoinductive proteins |
US6878166B2 (en) * | 2000-08-28 | 2005-04-12 | Ron Clark | Method and implant for securing ligament replacement into the knee |
US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
US20020114795A1 (en) * | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
ES2305246T3 (es) * | 2001-06-01 | 2008-11-01 | Wyeth | Composiciones para la administracion sistemica de secuencias que codifican proteinas oseas morfogeneticas. |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
DE60205937T3 (de) | 2001-11-19 | 2016-01-21 | Scil Technology Gmbh | Methode zur Herstellung einer homogen beschichtete Vorrichtung mit osteoinduktiven und osteokonduktiven Eigenschaft |
AU2003209071B2 (en) * | 2002-02-08 | 2008-08-14 | The University Of Erlangen-Nuremberg | Formulation comprising bioactive agents and method of using same |
CA2486113A1 (en) * | 2002-05-17 | 2003-12-04 | Wyeth | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
US7622562B2 (en) * | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
EP1539261B1 (en) * | 2002-09-10 | 2006-04-12 | Scil Technology GmbH | Metal implant coated under reduced oxygen concentration with osteoinductive protein |
EP2374471A1 (en) | 2003-09-12 | 2011-10-12 | Wyeth LLC | Injectable hardenable calcium phosphate pastes for delivery of osteogenic proteins |
US7896917B2 (en) * | 2003-10-15 | 2011-03-01 | Biomet Sports Medicine, Llc | Method and apparatus for graft fixation |
WO2005086706A2 (en) * | 2004-03-05 | 2005-09-22 | The Trustees Of Columbia University In The City Of New York | Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone |
US8002778B1 (en) | 2004-06-28 | 2011-08-23 | Biomet Sports Medicine, Llc | Crosspin and method for inserting the same during soft ligament repair |
WO2006081379A1 (en) * | 2005-01-26 | 2006-08-03 | Wyeth | Use of sfrps as markers of bmp activity |
MX2007011591A (es) * | 2005-03-30 | 2007-12-10 | Wyeth Corp | Metodo para estimular el crecimiento de cabello administrando bmps. |
US20060287675A1 (en) * | 2005-06-15 | 2006-12-21 | Prajapati Rita T | Method of intra-operative coating therapeutic agents onto sutures composite sutures and methods of use |
US20060287676A1 (en) * | 2005-06-15 | 2006-12-21 | Rita Prajapati | Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use |
US20060286289A1 (en) * | 2005-06-15 | 2006-12-21 | Rita Prajapati | Method of intraoperative coating therapeutic agents onto sutures |
US20100047309A1 (en) * | 2006-12-06 | 2010-02-25 | Lu Helen H | Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods |
AU2007234612B2 (en) * | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
US8753391B2 (en) | 2007-02-12 | 2014-06-17 | The Trustees Of Columbia University In The City Of New York | Fully synthetic implantable multi-phased scaffold |
US8147546B2 (en) * | 2007-03-13 | 2012-04-03 | Biomet Sports Medicine, Llc | Method and apparatus for graft fixation |
US8075562B2 (en) * | 2007-06-25 | 2011-12-13 | Wisconsin Alumni Research Foundation | Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
JP5323832B2 (ja) | 2007-08-07 | 2013-10-23 | アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー | 酸性水溶液中にgdf−5を含むタンパク質製剤 |
US7947649B2 (en) * | 2008-04-14 | 2011-05-24 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered GDF-5 formulations |
EP2598177B1 (en) | 2010-07-30 | 2015-06-17 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Drug delivery devices and growth factor formulations for accelerated wound healing |
EP2640429B1 (en) | 2010-11-15 | 2016-12-21 | Zimmer Orthobiologics, Inc. | Bone void fillers |
EP2537538A1 (en) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbable Wound Dressing |
WO2014169249A1 (en) | 2013-04-12 | 2014-10-16 | The Trustees Of Columbia University In The City Of New York | Methods for host cell homing and dental pulp regeneration |
JP2017525675A (ja) * | 2014-07-09 | 2017-09-07 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 回旋筋腱板異常の処置 |
EP3322481A4 (en) | 2015-07-16 | 2019-03-06 | Mayo Foundation for Medical Education and Research | TREATMENT OF ROTATOR COIL DRESSES |
CN110893250B (zh) * | 2019-10-11 | 2022-03-15 | 许和平 | 瘢痕/粘连阻挡膜及其制备方法和用途 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
IL83003A (en) * | 1986-07-01 | 1995-07-31 | Genetics Inst | Factors that soak bone formation |
US5108922A (en) | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
US5187076A (en) | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US5024841A (en) | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5256418A (en) | 1990-04-06 | 1993-10-26 | Organogenesis, Inc. | Collagen constructs |
ATE209251T1 (de) | 1990-05-16 | 2001-12-15 | Genetics Inst | Knochen- und knorpel-bildung hervorrufende proteine |
CA2071912C (en) * | 1990-11-30 | 2002-10-15 | Hanne Bentz | Use of a bone morphogenetic protein in synergistic combination with tgf-beta for bone repair |
US5206028A (en) | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
CA2111199C (en) | 1991-06-21 | 2008-08-05 | Eyal Ron | Pharmaceutical formulations of osteogenic proteins |
KR100255415B1 (ko) | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
US5171579A (en) | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
EP0612348B1 (en) | 1991-11-04 | 2003-04-23 | Genetics Institute, LLC | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
JP3193050B2 (ja) | 1992-02-12 | 2001-07-30 | ビオファルム ゲゼルシャフト ツア ビオテヒノロ ギッシェン エントヴィックルング フォン ファル マカ ミット ベシュレンクテル ハフツング | 新規の増殖/分化因子をコード化するdna配列 |
JPH08501779A (ja) * | 1992-09-15 | 1996-02-27 | クリエイティブ バイオモレキュルズ,インコーポレイテッド | モルフォゲン誘導歯周組織再生 |
EP1475440A3 (en) | 1993-01-12 | 2004-11-17 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-3 |
WO1994015966A1 (en) | 1993-01-12 | 1994-07-21 | Johns Hopkins University School Of Medicine | Growth differentiation factor-9 |
WO1994015949A1 (en) | 1993-01-12 | 1994-07-21 | Johns Hopkins University School Of Medicine | Growth differentiation factor-5 |
CA2157577C (en) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
CA2161807A1 (en) | 1993-05-12 | 1994-11-24 | Anthony J. Celeste | Bmp-10 compositions |
EP2272959A1 (en) | 1993-05-12 | 2011-01-12 | Genetics Institute, LLC | BMP-11 compositions |
FR2706749B1 (fr) | 1993-06-23 | 1995-08-25 | Oreal | Brosse pour appliquer un produit de maquillage, en particulier du mascara |
CA2165776A1 (en) | 1993-07-09 | 1995-01-19 | Se-Jin Lee | Growth differentiation factor-6 |
CA2165778A1 (en) | 1993-07-09 | 1995-01-19 | Se-Jin Lee | Growth differentiation factor-7 |
ES2255059T3 (es) * | 1993-12-07 | 2006-06-16 | Genetics Institute, Llc | Bmp-12, bmp-13 y composiciones suyas inductoras de tendon. |
US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
US5635372A (en) * | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
-
1996
- 1996-05-21 PT PT96916513T patent/PT831884E/pt unknown
- 1996-05-21 CA CA2220555A patent/CA2220555C/en not_active Expired - Lifetime
- 1996-05-21 AT AT96916513T patent/ATE245996T1/de active
- 1996-05-21 ES ES96916513T patent/ES2203701T3/es not_active Expired - Lifetime
- 1996-05-21 EP EP03015894.3A patent/EP1364656B1/en not_active Expired - Lifetime
- 1996-05-21 ES ES03015894.3T patent/ES2440441T3/es not_active Expired - Lifetime
- 1996-05-21 KR KR1019970708278A patent/KR100440645B1/ko not_active IP Right Cessation
- 1996-05-21 AU AU59234/96A patent/AU699918B2/en not_active Expired
- 1996-05-21 DK DK96916513T patent/DK0831884T3/da active
- 1996-05-21 DE DE69629294T patent/DE69629294T2/de not_active Revoked
- 1996-05-21 HU HU9802556A patent/HU222664B1/hu active IP Right Grant
- 1996-05-21 DK DK03015894.3T patent/DK1364656T3/da active
- 1996-05-21 CN CNB961944358A patent/CN1133462C/zh not_active Expired - Lifetime
- 1996-05-21 EP EP96916513A patent/EP0831884B1/en not_active Revoked
- 1996-05-21 WO PCT/US1996/007282 patent/WO1996039169A1/en active IP Right Grant
- 1996-05-21 EP EP10179024A patent/EP2289536A1/en not_active Withdrawn
- 1996-05-21 JP JP9500616A patent/JPH11507032A/ja not_active Withdrawn
- 1996-05-24 TW TW085106195A patent/TW449478B/zh not_active IP Right Cessation
-
1997
- 1997-12-02 FI FI974395A patent/FI116511B/fi not_active IP Right Cessation
- 1997-12-05 OA OA70152A patent/OA10547A/en unknown
-
1998
- 1998-10-20 HK HK98111338A patent/HK1017841A1/xx not_active IP Right Cessation
-
1999
- 1999-03-23 US US09/274,575 patent/US6187742B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0831884A1 (en) | 1998-04-01 |
ES2440441T3 (es) | 2014-01-29 |
EP1364656B1 (en) | 2013-11-20 |
US6187742B1 (en) | 2001-02-13 |
EP0831884B1 (en) | 2003-07-30 |
FI116511B (fi) | 2005-12-15 |
EP1364656A3 (en) | 2003-12-10 |
CN1186438A (zh) | 1998-07-01 |
ES2203701T3 (es) | 2004-04-16 |
JPH11507032A (ja) | 1999-06-22 |
FI974395A (fi) | 1997-12-02 |
EP1364656A2 (en) | 2003-11-26 |
PT831884E (pt) | 2003-11-28 |
CA2220555A1 (en) | 1996-12-12 |
TW449478B (en) | 2001-08-11 |
EP2289536A1 (en) | 2011-03-02 |
HU222664B1 (hu) | 2003-09-29 |
HUP9802556A3 (en) | 1999-04-28 |
DE69629294T2 (de) | 2004-04-29 |
DE69629294D1 (de) | 2003-09-04 |
FI974395A0 (fi) | 1997-12-02 |
HK1017841A1 (en) | 1999-12-03 |
CN1133462C (zh) | 2004-01-07 |
AU699918B2 (en) | 1998-12-17 |
KR100440645B1 (ko) | 2004-09-18 |
AU5923496A (en) | 1996-12-24 |
OA10547A (en) | 2002-05-31 |
KR19990014932A (ko) | 1999-02-25 |
DK1364656T3 (da) | 2013-12-16 |
ATE245996T1 (de) | 2003-08-15 |
CA2220555C (en) | 2011-07-19 |
WO1996039169A1 (en) | 1996-12-12 |
DK0831884T3 (da) | 2003-11-03 |
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Date | Code | Title | Description |
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HFG4 | Patent granted, date of granting |
Effective date: 20030708 |