ATE510552T1 - Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors - Google Patents

Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors

Info

Publication number
ATE510552T1
ATE510552T1 AT97929783T AT97929783T ATE510552T1 AT E510552 T1 ATE510552 T1 AT E510552T1 AT 97929783 T AT97929783 T AT 97929783T AT 97929783 T AT97929783 T AT 97929783T AT E510552 T1 ATE510552 T1 AT E510552T1
Authority
AT
Austria
Prior art keywords
thyrotropine
receptor
human
producing secreted
short variants
Prior art date
Application number
AT97929783T
Other languages
English (en)
Inventor
Basil Rapoport
Sandra Mclachlan
Original Assignee
Basil Rapoport
Sandra Mclachlan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basil Rapoport, Sandra Mclachlan filed Critical Basil Rapoport
Application granted granted Critical
Publication of ATE510552T1 publication Critical patent/ATE510552T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
AT97929783T 1996-06-05 1997-06-05 Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors ATE510552T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1917196P 1996-06-05 1996-06-05
PCT/US1997/009624 WO1997046206A2 (en) 1996-06-05 1997-06-05 Human thyrotropin receptor compositions and use thereof

Publications (1)

Publication Number Publication Date
ATE510552T1 true ATE510552T1 (de) 2011-06-15

Family

ID=21791804

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97929783T ATE510552T1 (de) 1996-06-05 1997-06-05 Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors

Country Status (6)

Country Link
EP (1) EP0959896B1 (de)
JP (1) JP2000512280A (de)
AT (1) ATE510552T1 (de)
AU (1) AU3376297A (de)
CA (1) CA2258720A1 (de)
WO (1) WO1997046206A2 (de)

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AU779986B2 (en) 1999-06-29 2005-02-24 Mannkind Corporation Purification and stabilization of peptide and protein pharmaceutical agents
WO2002034042A2 (en) * 2000-10-26 2002-05-02 Deltagen, Inc. Knockout mice thyroid stimulating hormone receptor (tsh-r) gene
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
JP5465878B2 (ja) 2005-09-14 2014-04-09 マンカインド コーポレイション 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN104689432B (zh) 2008-06-13 2018-07-06 曼金德公司 干粉吸入器和用于药物输送的系统
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
EP2440184B1 (de) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazin-mikropartikel mit definierten spefiischen oberflächenbereichen
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
DK2694402T3 (en) 2011-04-01 2017-07-03 Mannkind Corp BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (de) 2013-03-15 2022-07-13 MannKind Corporation Mikrokristalline diketopiperazinzusammensetzungen, verfahren zur herstellung und deren verwendung
WO2014186402A1 (en) 2013-05-14 2014-11-20 Siemens Healthcare Diagnostics Inc. Stabilized liquid formulations containing receptors
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0557273A1 (de) * 1990-11-15 1993-09-01 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Rat-thyrotropinrezeptorgen und deren verwendung

Also Published As

Publication number Publication date
JP2000512280A (ja) 2000-09-19
WO1997046206A2 (en) 1997-12-11
CA2258720A1 (en) 1997-12-11
AU3376297A (en) 1998-01-05
EP0959896A4 (de) 2005-03-02
EP0959896A2 (de) 1999-12-01
EP0959896B1 (de) 2011-05-25

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