HUP9802156A2 - Szulfonamiddal szubsztituált krománok, alkalmazásuk gyógyszerként, valamint ilyen vegyületeket tartalmazó gyógyászati készítmények és ezek előállítása - Google Patents
Szulfonamiddal szubsztituált krománok, alkalmazásuk gyógyszerként, valamint ilyen vegyületeket tartalmazó gyógyászati készítmények és ezek előállításaInfo
- Publication number
- HUP9802156A2 HUP9802156A2 HU9802156A HUP9802156A HUP9802156A2 HU P9802156 A2 HUP9802156 A2 HU P9802156A2 HU 9802156 A HU9802156 A HU 9802156A HU P9802156 A HUP9802156 A HU P9802156A HU P9802156 A2 HUP9802156 A2 HU P9802156A2
- Authority
- HU
- Hungary
- Prior art keywords
- hydrogen atom
- group
- medicaments
- cxh2x
- sulfonamide
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 3
- 150000001843 chromanes Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 206010022714 Intestinal ulcer Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány az új (I) általános képletű vegyületekre - a képletben aszubsztituensek fontosabb jelentései a következők: R(1) és R(2) jelentése hidrogénatom, CF3, C2F5, CsF7, 1-6 szénatomosalkilcsoport vagy fenilcsoport, R(3) jelentése R(10)-CnH2n-NR(11)- vagy R(10)-CnH2n- csoport, aholR(10) jelentése hidrogénatom vagy metilcsoport; R(4) jelentése R(13)-CrH2r-Z-CqH2q- csoport, ahol q és r jelentése 0,1, 2, 3, 4, 5, 6, 7 vagy 8; Z jelentése -O-CxH2x-O-, -O-CxH2x-CO-O-vagy -CO-O-CXH2X-O- csoport, ahol x jelentése 2, 3 vagy 4; R(5), R(6), R(7) és R(8) jelentése hidrogénatom, F, CI, Br, I, 1-5szénatomos alkilcsoport, 3-8 szénatomos cikloalkilcsoport, -CN, -CF3,-C2F5, -C3F7, -N3, -NO2 vagy fenilcsoport; R(9) jelentése hidrogénatom, OR(10d) vagy OCOR(10d) csoport, aholR(10d) jelentése hidrogénatom vagy 1-3 szénatomos alkilcsoport; B jelentése hidrogénatom, vagy R(9) és B jelentése együtt egy kötés -, és e vegyületek fiziológiailag elviselhető sóira vonatkozik. Atalálmány szerinti vegyületek a gyomor vagy a bélrendszer fekélyeinek,hasmenéses megbetegedések és az aritmiák összes típusának agyógyítására vagy megelőzésére alkalmazhatók. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742509A DE19742509A1 (de) | 1997-09-26 | 1997-09-26 | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| HU9802156D0 HU9802156D0 (en) | 1998-11-30 |
| HUP9802156A2 true HUP9802156A2 (hu) | 2001-04-28 |
| HUP9802156A3 HUP9802156A3 (en) | 2001-05-28 |
| HU224029B1 HU224029B1 (hu) | 2005-05-30 |
Family
ID=7843709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9802156A HU224029B1 (hu) | 1997-09-26 | 1998-09-25 | Szulfonamiddal szubsztituált krománok, eljárás előállításukra, alkalmazásuk gyógyszerként, valamint ilyen vegyületeket tartalmazó gyógyászati készítmények |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5955607A (hu) |
| EP (1) | EP0905131B1 (hu) |
| JP (1) | JP4279920B2 (hu) |
| KR (1) | KR19990030119A (hu) |
| CN (1) | CN1212964A (hu) |
| AR (1) | AR013518A1 (hu) |
| AT (1) | ATE215942T1 (hu) |
| AU (1) | AU741810B2 (hu) |
| BR (1) | BR9803974A (hu) |
| CA (1) | CA2249074A1 (hu) |
| CZ (1) | CZ293681B6 (hu) |
| DE (2) | DE19742509A1 (hu) |
| DK (1) | DK0905131T3 (hu) |
| ES (1) | ES2175582T3 (hu) |
| HR (1) | HRP980527B1 (hu) |
| HU (1) | HU224029B1 (hu) |
| ID (1) | ID20968A (hu) |
| IL (1) | IL126279A (hu) |
| MY (1) | MY119575A (hu) |
| NO (1) | NO319563B1 (hu) |
| NZ (1) | NZ332029A (hu) |
| PL (1) | PL328855A1 (hu) |
| PT (1) | PT905131E (hu) |
| RU (1) | RU2208611C2 (hu) |
| SI (1) | SI0905131T1 (hu) |
| SK (1) | SK282955B6 (hu) |
| TR (1) | TR199801902A2 (hu) |
| TW (1) | TW517053B (hu) |
| ZA (1) | ZA988790B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19742508A1 (de) * | 1997-09-26 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| DE19748469A1 (de) * | 1997-11-03 | 1999-05-06 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Benzopyranderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| EP1109801A1 (en) * | 1998-09-04 | 2001-06-27 | The Procter & Gamble Company | Substituted dihydrobenzopyrans useful as antiarrhythmic agents |
| DE19858253A1 (de) | 1998-12-17 | 2000-06-21 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden |
| US8225458B1 (en) | 2001-07-13 | 2012-07-24 | Hoffberg Steven M | Intelligent door restraint |
| US7368582B2 (en) | 2003-10-17 | 2008-05-06 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3737195A1 (de) * | 1987-11-03 | 1989-05-18 | Bayer Ag | Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US5104890A (en) * | 1989-03-28 | 1992-04-14 | Fujisawa Pharmaceutical Company, Ltd. | Benzopyran derivatives and processes for preparation thereof |
| US5428031A (en) * | 1991-12-03 | 1995-06-27 | Merck & Co., Inc. | Methods of treating cardiac arrhythmia |
| SK283837B6 (sk) * | 1996-05-15 | 2004-03-02 | Hoechst Aktiengesellschaft | Chrómany, spôsob ich prípravy, liečivá, ktoré ich obsahujú, a ich použitie |
| DE19706675A1 (de) * | 1997-02-20 | 1998-08-27 | Hoechst Ag | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1997
- 1997-09-26 DE DE19742509A patent/DE19742509A1/de not_active Withdrawn
-
1998
- 1998-09-17 IL IL12627998A patent/IL126279A/en not_active IP Right Cessation
- 1998-09-19 AT AT98117809T patent/ATE215942T1/de not_active IP Right Cessation
- 1998-09-19 EP EP98117809A patent/EP0905131B1/de not_active Expired - Lifetime
- 1998-09-19 ES ES98117809T patent/ES2175582T3/es not_active Expired - Lifetime
- 1998-09-19 DK DK98117809T patent/DK0905131T3/da active
- 1998-09-19 PT PT98117809T patent/PT905131E/pt unknown
- 1998-09-19 SI SI9830203T patent/SI0905131T1/xx unknown
- 1998-09-19 DE DE59803704T patent/DE59803704D1/de not_active Expired - Lifetime
- 1998-09-22 CN CN98119538A patent/CN1212964A/zh active Pending
- 1998-09-24 RU RU98117613/04A patent/RU2208611C2/ru not_active IP Right Cessation
- 1998-09-24 MY MYPI98004390A patent/MY119575A/en unknown
- 1998-09-24 NZ NZ332029A patent/NZ332029A/xx unknown
- 1998-09-24 AR ARP980104776A patent/AR013518A1/es unknown
- 1998-09-24 TR TR1998/01902A patent/TR199801902A2/xx unknown
- 1998-09-24 ID IDP981280A patent/ID20968A/id unknown
- 1998-09-24 BR BR9803974-1A patent/BR9803974A/pt not_active Application Discontinuation
- 1998-09-24 SK SK1319-98A patent/SK282955B6/sk unknown
- 1998-09-24 CZ CZ19983069A patent/CZ293681B6/cs not_active IP Right Cessation
- 1998-09-25 JP JP27216798A patent/JP4279920B2/ja not_active Expired - Lifetime
- 1998-09-25 HR HR980527A patent/HRP980527B1/xx not_active IP Right Cessation
- 1998-09-25 AU AU87083/98A patent/AU741810B2/en not_active Ceased
- 1998-09-25 US US09/160,304 patent/US5955607A/en not_active Expired - Lifetime
- 1998-09-25 PL PL98328855A patent/PL328855A1/xx unknown
- 1998-09-25 CA CA002249074A patent/CA2249074A1/en not_active Abandoned
- 1998-09-25 ZA ZA988790A patent/ZA988790B/xx unknown
- 1998-09-25 NO NO19984475A patent/NO319563B1/no unknown
- 1998-09-25 KR KR1019980039835A patent/KR19990030119A/ko active IP Right Grant
- 1998-09-25 HU HU9802156A patent/HU224029B1/hu not_active IP Right Cessation
- 1998-10-22 TW TW087115866A patent/TW517053B/zh active
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