HUP9602196A2 - Sulfonyl- and sulfinyl-benzoyl-guanidine derivatives and pharmaceutical compositions thereof - Google Patents

Sulfonyl- and sulfinyl-benzoyl-guanidine derivatives and pharmaceutical compositions thereof

Info

Publication number
HUP9602196A2
HUP9602196A2 HU9602196A HUP9602196A HUP9602196A2 HU P9602196 A2 HUP9602196 A2 HU P9602196A2 HU 9602196 A HU9602196 A HU 9602196A HU P9602196 A HUP9602196 A HU P9602196A HU P9602196 A2 HUP9602196 A2 HU P9602196A2
Authority
HU
Hungary
Prior art keywords
sulfinyl
sulfonyl
benzoyl
pharmaceutical compositions
guanidine derivatives
Prior art date
Application number
HU9602196A
Other languages
English (en)
Inventor
Rolf Dr Gericke
Manfred Dr Baumgarth
Klaus-Otto Dr Minck
Norbert Dr Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7769293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9602196(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HU9602196D0 publication Critical patent/HU9602196D0/hu
Publication of HUP9602196A2 publication Critical patent/HUP9602196A2/hu
Publication of HUP9602196A3 publication Critical patent/HUP9602196A3/hu
Publication of HU226134B1 publication Critical patent/HU226134B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Leads Or Probes (AREA)
HU9602196A 1995-08-11 1996-08-09 Sulfonyl- and sulfinyl-benzoyl-guanidine derivatives and pharmaceutical compositions thereof HU226134B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19529612A DE19529612A1 (de) 1995-08-11 1995-08-11 Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Publications (4)

Publication Number Publication Date
HU9602196D0 HU9602196D0 (en) 1996-10-28
HUP9602196A2 true HUP9602196A2 (en) 1997-05-28
HUP9602196A3 HUP9602196A3 (en) 1998-07-28
HU226134B1 HU226134B1 (en) 2008-05-28

Family

ID=7769293

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9602196A HU226134B1 (en) 1995-08-11 1996-08-09 Sulfonyl- and sulfinyl-benzoyl-guanidine derivatives and pharmaceutical compositions thereof

Country Status (25)

Country Link
US (1) US5744641A (hu)
EP (1) EP0758644B1 (hu)
JP (1) JP3901766B2 (hu)
KR (1) KR100447111B1 (hu)
CN (1) CN1071743C (hu)
AR (1) AR004677A1 (hu)
AT (1) ATE252075T1 (hu)
AU (1) AU709800B2 (hu)
BR (1) BR9603377B1 (hu)
CA (1) CA2183050C (hu)
CZ (1) CZ292974B6 (hu)
DE (2) DE19529612A1 (hu)
DK (1) DK0758644T3 (hu)
ES (1) ES2206534T3 (hu)
HU (1) HU226134B1 (hu)
MX (1) MX9603300A (hu)
NO (1) NO306858B1 (hu)
PL (1) PL184320B1 (hu)
PT (1) PT758644E (hu)
RU (1) RU2159232C2 (hu)
SI (1) SI0758644T1 (hu)
SK (1) SK281661B6 (hu)
TW (1) TW432039B (hu)
UA (1) UA45965C2 (hu)
ZA (1) ZA966773B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19833118C2 (de) 1998-07-23 2000-07-27 Merck Patent Gmbh Verfahren zur Herstellung von orthoalkylierten Benzoesäurederivaten
DE19903275A1 (de) * 1999-01-28 2000-08-03 Merck Patent Gmbh Lyophilisate mit verbesserter Rekonstituierbarkeit
DE19951418A1 (de) * 1999-10-26 2001-05-03 Merck Patent Gmbh Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
DE10001879A1 (de) * 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10023405A1 (de) 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
KR100643561B1 (ko) * 2000-12-08 2006-11-10 엘지.필립스 엘시디 주식회사 액정표시장치용 어레이기판과 어레이기판의 제조방법
DE10305070A1 (de) * 2003-02-07 2004-08-26 Merck Patent Gmbh Verwendung von N-(4,5-Methansulfonyl-2-methyl-benzoyl)-guanidin
JP2006525247A (ja) 2003-05-06 2006-11-09 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング グアニジン塩を結晶化する方法
DE102004045825A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Lyophilisat enthaltend N-Diaminomethylen-2-methyl-4,5-di-(methylsulfonyl)-benzamid
HUE026025T2 (hu) * 2008-05-09 2016-05-30 Merck Patent Gmbh Rimeporidot tartalmazó gyógyászati készítmény béta-sejt diszfunkciójával kapcsolatos betegségek kezelésére
AU2009289846B2 (en) * 2008-09-02 2014-10-16 Sanofi-Aventis Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
FR2948028B1 (fr) 2009-07-17 2011-12-02 Merck Sante Sas Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine
CN108602767A (zh) * 2016-02-08 2018-09-28 默克专利股份有限公司 N-(4,5-双甲磺酰基-2-甲基苯甲酰基)胍盐酸盐和n-(4,5-双甲磺酰基-2-甲基苯甲酰基)胍盐的结晶变体
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DK0589336T3 (da) * 1992-09-22 1997-06-16 Hoechst Ag Benzylguanidiner, fremgangsmåde til deres fremstilling samt deres anvendelse som antiarytmetika
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
EP0758644A1 (de) 1997-02-19
SK103396A3 (en) 1997-03-05
EP0758644B1 (de) 2003-10-15
NO963340D0 (no) 1996-08-09
KR100447111B1 (ko) 2004-12-08
AU709800B2 (en) 1999-09-09
HUP9602196A3 (en) 1998-07-28
CN1071743C (zh) 2001-09-26
SI0758644T1 (en) 2004-04-30
DE19529612A1 (de) 1997-02-13
ZA966773B (en) 1997-02-19
CZ231296A3 (en) 1997-02-12
MX9603300A (es) 1997-03-29
DK0758644T3 (da) 2003-12-22
AU6191796A (en) 1997-02-13
ES2206534T3 (es) 2004-05-16
TW432039B (en) 2001-05-01
AR004677A1 (es) 1999-03-10
HU226134B1 (en) 2008-05-28
SK281661B6 (sk) 2001-06-11
CZ292974B6 (cs) 2004-01-14
JP3901766B2 (ja) 2007-04-04
HU9602196D0 (en) 1996-10-28
BR9603377B1 (pt) 2009-01-13
US5744641A (en) 1998-04-28
PT758644E (pt) 2004-02-27
JPH0952876A (ja) 1997-02-25
CN1148590A (zh) 1997-04-30
NO306858B1 (no) 2000-01-03
KR970010740A (ko) 1997-03-27
UA45965C2 (uk) 2002-05-15
NO963340L (no) 1997-02-12
ATE252075T1 (de) 2003-11-15
RU2159232C2 (ru) 2000-11-20
DE59610773D1 (de) 2003-11-20
PL315611A1 (en) 1997-02-17
PL184320B1 (pl) 2002-10-31
CA2183050A1 (en) 1997-02-12
BR9603377A (pt) 1998-05-12
CA2183050C (en) 2008-09-30

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees