HUP0402155A2 - Multimer fehérjék új immunogén mimetikumai széleskörű T-sejt-epitóp-inszertekkel - Google Patents

Multimer fehérjék új immunogén mimetikumai széleskörű T-sejt-epitóp-inszertekkel

Info

Publication number
HUP0402155A2
HUP0402155A2 HU0402155A HUP0402155A HUP0402155A2 HU P0402155 A2 HUP0402155 A2 HU P0402155A2 HU 0402155 A HU0402155 A HU 0402155A HU P0402155 A HUP0402155 A HU P0402155A HU P0402155 A2 HUP0402155 A2 HU P0402155A2
Authority
HU
Hungary
Prior art keywords
versions
protein
mimetics
novel immunogenic
similar
Prior art date
Application number
HU0402155A
Other languages
English (en)
Inventor
Steen Klysner
Finn Stausholm Nielsen
Tomas Bratt
Bjorn Voldborg
Soren Mouritsen
Original Assignee
Pharmexa A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmexa A/S filed Critical Pharmexa A/S
Publication of HUP0402155A2 publication Critical patent/HUP0402155A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5409—IL-5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgyát képezi polimer fehérje, például interleukin-5 (IL5) és tumornekrózis-faktor-alfa (TNFa) új, immunogén analógjai. Azimmunogén analógok háromdimenziós térszerkezetükben hasonlítanak akiindulási molekulákhoz. Egyes változatok a multimerek monomerutánzatai, ahol a peptidösszekötők a monomeregységek térbeliszervezésén keresztül biztosítják a korrekt térszerkezet kialakítását.A változatok egy része monomer TNFa-változat, amely - miközbenszerkezetileg igen hasonlóak a natív fehérjéhez - előnyösen képesekmultimerizálódni. A találmány tárgyát képezik továbbá eljárásokpolimerfehérje autológ gazdaszervezetben való csökkentőszabályozására, készítmények multimerfehérje elleni antitestektermelésének indukálására, DNS-fragmensek, vektorok és gazdasejtek. Atalálmány szerinti eljárások és készítmények alkalmazhatók a humángyógyászatban. Ó
HU0402155A 2001-11-16 2002-11-15 Multimer fehérjék új immunogén mimetikumai széleskörű T-sejt-epitóp-inszertekkel HUP0402155A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33157501P 2001-11-16 2001-11-16
DKPA200101702 2001-11-16
PCT/DK2002/000764 WO2003042244A2 (en) 2001-11-16 2002-11-15 Immunogenic mimetics of multimer proteins with promiscuous t cell epitope inserts

Publications (1)

Publication Number Publication Date
HUP0402155A2 true HUP0402155A2 (hu) 2005-01-28

Family

ID=26069094

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402155A HUP0402155A2 (hu) 2001-11-16 2002-11-15 Multimer fehérjék új immunogén mimetikumai széleskörű T-sejt-epitóp-inszertekkel

Country Status (12)

Country Link
US (1) US20040258660A1 (hu)
EP (1) EP1448598A2 (hu)
JP (1) JP2005518194A (hu)
KR (1) KR20050044857A (hu)
CN (1) CN1615316A (hu)
CA (1) CA2467052A1 (hu)
EA (1) EA007810B1 (hu)
HU (1) HUP0402155A2 (hu)
IL (1) IL161708A0 (hu)
NZ (1) NZ533587A (hu)
PL (1) PL370082A1 (hu)
WO (1) WO2003042244A2 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003208314A1 (en) * 2002-03-11 2003-09-22 Pharmexa A/S Novel application of vaccination against tnf-alpha
CA2505870A1 (en) * 2002-12-11 2004-06-24 Soren Mouritsen Targeting single epitopes
CA2524623A1 (en) * 2003-05-09 2004-11-18 Pharmexa A/S Immunogenic human tnf alpha analogues with reduced cytotoxicity and methods of their preparation
DE102004014983A1 (de) * 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
EP2192924B1 (en) 2007-08-20 2017-10-11 Protalix Ltd. Saccharide-containing protein conjugates and uses thereof
EP2604693B1 (en) * 2008-07-21 2016-02-24 Apogenix GmbH TNFSF single chain molecules
JP5661735B2 (ja) * 2009-04-01 2015-01-28 ユニバーシティ オブ マイアミ ワクチン組成物及びその使用方法
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
EP2542572B1 (en) * 2010-03-02 2015-05-06 Protalix Ltd. Multimeric forms of therapeutic proteins and uses thereof
PT3272861T (pt) 2011-01-20 2020-03-26 Protalix Ltd Construção de ácido nucleico para expressão de alfα-galactosidase em plantas e células de plantas
KR101759687B1 (ko) * 2013-01-25 2017-07-19 타이몬, 엘엘씨 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법
JP2017525370A (ja) * 2014-08-21 2017-09-07 ザ ジェネラル ホスピタル コーポレイション 腫瘍壊死因子スーパーファミリーおよびｔｎｆ様リガンドムテインならびに腫瘍壊死因子スーパーファミリーおよびｔｎｆ様リガンドムテインを調製および使用する方法
AU2017405996A1 (en) 2017-03-27 2019-10-10 The University Of Queensland Chimeric insect-specific flaviviruses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1054937A (en) * 1975-01-28 1979-05-22 Gursaran P. Talwar Antipregnancy vaccine
DK96493D0 (da) * 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
EP0659438A1 (en) * 1993-12-23 1995-06-28 Boehringer Mannheim Gmbh Conjugates consisting of peptidic T cell antigens and cell binding groups, and their use for therapy
JP2002504342A (ja) * 1998-02-19 2002-02-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 一価ｍｈｃ結合ドメイン融合タンパク質および接合体、多価ｍｈｃ結合ドメイン融合タンパク質および接合体、ならびに多量体ｍｈｃ結合ドメイン融合タンパク質および接合体、そしてそれらのための使用
SE524775C2 (sv) * 1999-01-07 2004-09-28 Creative Media Design At Integ Lagringskort
US6614751B1 (en) * 1999-03-18 2003-09-02 Hisashi Katao Disk cartridge, optical disk drive, optical library and optical storage system
JP2000285514A (ja) * 1999-03-31 2000-10-13 Orient Sokki Computer Kk 非真円形光ディスク
AU777952B2 (en) * 1999-04-23 2004-11-04 Pharmexa A/S Method for down-regulating IL5 activity
DE10013287A1 (de) * 2000-03-17 2001-09-20 Fuji Magnetics Gmbh Optical-Business-Card
CA2403432A1 (en) * 2000-03-22 2001-09-27 Corixa Corporation Immune mediators and related methods

Also Published As

Publication number Publication date
PL370082A1 (en) 2005-05-16
WO2003042244A2 (en) 2003-05-22
WO2003042244A3 (en) 2003-11-13
NZ533587A (en) 2005-11-25
US20040258660A1 (en) 2004-12-23
CA2467052A1 (en) 2003-05-22
CN1615316A (zh) 2005-05-11
KR20050044857A (ko) 2005-05-13
JP2005518194A (ja) 2005-06-23
EA200400688A1 (ru) 2005-06-30
IL161708A0 (en) 2004-09-27
EP1448598A2 (en) 2004-08-25
EA007810B1 (ru) 2007-02-27

Similar Documents

Publication Publication Date Title
HUP0402155A2 (hu) Multimer fehérjék új immunogén mimetikumai széleskörű T-sejt-epitóp-inszertekkel
RU2020113032A (ru) Новые пептиды и комбинации пептидов для применения в иммунотерапии рака легких, в том числе немелкоклеточного рака легких (нмрл) и других видов рака
DE69834671D1 (de) Immunantwort gegen HPV Antigene hervorgerufen von Zusammensetzungen die ein HPV Antigen und ein Stressprotein enthalten oder einem Expressionsvektor fähig zur Expression dieser Proteine
EA200100425A1 (ru) Новые способы терапевтической вакцинации
DK521584A (da) Antigener, modificerede antigener og antigent modificerede polypeptider, fremgangsmaade til fremstilling heraf og vacciner indeholdende disse
EP1847549A3 (en) Papillomavirus polyprotein constructs
CY1105685T1 (el) Συνδεομενα με ογκους αντιγονικα παραγωγα απο την οικογενεια mage, και ακολουθιες νουκλεϊκων οξεων που τα κωδικοποιουν, χρησιμοποιουμενα στην παρασκευη πρωτεϊνων συντηξης και συνθεσεων για εμβολιασμο
ATE162723T1 (de) Die induktion der antikörperantwort gegen eigene proteine mit hilfe fremder t-zellepitope
CY1105555T1 (el) Ανθρωπινα πολυπεπτιδια pellino
WO2002008277A3 (en) Nucleic acids, vectors, host cells, polypeptides, and uses thereof
MXPA05013526A (es) Secuencias de acido nucleico que codifican y composiciones que comprenden el peptido de senal de ige y/o il-15 y metodos para uso de los mismos.
Braciale Antigen processing for presentation by MHC class I molecules
DK1151102T3 (da) Glycosylerede leptinpræparater og relaterede fremgangsmåder
RU2004133761A (ru) Модифицированный фактор viii
ATE412428T1 (de) Antigen-raster enthaltend rankl zur behandlung von knochenerkrankungen
EA200300640A1 (ru) Фармацевтические композиции, усиливающие иммуногенность антигенов со слабой иммуногенностью
NO902251L (no) Fremstilling av gonoreiske p1-proteiner og vaksiner.
EP0369816A3 (en) Monoclonal antibodies specific for human polymorphic epithelial mucin
EP0236977A3 (en) Bovine virus diarrhea and hog cholera vaccines
WO2002070665A3 (en) Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
ZA200602107B (en) Piroplasmid vaccine
DK1578772T3 (da) Cytokiner og cytokinreceptorer med reduceret immunogenicitet
WO2003059386A3 (en) Prion protein carrier-conjugates
EP1570051A4 (en) HYBRID GENES AND COMPOSITIONS COMPRISING RRE AND CTE AND USES THEREOF
WO2002038769A3 (de) Für expression in eukaryonten optimierte hpv 16-l1 und hpv 16-l2 kodierende dna-sequenzen

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees