EA200400688A1 - Иммуногенные миметики мультимерных белков с нерегулярными вставками т-клеточных эпитопов - Google Patents

Иммуногенные миметики мультимерных белков с нерегулярными вставками т-клеточных эпитопов

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Publication number
EA200400688A1
EA200400688A1 EA200400688A EA200400688A EA200400688A1 EA 200400688 A1 EA200400688 A1 EA 200400688A1 EA 200400688 A EA200400688 A EA 200400688A EA 200400688 A EA200400688 A EA 200400688A EA 200400688 A1 EA200400688 A1 EA 200400688A1
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EA
Eurasian Patent Office
Prior art keywords
variants
immunogenic
proteins
tnf
monomeric
Prior art date
Application number
EA200400688A
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English (en)
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EA007810B1 (ru
Inventor
Стеен Клюснер
Финн Стаусхольм Нильсен
Томас Братт
Бьерн Вольбор
Серен Моуритсен
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Фармекса А/С
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Publication of EA200400688A1 publication Critical patent/EA200400688A1/ru
Publication of EA007810B1 publication Critical patent/EA007810B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5409IL-5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к новым иммуногенным вариантам мультимерных белков, таких как иммуногенные варианты интерлейкина 5 (IL5) и фактора некроза опухолей α (TNF, TNF-α). Данные варианты, помимо того, что они иммуногенны у аутологичного хозяина, также обладают большим сходством с природной 3D-структурой белков, от которых они происходят. Некоторые варианты являются мономерными имитациями мультимеров, где пептидные линкеры (инертные или содержащие Т-хелперный эпитоп) обеспечивают пространственную организацию мономерных единиц, которая способствует правильному фолдингу. Подмножество вариантов представляет собой мономерные варианты TNF-α, которые проявляют высокую способность объединяться в мультимер с высокой степенью структурного сходства с нативным белком. Также описаны способы лечения и продукции данных вариантов, а также фрагменты ДНК, векторы и клетки хозяина.Отчет о международном поиске был опубликован 2003.11.13.
EA200400688A 2001-11-16 2002-11-15 Иммуногенные миметики мультимерных белков с нерегулярными вставками т-клеточных эпитопов EA007810B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33157501P 2001-11-16 2001-11-16
DKPA200101702 2001-11-16
PCT/DK2002/000764 WO2003042244A2 (en) 2001-11-16 2002-11-15 Immunogenic mimetics of multimer proteins with promiscuous t cell epitope inserts

Publications (2)

Publication Number Publication Date
EA200400688A1 true EA200400688A1 (ru) 2005-06-30
EA007810B1 EA007810B1 (ru) 2007-02-27

Family

ID=26069094

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Application Number Title Priority Date Filing Date
EA200400688A EA007810B1 (ru) 2001-11-16 2002-11-15 Иммуногенные миметики мультимерных белков с нерегулярными вставками т-клеточных эпитопов

Country Status (12)

Country Link
US (1) US20040258660A1 (ru)
EP (1) EP1448598A2 (ru)
JP (1) JP2005518194A (ru)
KR (1) KR20050044857A (ru)
CN (1) CN1615316A (ru)
CA (1) CA2467052A1 (ru)
EA (1) EA007810B1 (ru)
HU (1) HUP0402155A2 (ru)
IL (1) IL161708A0 (ru)
NZ (1) NZ533587A (ru)
PL (1) PL370082A1 (ru)
WO (1) WO2003042244A2 (ru)

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WO2003075951A2 (en) * 2002-03-11 2003-09-18 Pharmexa A/S Novel application of vaccination against tnf-alpha
AU2003285280A1 (en) * 2002-12-11 2004-06-30 Pharmexa A/S Targeting single epitopes
MXPA05011965A (es) * 2003-05-09 2006-02-02 Pharmexa As Analogos inmunogenicos de tnf-alfa humano con citotoxicidad reducida y metodos para su preparacion.
DE102004014983A1 (de) * 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US8742079B2 (en) 2007-08-20 2014-06-03 Protalix Ltd. Saccharide-containing protein conjugates and uses thereof
US8450460B2 (en) * 2008-07-21 2013-05-28 Apogenix Gmbh Single-chain TNFSF fusion polypeptides
JP5661735B2 (ja) 2009-04-01 2015-01-28 ユニバーシティ オブ マイアミ ワクチン組成物及びその使用方法
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
US20120328589A1 (en) * 2010-03-02 2012-12-27 Ilya Ruderfer Glucocerebrosidase multimers and uses thereof
AU2011356137A1 (en) 2011-01-20 2013-08-15 Protalix Ltd. Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells
KR101759687B1 (ko) * 2013-01-25 2017-07-19 타이몬, 엘엘씨 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법
JP2017525370A (ja) * 2014-08-21 2017-09-07 ザ ジェネラル ホスピタル コーポレイション 腫瘍壊死因子スーパーファミリーおよびtnf様リガンドムテインならびに腫瘍壊死因子スーパーファミリーおよびtnf様リガンドムテインを調製および使用する方法
US11572390B2 (en) 2017-03-27 2023-02-07 The University Of Queensland Chimeric insect-specific flaviviruses

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CA1054937A (en) * 1975-01-28 1979-05-22 Gursaran P. Talwar Antipregnancy vaccine
DK96493D0 (da) * 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
EP0659438A1 (en) * 1993-12-23 1995-06-28 Boehringer Mannheim Gmbh Conjugates consisting of peptidic T cell antigens and cell binding groups, and their use for therapy
JP2002504342A (ja) * 1998-02-19 2002-02-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 一価mhc結合ドメイン融合タンパク質および接合体、多価mhc結合ドメイン融合タンパク質および接合体、ならびに多量体mhc結合ドメイン融合タンパク質および接合体、そしてそれらのための使用
SE524775C2 (sv) * 1999-01-07 2004-09-28 Creative Media Design At Integ Lagringskort
US6614751B1 (en) * 1999-03-18 2003-09-02 Hisashi Katao Disk cartridge, optical disk drive, optical library and optical storage system
JP2000285514A (ja) * 1999-03-31 2000-10-13 Orient Sokki Computer Kk 非真円形光ディスク
EP1173573A1 (en) * 1999-04-23 2002-01-23 Pharmexa A/S Method for down-regulating il5 activity
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Also Published As

Publication number Publication date
US20040258660A1 (en) 2004-12-23
IL161708A0 (en) 2004-09-27
PL370082A1 (en) 2005-05-16
CA2467052A1 (en) 2003-05-22
EP1448598A2 (en) 2004-08-25
NZ533587A (en) 2005-11-25
WO2003042244A3 (en) 2003-11-13
JP2005518194A (ja) 2005-06-23
CN1615316A (zh) 2005-05-11
HUP0402155A2 (hu) 2005-01-28
EA007810B1 (ru) 2007-02-27
KR20050044857A (ko) 2005-05-13
WO2003042244A2 (en) 2003-05-22

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