HUP0401428A2 - Method for preparing 4-amino-4-phenylpiperidines - Google Patents

Method for preparing 4-amino-4-phenylpiperidines

Info

Publication number
HUP0401428A2
HUP0401428A2 HU0401428A HUP0401428A HUP0401428A2 HU P0401428 A2 HUP0401428 A2 HU P0401428A2 HU 0401428 A HU0401428 A HU 0401428A HU P0401428 A HUP0401428 A HU P0401428A HU P0401428 A2 HUP0401428 A2 HU P0401428A2
Authority
HU
Hungary
Prior art keywords
formula
protecting group
amino
salts
converted
Prior art date
Application number
HU0401428A
Other languages
English (en)
Inventor
Alain Alcade
Gilles Anne-Archard
Daniel Capraro
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of HUP0401428A2 publication Critical patent/HUP0401428A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A találmány valamely (I) képletű 4-amino-4-fenilpiperidin, - ahol Rjelentése hidrogén vagy (C1-C3)alkil-csoport - előállítási eljárásáravonatkozik oly módon, hogy a (II) képletű 1-védett 4-piperidont - aholPr' jelentése eltávolítható N-védőcsoport - szekvenciálisan előszöregy alkáli-cianiddal, majd valamely (III) képletű ENHPr'' aminnal -ahol E jelentése R' -(C1-C3)alkilcsoport vagy egy N-védőcsoport, ésPr'' jelentése egy N-védőcsoport, és a védőcsoport/védőcsoportokugyanazon körülmények között távolítható/távolíthatók el mint Pr' -kezelnek; az így kapott (IV) képletű vegyületet fenil-magnézium-halogeniddel Grignard-reakciónak vetik alá; és eltávolítják az ígykapott (V) képletű vegyület két vagy három N-védőcsoportját és az (I)képletű vegyületet izolálják, vagy egyik sója formájában, amit szabadbázissá alakítanak, vagy szabad bázis formájában, amit egyik sójáváalakítanak. Ó
HU0401428A 2001-07-16 2002-07-15 Method for preparing 4-amino-4-phenylpiperidines HUP0401428A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109576A FR2827282B1 (fr) 2001-07-16 2001-07-16 Procede pour la preparation de 4-amino-4-phenylpiperidines
PCT/FR2002/002499 WO2003008382A1 (fr) 2001-07-16 2002-07-15 Procede pour la preparation de 4-amino-4-phenylpiperidines

Publications (1)

Publication Number Publication Date
HUP0401428A2 true HUP0401428A2 (en) 2004-12-28

Family

ID=8865644

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401428A HUP0401428A2 (en) 2001-07-16 2002-07-15 Method for preparing 4-amino-4-phenylpiperidines

Country Status (15)

Country Link
US (1) US7045630B2 (hu)
EP (1) EP1409458B1 (hu)
JP (1) JP4441260B2 (hu)
CN (1) CN1284770C (hu)
AT (1) ATE334964T1 (hu)
BR (1) BR0211146A (hu)
CA (1) CA2450365A1 (hu)
DE (1) DE60213604T2 (hu)
ES (1) ES2269783T3 (hu)
FR (1) FR2827282B1 (hu)
HR (1) HRP20040031A2 (hu)
HU (1) HUP0401428A2 (hu)
MX (1) MXPA04000512A (hu)
PL (1) PL368939A1 (hu)
WO (1) WO2003008382A1 (hu)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1052302A (hu) * 1963-04-22
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1

Also Published As

Publication number Publication date
FR2827282A1 (fr) 2003-01-17
US7045630B2 (en) 2006-05-16
JP4441260B2 (ja) 2010-03-31
BR0211146A (pt) 2004-06-29
MXPA04000512A (es) 2004-07-23
ATE334964T1 (de) 2006-08-15
FR2827282B1 (fr) 2004-08-13
CA2450365A1 (en) 2003-01-30
WO2003008382A1 (fr) 2003-01-30
DE60213604D1 (de) 2006-09-14
CN1284770C (zh) 2006-11-15
US20040171837A1 (en) 2004-09-02
CN1533377A (zh) 2004-09-29
EP1409458B1 (fr) 2006-08-02
DE60213604T2 (de) 2007-08-09
ES2269783T3 (es) 2007-04-01
EP1409458A1 (fr) 2004-04-21
PL368939A1 (en) 2005-04-04
JP2004538284A (ja) 2004-12-24
HRP20040031A2 (en) 2004-06-30

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished