HUP0400216A2 - Eljárás paroxetin HCI előállítására, amely korlátozza a rózsaszín vegyületek képződését - Google Patents
Eljárás paroxetin HCI előállítására, amely korlátozza a rózsaszín vegyületek képződésétInfo
- Publication number
- HUP0400216A2 HUP0400216A2 HU0400216A HUP0400216A HUP0400216A2 HU P0400216 A2 HUP0400216 A2 HU P0400216A2 HU 0400216 A HU0400216 A HU 0400216A HU P0400216 A HUP0400216 A HU P0400216A HU P0400216 A2 HUP0400216 A2 HU P0400216A2
- Authority
- HU
- Hungary
- Prior art keywords
- paroxetine
- recrystallization
- antioxidant
- hcl
- colored compounds
- Prior art date
Links
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title abstract 5
- 229960002296 paroxetine Drugs 0.000 title abstract 5
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000003963 antioxidant agent Substances 0.000 abstract 3
- 230000003078 antioxidant effect Effects 0.000 abstract 3
- 235000006708 antioxidants Nutrition 0.000 abstract 3
- 238000001953 recrystallisation Methods 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 2
- 229960005070 ascorbic acid Drugs 0.000 abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 abstract 2
- 239000011668 ascorbic acid Substances 0.000 abstract 2
- 235000019270 ammonium chloride Nutrition 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgya eljárás paroxetin HCl előállítására paroxetinbázisból, amely eljárás terméke lényegében mentes a rózsaszínűvegyületektől, vagy azon szennyezőtől, amely HPLC RRT kb. 1,5 értékkelazonosítható. A találmány kivitelezhető pufferben, a HCl/paroxetinmólarány kisebb mint 1 és a kristályosítást/átkristályosítástantioxidáns hatékony mennyiségének a jelenlétében hajtják végre. Apuffer létrehozása előnyösen ammónium-kloriddal történhet. Előnyösantioxidáns az aszkorbinsav. A találmány tárgya eljárás paroxetin HClátkristályosítására is, amely a fenti, vagy más módszerrel készült,antioxidáns - mint például aszkorbinsav - hatékony mennyiségének ajelenlétében. Az átkristályosítás előnyös oldószerrendszere aceton ésmetanol keveréke. A találmány szerinti eljárások jellemzőikombinálhatók. Ó
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29860301P | 2001-06-14 | 2001-06-14 | |
| US32699301P | 2001-10-05 | 2001-10-05 | |
| US34604802P | 2002-01-04 | 2002-01-04 | |
| PCT/US2002/019016 WO2002102382A1 (en) | 2001-06-14 | 2002-06-14 | A PROCESS FOR PREPARING PAROXETINE HCl WHICH LIMITS FORMATION OF PINK COLORED COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0400216A2 true HUP0400216A2 (hu) | 2004-07-28 |
Family
ID=27404578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400216A HUP0400216A2 (hu) | 2001-06-14 | 2002-06-14 | Eljárás paroxetin HCI előállítására, amely korlátozza a rózsaszín vegyületek képződését |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20030083501A1 (hu) |
| EP (1) | EP1406625A4 (hu) |
| JP (1) | JP2005501819A (hu) |
| KR (1) | KR20040064615A (hu) |
| CN (1) | CN1516585A (hu) |
| CA (1) | CA2447808A1 (hu) |
| CZ (1) | CZ20033574A3 (hu) |
| HR (1) | HRP20040015A2 (hu) |
| HU (1) | HUP0400216A2 (hu) |
| IL (1) | IL159280A0 (hu) |
| IS (1) | IS7074A (hu) |
| MX (1) | MXPA03011594A (hu) |
| NO (1) | NO20035547D0 (hu) |
| PL (1) | PL372305A1 (hu) |
| SK (1) | SK12004A3 (hu) |
| TR (1) | TR200302081T2 (hu) |
| WO (1) | WO2002102382A1 (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777554B2 (en) * | 2001-02-05 | 2004-08-17 | Teva Pharmaceutical Industries Ltd. | Preparation of N-methylparoxetine and related intermediate compounds |
| AU2003271055B2 (en) * | 2002-09-19 | 2009-03-12 | Sumitomo Chemical Company, Limited | Methods of crystal precipitation |
| DE10327517A1 (de) | 2003-06-17 | 2005-01-13 | Ht Troplast Ag | Ionenleitende thermoplastische Zusammensetzungen für elektrochrome Verglasungen |
| WO2006113485A2 (en) * | 2005-04-15 | 2006-10-26 | Board Of Trustees Of Michigan State University | Aminergic pharmaceutical compositions and methods |
| GB201108345D0 (en) * | 2011-05-18 | 2011-06-29 | Aesica Pharmaceuticals Ltd | Process |
| US9254281B2 (en) * | 2011-09-12 | 2016-02-09 | Wright State University | Composition and method for the treatment of neurodegeneration |
| CN112159398A (zh) * | 2020-10-12 | 2021-01-01 | 浙江华海药业股份有限公司 | 一种盐酸帕罗西汀的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0223403B1 (en) * | 1985-10-25 | 1993-08-04 | Beecham Group Plc | Piperidine derivative, its preparation, and its use as medicament |
| US5856493A (en) * | 1995-02-06 | 1999-01-05 | Smithkline Beecham Corporation | Process for making novel form of paroxeting hydrochloride anhydrate |
| CA2206592A1 (en) * | 1996-05-30 | 1997-11-30 | Shu-Zhong Wang | Method of producing amorphous paroxetine hydrochloride |
| EP1394160A1 (en) * | 1996-06-13 | 2004-03-03 | SUMIKA FINE CHEMICALS Co., Ltd. | Process for preparing crystalline paroxetin hydrochloride |
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| US5672612A (en) * | 1996-09-09 | 1997-09-30 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
| CA2187128A1 (en) * | 1996-10-04 | 1997-06-26 | K. S. Keshava Murthy | New and useful polymorph of anhydrous paroxetine hydrochloride |
| CA2193939C (en) * | 1996-12-24 | 2002-02-12 | K.S. Keshava Murthy | Useful form of anhydrous paroxetine hydrochloride |
| EP0994872B9 (en) * | 1997-06-10 | 2001-12-05 | Synthon B.V. | 4-phenylpiperidine compounds |
| GB9808896D0 (en) * | 1998-04-25 | 1998-06-24 | Smithkline Beecham Plc | Novel compound |
| GB9826180D0 (en) * | 1998-11-30 | 1999-01-20 | Smithkline Beecham Plc | Novel process |
| IL154422A0 (en) * | 2000-08-28 | 2003-09-17 | Synthon Bv | Paroxetine compositions and processes for making the same |
-
2002
- 2002-06-04 IL IL15928002A patent/IL159280A0/xx unknown
- 2002-06-14 PL PL02372305A patent/PL372305A1/xx not_active Application Discontinuation
- 2002-06-14 HU HU0400216A patent/HUP0400216A2/hu unknown
- 2002-06-14 WO PCT/US2002/019016 patent/WO2002102382A1/en not_active Application Discontinuation
- 2002-06-14 JP JP2003504969A patent/JP2005501819A/ja active Pending
- 2002-06-14 TR TR2003/02081T patent/TR200302081T2/xx unknown
- 2002-06-14 MX MXPA03011594A patent/MXPA03011594A/es unknown
- 2002-06-14 KR KR10-2003-7016187A patent/KR20040064615A/ko not_active Application Discontinuation
- 2002-06-14 CN CNA028118901A patent/CN1516585A/zh active Pending
- 2002-06-14 SK SK1-2004A patent/SK12004A3/sk not_active Application Discontinuation
- 2002-06-14 CA CA002447808A patent/CA2447808A1/en not_active Abandoned
- 2002-06-14 US US10/172,521 patent/US20030083501A1/en not_active Abandoned
- 2002-06-14 EP EP02752054A patent/EP1406625A4/en not_active Withdrawn
- 2002-06-14 CZ CZ20033574A patent/CZ20033574A3/cs unknown
-
2003
- 2003-12-12 NO NO20035547A patent/NO20035547D0/no unknown
- 2003-12-12 IS IS7074A patent/IS7074A/is unknown
-
2004
- 2004-01-09 HR HR20040015A patent/HRP20040015A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20033574A3 (cs) | 2004-09-15 |
| IS7074A (is) | 2003-12-12 |
| CN1516585A (zh) | 2004-07-28 |
| US20030083501A1 (en) | 2003-05-01 |
| PL372305A1 (en) | 2005-07-11 |
| TR200302081T2 (tr) | 2004-09-21 |
| SK12004A3 (en) | 2004-05-04 |
| HRP20040015A2 (en) | 2004-10-31 |
| KR20040064615A (ko) | 2004-07-19 |
| EP1406625A4 (en) | 2005-03-23 |
| JP2005501819A (ja) | 2005-01-20 |
| EP1406625A1 (en) | 2004-04-14 |
| WO2002102382A1 (en) | 2002-12-27 |
| IL159280A0 (en) | 2004-06-01 |
| CA2447808A1 (en) | 2002-12-27 |
| NO20035547D0 (no) | 2003-12-12 |
| MXPA03011594A (es) | 2005-09-08 |
| WO2002102382A9 (en) | 2003-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |