MXPA04000512A - Proceso para preparar 4-amino-4-fenilpiperidinas. - Google Patents

Proceso para preparar 4-amino-4-fenilpiperidinas.

Info

Publication number
MXPA04000512A
MXPA04000512A MXPA04000512A MXPA04000512A MXPA04000512A MX PA04000512 A MXPA04000512 A MX PA04000512A MX PA04000512 A MXPA04000512 A MX PA04000512A MX PA04000512 A MXPA04000512 A MX PA04000512A MX PA04000512 A MXPA04000512 A MX PA04000512A
Authority
MX
Mexico
Prior art keywords
group
amino
preparing
eliminated
protecting
Prior art date
Application number
MXPA04000512A
Other languages
English (en)
Inventor
Capraro Daniel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MXPA04000512A publication Critical patent/MXPA04000512A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La invencion se refiere a un metodo para preparar una 4-amino-4-feniIpiperidina (1), en donde: R es hidrogeno o un grupo alquilo (C1-C3), caracterizado porque consiste en tratar secuencialmente 4-piperidona (II) protegida, en donde: Pr?? representa un grupo N-protector capaz de ser eliminado, primero con una cianuro alcalino despues con una amina ENHPr?? (III), en donde: E representa un grupo R??= grupo alquilo C1-C3 o un grupo N-protector y Pr???? es un grupo N-protector, el/los grupo(s) capaces de ser eliminados en las mismas condiciones que Pr??, despues someter el compuesto resultante (IV) a una reaccion Grignard con un haluro de fenilmagnesio, eliminar dos o tres grupos protectores del compuesto resultante (V) y aislar el compuesto (I) ya sea en la forma de una base libre que es transformada en una de sus sales.
MXPA04000512A 2001-07-16 2002-07-15 Proceso para preparar 4-amino-4-fenilpiperidinas. MXPA04000512A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109576A FR2827282B1 (fr) 2001-07-16 2001-07-16 Procede pour la preparation de 4-amino-4-phenylpiperidines
PCT/FR2002/002499 WO2003008382A1 (fr) 2001-07-16 2002-07-15 Procede pour la preparation de 4-amino-4-phenylpiperidines

Publications (1)

Publication Number Publication Date
MXPA04000512A true MXPA04000512A (es) 2004-07-23

Family

ID=8865644

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000512A MXPA04000512A (es) 2001-07-16 2002-07-15 Proceso para preparar 4-amino-4-fenilpiperidinas.

Country Status (15)

Country Link
US (1) US7045630B2 (es)
EP (1) EP1409458B1 (es)
JP (1) JP4441260B2 (es)
CN (1) CN1284770C (es)
AT (1) ATE334964T1 (es)
BR (1) BR0211146A (es)
CA (1) CA2450365A1 (es)
DE (1) DE60213604T2 (es)
ES (1) ES2269783T3 (es)
FR (1) FR2827282B1 (es)
HR (1) HRP20040031A2 (es)
HU (1) HUP0401428A2 (es)
MX (1) MXPA04000512A (es)
PL (1) PL368939A1 (es)
WO (1) WO2003008382A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1052302A (es) * 1963-04-22
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1

Also Published As

Publication number Publication date
FR2827282A1 (fr) 2003-01-17
US7045630B2 (en) 2006-05-16
JP4441260B2 (ja) 2010-03-31
BR0211146A (pt) 2004-06-29
ATE334964T1 (de) 2006-08-15
FR2827282B1 (fr) 2004-08-13
CA2450365A1 (en) 2003-01-30
WO2003008382A1 (fr) 2003-01-30
DE60213604D1 (de) 2006-09-14
CN1284770C (zh) 2006-11-15
US20040171837A1 (en) 2004-09-02
CN1533377A (zh) 2004-09-29
EP1409458B1 (fr) 2006-08-02
DE60213604T2 (de) 2007-08-09
HUP0401428A2 (en) 2004-12-28
ES2269783T3 (es) 2007-04-01
EP1409458A1 (fr) 2004-04-21
PL368939A1 (en) 2005-04-04
JP2004538284A (ja) 2004-12-24
HRP20040031A2 (en) 2004-06-30

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