HUP0401920A2 - Eljárás (2-nitro-fenil)-acetonitril-származékok előállítására, valamint intermedierjeik - Google Patents
Eljárás (2-nitro-fenil)-acetonitril-származékok előállítására, valamint intermedierjeikInfo
- Publication number
- HUP0401920A2 HUP0401920A2 HU0401920A HUP0401920A HUP0401920A2 HU P0401920 A2 HUP0401920 A2 HU P0401920A2 HU 0401920 A HU0401920 A HU 0401920A HU P0401920 A HUP0401920 A HU P0401920A HU P0401920 A2 HUP0401920 A2 HU P0401920A2
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- compounds
- group
- viii
- vii
- Prior art date
Links
- YPRFCQAWSNWRLM-UHFFFAOYSA-N 2-(2-nitrophenyl)acetonitrile Chemical class [O-][N+](=O)C1=CC=CC=C1CC#N YPRFCQAWSNWRLM-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000005181 nitrobenzenes Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A jelen találmány tárgya eljárás a (IV) általános képletű vegyületekahol X jelentése alkoximetilcsoport vagy alkoxikarbonilcsoportelőállítására, mely az alábbi 3 lépésből áll; (1) az első lépésben a(I) képletű vegyületeket reagáltatják a (VI) képletű vegyületekkel(R1)(R2)N-CH(OR3)(ORa) (VI) vagy a (VII) képletű vegyületek(CH3)2N-CH(OCH3)2 (VII) és a (VIII) képletű vegyületek(R1)(R2)NH (VIII) keverékével, majd az így kapott (IX) képletűvegyületeket savas körülmények között hidrolizálják - ahol aképletekben R1 és R2 lehet azonos vagy különböző és mindegyikjelentése alkilcsoport, valamint egymással kötésben jelenthetnek 5vagy 6 tagú gyűrűt a nitrogénatommal együtt; R3 és R4 lehet azonosvagy különböző és mindegyik jelentése alkilcsoport, X jelentése azelőzőekben megadott - melynek során a (II) képletű vegyületekkeletkeznek, (2) a következő lépésben a (II) képletű vegyületekethidroxil-aminnal reagáltatják, így a (III) képletű vegyületeketkapják. (3) végül a kapott (III) képletű vegyületeket dehidratálják,így a (IV) képletű vegyületeket kapják. A találmány továbbá az (V)általános képletű nitrobenzol származékokra - ahol Y jelentése metil-vagy 2-dialkilamino-etenil-csoport, és X jelentése az előzőekbenmegadott - is vonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001299205 | 2001-09-28 | ||
| PCT/JP2002/010099 WO2003029189A1 (en) | 2001-09-28 | 2002-09-27 | Process for producing (2-nitrophenyl)acetonitrile derivative and intermediate therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401920A2 true HUP0401920A2 (hu) | 2005-01-28 |
| HUP0401920A3 HUP0401920A3 (en) | 2005-10-28 |
Family
ID=19119994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401920A HUP0401920A3 (en) | 2001-09-28 | 2002-09-27 | Process for producing (2-nitrophenyl)acetonitrile derivatives and intermediates thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040199002A1 (hu) |
| EP (1) | EP1431278A4 (hu) |
| KR (1) | KR20040039430A (hu) |
| CN (1) | CN1578760A (hu) |
| CA (1) | CA2463232A1 (hu) |
| CZ (1) | CZ2004423A3 (hu) |
| HU (1) | HUP0401920A3 (hu) |
| WO (1) | WO2003029189A1 (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106164041B (zh) * | 2014-04-17 | 2018-05-04 | 住友化学株式会社 | 硝基化合物的制造方法 |
| US9975844B2 (en) | 2014-04-17 | 2018-05-22 | Sumitomo Chemical Company, Limited | Method for producing nitro compound |
| CN107163043A (zh) * | 2017-06-16 | 2017-09-15 | 上海毕得医药科技有限公司 | 一种吡唑并[1,5‑a]吡啶‑3‑羧酸酯衍生物的合成方法 |
| CN107628925A (zh) * | 2017-08-30 | 2018-01-26 | 中国石油化工股份有限公司 | 一种2‑苯基卤化甲基苯及其衍生物的制备方法 |
| CN109810020B (zh) * | 2019-02-28 | 2022-03-04 | 南京工业大学 | 一种氰基甲酰胺类化合物的合成方法 |
| CN110981825A (zh) * | 2019-12-19 | 2020-04-10 | 安徽省化工研究院 | 2-硝基苯甲酮类化合物、其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5913489B2 (ja) * | 1975-05-23 | 1984-03-30 | 泰治 榊田 | α−アルキル−α−フエニル酢酸の製造法 |
| DE2909871A1 (de) * | 1979-03-09 | 1980-09-18 | Schering Ag | Verfahren zur herstellung von nitrilen |
| EP0523067A1 (en) * | 1990-04-02 | 1993-01-20 | E.I. Du Pont De Nemours And Company | Crop-selective herbicidal sulfonamides |
| JPH05213902A (ja) * | 1992-02-07 | 1993-08-24 | Kumiai Chem Ind Co Ltd | ピリミジン誘導体及び除草剤 |
| MX9301088A (es) * | 1992-05-13 | 1993-11-01 | Syntex Inc | Derivados de indol, azaindol, y tetrahidro-1h-pirrol 2,3-c piridin-7-ona substituidos. |
| DE4302156A1 (de) * | 1993-01-27 | 1994-07-28 | Bayer Ag | Verfahren zur Herstellung von Aminomethylenverbindungen |
| JPH11100562A (ja) * | 1997-09-26 | 1999-04-13 | Sumitomo Bakelite Co Ltd | 多層プリント配線板用層間絶縁接着剤及び銅箔 |
| JP3561178B2 (ja) * | 1999-06-02 | 2004-09-02 | 花王株式会社 | ニトリルの製造方法 |
-
2002
- 2002-09-27 CZ CZ2004423A patent/CZ2004423A3/cs unknown
- 2002-09-27 CA CA002463232A patent/CA2463232A1/en not_active Abandoned
- 2002-09-27 CN CNA028217365A patent/CN1578760A/zh active Pending
- 2002-09-27 US US10/490,656 patent/US20040199002A1/en not_active Abandoned
- 2002-09-27 HU HU0401920A patent/HUP0401920A3/hu unknown
- 2002-09-27 KR KR10-2004-7004487A patent/KR20040039430A/ko not_active IP Right Cessation
- 2002-09-27 WO PCT/JP2002/010099 patent/WO2003029189A1/ja not_active Application Discontinuation
- 2002-09-27 EP EP02772940A patent/EP1431278A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1431278A1 (en) | 2004-06-23 |
| CZ2004423A3 (cs) | 2004-08-18 |
| CN1578760A (zh) | 2005-02-09 |
| EP1431278A4 (en) | 2006-01-25 |
| US20040199002A1 (en) | 2004-10-07 |
| KR20040039430A (ko) | 2004-05-10 |
| HUP0401920A3 (en) | 2005-10-28 |
| WO2003029189A1 (en) | 2003-04-10 |
| CA2463232A1 (en) | 2003-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |