HUP0400270A2 - Nagytisztaságú, meghatározott szemcseméretű butoconazol-nitrát és eljárás előállítására - Google Patents

Nagytisztaságú, meghatározott szemcseméretű butoconazol-nitrát és eljárás előállítására

Info

Publication number
HUP0400270A2
HUP0400270A2 HU0400270A HUP0400270A HUP0400270A2 HU P0400270 A2 HUP0400270 A2 HU P0400270A2 HU 0400270 A HU0400270 A HU 0400270A HU P0400270 A HUP0400270 A HU P0400270A HU P0400270 A2 HUP0400270 A2 HU P0400270A2
Authority
HU
Hungary
Prior art keywords
nitrate
formula
reaction
compound
butoconazole
Prior art date
Application number
HU0400270A
Other languages
English (en)
Inventor
László Czibula
László Dobay
Papp Éva Werkné
Bagdy Judit Nagyné
Ferenc Sebők
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU0400270A priority Critical patent/HUP0400270A3/hu
Publication of HU0400270D0 publication Critical patent/HU0400270D0/hu
Priority to PCT/HU2005/000002 priority patent/WO2005070897A1/en
Priority to EA200601373A priority patent/EA009238B1/ru
Priority to US10/584,662 priority patent/US7625935B2/en
Priority to DE602005015417T priority patent/DE602005015417D1/de
Priority to UAA200609221A priority patent/UA87674C2/ru
Priority to EP05702171A priority patent/EP1709005B1/en
Priority to EP07023914A priority patent/EP1903035A3/en
Priority to JP2006550311A priority patent/JP4795973B2/ja
Publication of HUP0400270A2 publication Critical patent/HUP0400270A2/hu
Priority to NO20063805A priority patent/NO20063805L/no
Publication of HUP0400270A3 publication Critical patent/HUP0400270A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

A találmány célja nagytisztaságú (I) képletű butoconazol-nitrát(kémiai nevén: 1-[4-(4-klórfenil)-2-(2,6-diklórfeniltio)-n-butil]-imidazol-nitrát), amely legfeljebb 0,10 tömeg% kémiai szennyezésttartalmaz és az anyag szemcséinek legalább 95%-a 75 mm-nél, legalább99%-a pedig 250 mm-nél kisebb átmérőjű. A találmány célja továbbáeljárás a fenti vegyület előállítására 1-klór-4(4-klórfenil)-2-butanolból és imidazolból kiindulva, a kapott (IV) képletű vegyülettionilkloriddal végzett reakciója és a kapott (V) képletű vegyület2,6-diklór-tiofenollal végzett reakciója útján, olyan módon, hogy azeljárás első lépését vízzel nem elegyedő oldószer és alkáli-fémhidroxid vagy karbonát vizes oldatának elegyében, fázistranszferkatalizátor jelenlétében végzik, majd a második lépést 1,2-diklóretánoldószerben, dimetilformamid jelenlétében hajtják végre és a reaktánstionilkloridot 1-1,2 mólnyi mennyiségben alkalmazzák a (IV) képletűvegyületre vonatkoztatva, továbbá a harmadik lépésben végrehajtottreakció termékét nem izolálják, és az így nyert oldatban lévőbutoconazolt (VI) salétromsavval kezelve nitrát-só formában izolálják.A találmány további tárgya a fent jellemzett szemcseméretű vegyületelőállítása nyers butoconazol-nitrátból kiindulva, olyan módon, hogy akiindulási anyagot 1-1,5:1 térfogatarányú metanol és metil-izobutil-keton oldószerelegyben feloldják és az oldatot +5 - -15 °C-ra hűtöttmetil-izobutil-ketonhoz adagolják, majd a kapott terméket izolálják.Tárgya a találmánynak továbbá gyógyszerkészítmény, amely hatóanyagkéntnagytisztaságú, meghatározott szemcseméretű butoconazol-nitrátot,valamint önmagukban ismert segédanyagokat tartalmaz.
HU0400270A 2004-01-27 2004-01-27 High purity butoconazole nitrate having a predetermined particle size and process for the production of the same HUP0400270A3 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
HU0400270A HUP0400270A3 (en) 2004-01-27 2004-01-27 High purity butoconazole nitrate having a predetermined particle size and process for the production of the same
JP2006550311A JP4795973B2 (ja) 2004-01-27 2005-01-25 特定の粒径を備えた高純度硝酸ブトコナゾール及びその製造方法
DE602005015417T DE602005015417D1 (de) 2004-01-27 2005-01-25 Hochreines butoconazolnitrat mit spezifischer teilchengrösse und verfahren zu dessen herstellung
EA200601373A EA009238B1 (ru) 2004-01-27 2005-01-25 Нитрат бутоконазола высокой степени чистоты с частицами заданного размера и способ его получения
US10/584,662 US7625935B2 (en) 2004-01-27 2005-01-25 High purity butoconazole nitrate with specified particle size and a process for the preparation thereof
PCT/HU2005/000002 WO2005070897A1 (en) 2004-01-27 2005-01-25 High purity butoconazole nitrate with specified particle size and a process for preparation thereof
UAA200609221A UA87674C2 (ru) 2004-01-27 2005-01-25 Способ получения нитрата бутоконазола
EP05702171A EP1709005B1 (en) 2004-01-27 2005-01-25 High purity butoconazole nitrate with specified particle size and a process for preparation thereof
EP07023914A EP1903035A3 (en) 2004-01-27 2005-01-25 High purity butoconazole nitrate with specified particle size and a process for preparation of thereof
NO20063805A NO20063805L (no) 2004-01-27 2006-08-25 Hoyrent butokonazolnitrat med spesifisert partikkelstorrelse og en fremgangsmate for fremstilling derav

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0400270A HUP0400270A3 (en) 2004-01-27 2004-01-27 High purity butoconazole nitrate having a predetermined particle size and process for the production of the same

Publications (3)

Publication Number Publication Date
HU0400270D0 HU0400270D0 (en) 2004-04-28
HUP0400270A2 true HUP0400270A2 (hu) 2005-12-28
HUP0400270A3 HUP0400270A3 (en) 2007-09-28

Family

ID=89981937

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400270A HUP0400270A3 (en) 2004-01-27 2004-01-27 High purity butoconazole nitrate having a predetermined particle size and process for the production of the same

Country Status (9)

Country Link
US (1) US7625935B2 (hu)
EP (2) EP1903035A3 (hu)
JP (1) JP4795973B2 (hu)
DE (1) DE602005015417D1 (hu)
EA (1) EA009238B1 (hu)
HU (1) HUP0400270A3 (hu)
NO (1) NO20063805L (hu)
UA (1) UA87674C2 (hu)
WO (1) WO2005070897A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102649796A (zh) * 2011-02-24 2012-08-29 四川滇虹医药开发有限公司 一种硝酸布康唑中间体的制备方法
CN105198814B (zh) * 2015-10-09 2018-03-20 株洲千金药业股份有限公司 一种工业化生产硝酸布康唑中间体的方法
CN105218456B (zh) * 2015-10-09 2018-07-03 株洲千金药业股份有限公司 一种工业化生产硝酸布康唑的方法
CN105218455B (zh) * 2015-10-09 2018-07-03 株洲千金药业股份有限公司 一种工业化连续生产硝酸布康唑的方法
CN105198816B (zh) * 2015-10-09 2018-05-01 株洲千金药业股份有限公司 一种工业化生产硝酸布康唑的方法
CN105175341B (zh) * 2015-10-09 2017-12-26 株洲千金药业股份有限公司 一种工业化合成硝酸布康唑中间体的方法
CN105175338B (zh) * 2015-10-09 2018-03-23 株洲千金药业股份有限公司 一种工业化生产硝酸布康唑中间体的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1567431A (en) * 1977-01-10 1980-05-14 Syntex Inc 1-(2-(halophenylthio)-4-(p-chloro- or-flrorophenyl)-n-butyl) imidazoles

Also Published As

Publication number Publication date
NO20063805L (no) 2006-08-25
JP4795973B2 (ja) 2011-10-19
EA009238B1 (ru) 2007-12-28
EP1903035A3 (en) 2009-01-07
US20080221190A1 (en) 2008-09-11
WO2005070897A1 (en) 2005-08-04
JP2007519699A (ja) 2007-07-19
DE602005015417D1 (de) 2009-08-27
UA87674C2 (ru) 2009-08-10
EP1903035A2 (en) 2008-03-26
EP1709005B1 (en) 2009-07-15
US7625935B2 (en) 2009-12-01
HU0400270D0 (en) 2004-04-28
HUP0400270A3 (en) 2007-09-28
EP1709005A1 (en) 2006-10-11
EA200601373A1 (ru) 2006-12-29

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished