JP4795973B2 - 特定の粒径を備えた高純度硝酸ブトコナゾール及びその製造方法 - Google Patents
特定の粒径を備えた高純度硝酸ブトコナゾール及びその製造方法 Download PDFInfo
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- JP4795973B2 JP4795973B2 JP2006550311A JP2006550311A JP4795973B2 JP 4795973 B2 JP4795973 B2 JP 4795973B2 JP 2006550311 A JP2006550311 A JP 2006550311A JP 2006550311 A JP2006550311 A JP 2006550311A JP 4795973 B2 JP4795973 B2 JP 4795973B2
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- chlorophenyl
- imidazole
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- 229910002651 NO3 Inorganic materials 0.000 title claims description 16
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title claims description 16
- 239000002245 particle Substances 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 24
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 24
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims description 24
- YAHZVMVZBIMHGM-UHFFFAOYSA-N 4-(4-chlorophenyl)-1-imidazol-1-ylbutan-2-ol Chemical compound C1=CN=CN1CC(O)CCC1=CC=C(Cl)C=C1 YAHZVMVZBIMHGM-UHFFFAOYSA-N 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 20
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 16
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 14
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 13
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- SWLMUYACZKCSHZ-UHFFFAOYSA-N butoconazole Chemical compound C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 SWLMUYACZKCSHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- DIPBOUCHGFINAT-UHFFFAOYSA-N 1-(1,4-dichlorocyclohexa-2,4-dien-1-yl)butan-2-ol Chemical compound CCC(O)CC1(Cl)CC=C(Cl)C=C1 DIPBOUCHGFINAT-UHFFFAOYSA-N 0.000 claims description 5
- PJMMKIMXEKRAAT-UHFFFAOYSA-N 1-[2-chloro-4-(4-chlorophenyl)butyl]imidazole Chemical compound C1=CN=CN1CC(Cl)CCC1=CC=C(Cl)C=C1 PJMMKIMXEKRAAT-UHFFFAOYSA-N 0.000 claims description 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 5
- ZHPWRQIPPNZNML-UHFFFAOYSA-N butoconazole nitrate Chemical compound O[N+]([O-])=O.C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 ZHPWRQIPPNZNML-UHFFFAOYSA-N 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 229910017604 nitric acid Inorganic materials 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 239000007858 starting material Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 4
- JBISHCXLCGVPGW-UHFFFAOYSA-N 2,6-dichlorobenzenethiol Chemical compound SC1=C(Cl)C=CC=C1Cl JBISHCXLCGVPGW-UHFFFAOYSA-N 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 4
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 4
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 3
- 239000003444 phase transfer catalyst Substances 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 2
- 150000002823 nitrates Chemical class 0.000 claims 1
- JBJWASZNUJCEKT-UHFFFAOYSA-M sodium;hydroxide;hydrate Chemical group O.[OH-].[Na+] JBJWASZNUJCEKT-UHFFFAOYSA-M 0.000 claims 1
- 239000000047 product Substances 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 150000002118 epoxides Chemical class 0.000 description 4
- 239000012044 organic layer Substances 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- 230000035484 reaction time Effects 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- 150000003934 aromatic aldehydes Chemical class 0.000 description 3
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 239000002360 explosive Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 150000002460 imidazoles Chemical class 0.000 description 3
- 239000012312 sodium hydride Substances 0.000 description 3
- 229910000104 sodium hydride Inorganic materials 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- HTZCNXWZYVXIMZ-UHFFFAOYSA-M benzyl(triethyl)azanium;chloride Chemical compound [Cl-].CC[N+](CC)(CC)CC1=CC=CC=C1 HTZCNXWZYVXIMZ-UHFFFAOYSA-M 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- -1 olefin compound Chemical class 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011345 viscous material Substances 0.000 description 2
- QGRKONUHHGBHRB-UHFFFAOYSA-N 2,3-dichlorobenzenethiol Chemical compound SC1=CC=CC(Cl)=C1Cl QGRKONUHHGBHRB-UHFFFAOYSA-N 0.000 description 1
- SLLDUURXGMDOCY-UHFFFAOYSA-N 2-butyl-1h-imidazole Chemical compound CCCCC1=NC=CN1 SLLDUURXGMDOCY-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WZELXJBMMZFDDU-UHFFFAOYSA-N Imidazol-2-one Chemical class O=C1N=CC=N1 WZELXJBMMZFDDU-UHFFFAOYSA-N 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960002120 butoconazole nitrate Drugs 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000007040 multi-step synthesis reaction Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000005029 sieve analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- BPLKQGGAXWRFOE-UHFFFAOYSA-M trimethylsulfoxonium iodide Chemical compound [I-].C[S+](C)(C)=O BPLKQGGAXWRFOE-UHFFFAOYSA-M 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
a)1−クロロ−4−クロロフェニル−2−ブタノールを式(III)のイミダゾールと反応させ式(IV)の化合物を産生し;
b)ステップa)にて得られた式(IV)の化合物を塩化チオニルと反応させ式(V)の化合物を産生し;そして、
c)ステップb)にて得られた式(V)の化合物を2,6−ジクロロチオフェノールと反応させるステップからなり、
ステップa)はアルカリ金属水酸化物又は炭酸塩の水溶液と水非混和性溶媒との混合物中にて相間移動触媒の存在下で実施され;
ステップb)は1,2−ジクロロエタン溶媒中にてジメチルホルムアミドの存在下で遂行され、一方、1−1.2モルの塩化チオニル試薬は式(IV)の化合物の量に基づいて使用され;そして、
ステップc)は生成物(VI)の分離なしで実施され;そして、
ステップc)にて得られたような溶液の状態であるブトコナゾール(VI)に対して、硝酸が添加され、生成物が硝酸塩として分離される。
200mlのトルエン中56.7g(0.26モル)の1−クロロ−4−クロロフェニル−2−ブタノール(J.of Medicinal Chemistry,1978.Vol.21.No.8.p.842)の溶液へ、100mlの水に溶解された36.2g(0.9モル)の水酸化ナトリウムと、6.4g(0.028モル)の塩化ベンジルトリエチルアンモニウムと、35.2g(0.51モル)のイミダゾール(III)を添加する。反応混合物を93−95℃にて1時間加熱し、次に温度を約60℃まで下げ、相に分離し、有機層へ水(100ml)を添加する。混合物を初め22−25℃にて1時間、次に0−5℃にて2時間撹拌する。結晶を濾過により分離し、0−5℃の水(2×35ml)で洗浄し、74gの湿った(1−[4−(4−クロロフェニル)−2−ヒドロキシ−n−ブチル]−イミダゾール)を産生し、これを真空にて最高50℃にて乾燥させ、61.6g(95%)の生成物を生じさせた。エチルアセテートからの再結晶は104−106℃にて融解する52.4g(85%)の乾燥生成物を生じさせる。
25g(0.1モル)の1−[4−(4−クロロフェニル)−2−ヒドロキシ−n−ブチル]−イミダゾール(IV)を1,2−ジクロロエタン(125ml)中に懸濁し、この懸濁物へジメチルホルムアミド(1ml)及び塩化チオニル(13.6g;0.11モル)を30−32℃にて添加し、そして、反応混合物を35−38℃にて1.5時間撹拌し続ける。塩素処理が完了した後、均質溶液を15−18℃まで冷却し、過剰な塩化チオニルを水(10ml)で分解し、次に再び水(80ml)を溶液に添加する。20−22℃にて0.5時間撹拌した後、相に分離し、有機層を水(30ml)で抽出する。水溶性溶液へメチルイソブチルケトン(250ml)を添加し混合物のpHを水(70ml)に溶解した15g(0.14モル)の炭酸ナトリウムで8.5−9へ調整する。混合物を22−25℃にて0.5時間撹拌し、相を分離し、有機層から一部分50ml蒸留して水を除去し、残りの溶液に26.8g(0.15ml)の2,6−ジクロロ−チオフェノール及び40g(0.29モル)の乾燥した炭酸カリウムを添加する。懸濁物を105−108℃にて窒素下で3−4時間撹拌する。反応が完了した後、無機塩類を濾過にて22−25℃にて除去し、濾過液を洗浄し活性炭で浄化し、約8−9mlの65%硝酸を添加することにより透明溶液のpHを3−3.5に調整する。溶液を1時間同じ温度で撹拌し、次に温度を8−12℃へ低下させる。得られた結晶を濾過し洗浄して48gの湿った硝酸1−[4−(4−クロロフェニル)−2−(2,6−ジクロロフェニルチオ)−n−ブチル]−イミダゾールを生じさせ、これは42.6g(90%)の乾燥生成物に相当する。
実施例2に記載のように得られた48gの湿った硝酸1−[4−(4−クロロフェニル)−2−(2,6ジクロロフェニルチオ)−n−ブチル]−イミダゾールをメタノール(120ml)及びメチルイソブチルケトン(96ml)の混合物中に65−70℃にて溶解し、この溶液を96mlのメチルイソブチルケトンに糸状に添加し−5℃に冷却する。形成された結晶懸濁物を撹拌しながら1時間0−10℃に保持し、次に濾過し0−5℃のメチルイソブチルケトン(2×15ml)で洗浄し、真空で50℃にてその重量が一定になるまで乾燥する。
不純物の総量:0.05%(HPLCで測定)
粒子寸法:<75μm97.4%;<250μm100%
装置の型式:スペクトラシステム/TSP(製造:サーモセパレーションプロダクツ、USA)
カラム:LiChrospher RP−18,250×4.0mm I.D.,5μm
(メルク,ドイツ,Cat.No.:1.50983)
移動相:メタノール:緩衝液=8:2
緩衝液:1000mlの蒸留水に溶解した2.18gKH2PO4+4.18gK2HPO4・3H2O;
MeOH(HPLC勾配等級(Gradient grade),メルク,ドイツ,Cat.No.:1.06007.2500)
KH2PO4(p.a.,メルク,ドイツ,Cat.No.:1.04877.1000)
K2HPO4・3H2O(p.a.,メルク,ドイツ,Cat.No.:1.05099.1000)
流速:1.0ml/分
温度:40℃
検出:UV229nm
サンプリング用溶媒:溶離液
サンプル濃度:1.0mg/ml
注入量:10μl
分析の継続時間:40分
評価:相対面積比較法
おおよその反応時間:11.9分
粒子寸法は空気の噴出によって操作されるアルパイン篩を用いた篩分析によって測定された。
Claims (8)
- 式(I)
a)1−クロロ−4−クロロフェニル−2−ブタノールを式(III)
b)ステップa)にて得られた式(IV)(1−[4−(4−クロロフェニル)−2−ヒドロキシ−n−ブチル]−イミダゾール)の化合物を塩化チオニルと反応させ式(V)(1−[4−(4−クロロフェニル)−2−クロロ−n−ブチル]−イミダゾール)の化合物を産生し;そして、
c)ステップb)にて得られた式(V)(1−[4−(4−クロロフェニル)−2−クロロ−n−ブチル]−イミダゾール)の化合物を2,6−ジクロロチオフェノールと反応させるステップからなり;
ステップa)はアルカリ金属水酸化物又は炭酸塩の水溶液と水非混和性溶媒との混合物中にて相間移動触媒の存在下で実施され;
ステップb)は1,2−ジクロロエタン溶媒中にてジメチルホルムアミドの存在下で遂行され、一方、1−1.2モルの塩化チオニル試薬は式(IV)(1−[4−(4−クロロフェニル)−2−ヒドロキシ−n−ブチル]−イミダゾール)の化合物の量に基づいて使用され;そして、
ステップc)は生成物(VI)1−[4−(4−クロロフェニル)−2−(2,6−ジクロロフェニルチオ)−n−ブチル]−イミダゾールの分離なしで実施され;そして、
ステップc)にて得られたような溶液の状態であるブトコナゾール(VI)1−[4−(4−クロロフェニル)−2−(2,6−ジクロロフェニルチオ)−n−ブチル]−イミダゾールに対して、硝酸が添加され、生成物が硝酸塩として分離されることを特徴とする製造方法。 - 水不混和性溶媒が芳香族炭化水素であることを特徴とする請求項1記載の方法。
- 芳香族炭化水素がトルエンであることを特徴とする請求項2記載の方法。
- アルカリ金属水酸化物又は炭酸塩が水酸化ナトリウム又は炭酸ナトリウムであることを特徴とする請求項1記載の方法。
- ステップb)において塩化チオニルが1.1モルの量使用されることを特徴とする請求項1記載の方法。
- 式(I)
化学的不純物を最大0.1重量%しか含まない高純度硝酸ブトコナゾールであり、少なくとも95%の物質の粒子が直径75μm未満であり、一方、粒子の少なくとも99%が直径250μm未満であり、
請求項1記載の製造方法から得られた化学的不純物を最大0.1重量%しか含まない硝酸ブトコナゾールから出発し、出発原料がメタノール及びメチルイソブチルケトンの1−1.5:1比率(v/v)混合物中に溶解され、この溶液は次にメチルイソブチルケトンへ添加され、5℃及び−15℃の間の温度へ冷却され、得られた生成物を分離することを特徴とする製造方法。 - 冷却温度が−5℃及び−10℃の間であることを特徴とする請求項6記載の方法。
- 出発原料用溶媒中のメタノール/メチルイソブチルケトンの体積比が1.25:1であることを特徴とする請求項6記載の方法。
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HU0400270A HUP0400270A3 (en) | 2004-01-27 | 2004-01-27 | High purity butoconazole nitrate having a predetermined particle size and process for the production of the same |
PCT/HU2005/000002 WO2005070897A1 (en) | 2004-01-27 | 2005-01-25 | High purity butoconazole nitrate with specified particle size and a process for preparation thereof |
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