HUP0400195A3 - Imidazole derivatives for modulatig sodium channels, pharmaceutical compositions containing them and use of imidazole derivatives for producing pharmaceutical compositions having sodium channels modulating effect - Google Patents
Imidazole derivatives for modulatig sodium channels, pharmaceutical compositions containing them and use of imidazole derivatives for producing pharmaceutical compositions having sodium channels modulating effectInfo
- Publication number
- HUP0400195A3 HUP0400195A3 HU0400195A HUP0400195A HUP0400195A3 HU P0400195 A3 HUP0400195 A3 HU P0400195A3 HU 0400195 A HU0400195 A HU 0400195A HU P0400195 A HUP0400195 A HU P0400195A HU P0400195 A3 HUP0400195 A3 HU P0400195A3
- Authority
- HU
- Hungary
- Prior art keywords
- pharmaceutical compositions
- sodium channels
- imidazole derivatives
- modulatig
- modulating effect
- Prior art date
Links
- 108010052164 Sodium Channels Proteins 0.000 title 2
- 102000018674 Sodium Channels Human genes 0.000 title 2
- 150000002460 imidazoles Chemical class 0.000 title 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 2
- 239000008194 pharmaceutical composition Substances 0.000 title 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Networks Using Active Elements (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Molds, Cores, And Manufacturing Methods Thereof (AREA)
- Control Of Transmission Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0107820A FR2825926A1 (fr) | 2001-06-14 | 2001-06-14 | Derives d'imidazoles modulant les canaux sodiques |
| PCT/FR2002/002039 WO2002102375A2 (fr) | 2001-06-14 | 2002-06-14 | Derives d'imidazoles modulant les canaux sodiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0400195A2 HUP0400195A2 (hu) | 2004-07-28 |
| HUP0400195A3 true HUP0400195A3 (en) | 2004-10-28 |
Family
ID=8864329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400195A HUP0400195A3 (en) | 2001-06-14 | 2002-06-14 | Imidazole derivatives for modulatig sodium channels, pharmaceutical compositions containing them and use of imidazole derivatives for producing pharmaceutical compositions having sodium channels modulating effect |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7157483B2 (hu) |
| EP (1) | EP1401432B1 (hu) |
| JP (1) | JP2005500297A (hu) |
| KR (1) | KR20040030672A (hu) |
| CN (1) | CN1535148A (hu) |
| AT (1) | ATE304354T1 (hu) |
| BR (1) | BR0210285A (hu) |
| CA (1) | CA2449916A1 (hu) |
| CZ (1) | CZ297321B6 (hu) |
| DE (1) | DE60206171T2 (hu) |
| DK (1) | DK1401432T3 (hu) |
| ES (1) | ES2249595T3 (hu) |
| FR (1) | FR2825926A1 (hu) |
| HU (1) | HUP0400195A3 (hu) |
| IS (1) | IS2367B (hu) |
| MX (1) | MXPA03011508A (hu) |
| NO (1) | NO20035553D0 (hu) |
| NZ (1) | NZ529741A (hu) |
| PL (1) | PL366722A1 (hu) |
| RU (1) | RU2296565C2 (hu) |
| WO (1) | WO2002102375A2 (hu) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1594847A2 (en) * | 2003-02-12 | 2005-11-16 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
| ZA200507752B (en) * | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| WO2005051298A2 (en) * | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| US20090232879A1 (en) | 2005-05-26 | 2009-09-17 | Metabasis Therapeutics, Inc. | Thyromimetics for the Treatment of Fatty Liver Diseases |
| WO2007002931A2 (en) | 2005-06-29 | 2007-01-04 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| US9284274B2 (en) | 2005-12-07 | 2016-03-15 | Ramot At Tel-Aviv University Ltd. | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof |
| CA2630666A1 (en) * | 2005-12-07 | 2007-06-14 | Sepal Pharma Ltd. | Jasmonate derivatives, pharmaceutical compositions and methods of use thereof |
| EP2402321A3 (en) * | 2005-12-07 | 2012-02-29 | Ramot at Tel Aviv University, Ltd. | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof |
| WO2008083101A1 (en) | 2006-12-26 | 2008-07-10 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs for the treatment of cancer |
| US7883898B2 (en) * | 2007-05-07 | 2011-02-08 | General Electric Company | Method and apparatus for measuring pH of low alkalinity solutions |
| US8188080B2 (en) * | 2007-10-17 | 2012-05-29 | Sanford-Burnham Medical Research Institute | VHR protein tyrosine phosphatase inhibitors, compositions and methods of use |
| EP2105164B1 (en) | 2008-03-25 | 2011-01-12 | Affectis Pharmaceuticals AG | Novel P2X7R antagonists and their use |
| US8815892B2 (en) | 2008-03-25 | 2014-08-26 | Affectis Pharmaceuticals Ag | P2X7R antagonists and their use |
| MY158622A (en) * | 2008-10-06 | 2016-10-31 | Shikoku Chem | 2-benzyl-4-(2,4-dichlorophenyl)-5-methylimidazole compound |
| US9284252B2 (en) | 2009-06-09 | 2016-03-15 | Sepal Pharma Ltd. | Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders |
| JP5368244B2 (ja) * | 2009-10-14 | 2013-12-18 | 四国化成工業株式会社 | ２−（２，４−ジクロロベンジル）−４−アリール−５−メチルイミダゾール化合物 |
| JP5368263B2 (ja) * | 2009-11-04 | 2013-12-18 | 四国化成工業株式会社 | ４−（２，４−ジクロロフェニル）−５−メチルイミダゾール化合物 |
| JP5368271B2 (ja) * | 2009-11-20 | 2013-12-18 | 四国化成工業株式会社 | ４−（４−ビフェニリル）−２−（２，４−ジクロロベンジル）イミダゾールおよび表面処理液 |
| KR20190104524A (ko) | 2016-11-21 | 2019-09-10 | 바이킹 테라퓨틱스 인코포레이티드 | 당원축적질환의 치료 방법 |
| EP3634426A4 (en) | 2017-06-05 | 2021-04-07 | Viking Therapeutics, Inc. | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS |
| EA202091979A1 (ru) | 2018-03-22 | 2021-06-22 | Вайкинг Терапьютикс, Инк. | Кристаллические формы и способы получения кристаллических форм соединения |
| US12102646B2 (en) | 2018-12-05 | 2024-10-01 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| WO2024097171A1 (en) * | 2022-10-31 | 2024-05-10 | Genep Inc. | Imidazole compounds and their use as sodium channel inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1046248A (en) * | 1962-08-02 | 1966-10-19 | Benger Lab Ltd | Substituted imidazoles |
| US6003118A (en) * | 1997-12-16 | 1999-12-14 | Acer Laboratories Inc. | Method and apparatus for synchronizing clock distribution of a data processing system |
| TR200102790T2 (tr) * | 1999-03-26 | 2002-06-21 | Euro-Celtique S.A. | Aril İkameli Pirazoller, İmidazoller, Oksazoller, Tiazoller ve Piroller Ve Bunların Kullanımı. |
| AR024077A1 (es) * | 1999-05-25 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| TWI283577B (en) * | 1999-10-11 | 2007-07-11 | Sod Conseils Rech Applic | Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof |
| NZ519272A (en) * | 1999-12-16 | 2004-02-27 | Schering Corp | Substituted imidazole neuropeptide Y Y5 receptor antagonists |
-
2001
- 2001-06-14 FR FR0107820A patent/FR2825926A1/fr not_active Withdrawn
-
2002
- 2002-06-14 EP EP02745529A patent/EP1401432B1/fr not_active Expired - Lifetime
- 2002-06-14 JP JP2003504962A patent/JP2005500297A/ja active Pending
- 2002-06-14 HU HU0400195A patent/HUP0400195A3/hu unknown
- 2002-06-14 DK DK02745529T patent/DK1401432T3/da active
- 2002-06-14 ES ES02745529T patent/ES2249595T3/es not_active Expired - Lifetime
- 2002-06-14 AT AT02745529T patent/ATE304354T1/de not_active IP Right Cessation
- 2002-06-14 KR KR10-2003-7016257A patent/KR20040030672A/ko active IP Right Grant
- 2002-06-14 PL PL02366722A patent/PL366722A1/xx not_active Application Discontinuation
- 2002-06-14 MX MXPA03011508A patent/MXPA03011508A/es active IP Right Grant
- 2002-06-14 WO PCT/FR2002/002039 patent/WO2002102375A2/fr active IP Right Grant
- 2002-06-14 BR BR0210285-4A patent/BR0210285A/pt not_active IP Right Cessation
- 2002-06-14 RU RU2004100843/15A patent/RU2296565C2/ru not_active IP Right Cessation
- 2002-06-14 US US10/480,977 patent/US7157483B2/en not_active Expired - Fee Related
- 2002-06-14 CZ CZ20033550A patent/CZ297321B6/cs not_active IP Right Cessation
- 2002-06-14 CN CNA028111842A patent/CN1535148A/zh active Pending
- 2002-06-14 CA CA002449916A patent/CA2449916A1/fr not_active Abandoned
- 2002-06-14 DE DE60206171T patent/DE60206171T2/de not_active Expired - Fee Related
- 2002-06-14 NZ NZ529741A patent/NZ529741A/en unknown
-
2003
- 2003-12-08 IS IS7067A patent/IS2367B/is unknown
- 2003-12-12 NO NO20035553A patent/NO20035553D0/no not_active Application Discontinuation
-
2005
- 2005-11-17 US US11/281,864 patent/US7402602B2/en not_active Expired - Fee Related
-
2006
- 2006-11-27 US US11/604,522 patent/US20070099975A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60206171T2 (de) | 2006-06-22 |
| US20040198792A1 (en) | 2004-10-07 |
| MXPA03011508A (es) | 2004-03-18 |
| FR2825926A1 (fr) | 2002-12-20 |
| WO2002102375A3 (fr) | 2003-09-25 |
| BR0210285A (pt) | 2004-06-29 |
| ATE304354T1 (de) | 2005-09-15 |
| CZ297321B6 (cs) | 2006-11-15 |
| CZ20033550A3 (cs) | 2005-05-18 |
| DK1401432T3 (da) | 2006-02-06 |
| US20070099975A1 (en) | 2007-05-03 |
| CA2449916A1 (fr) | 2002-12-27 |
| US7157483B2 (en) | 2007-01-02 |
| RU2296565C2 (ru) | 2007-04-10 |
| CN1535148A (zh) | 2004-10-06 |
| US7402602B2 (en) | 2008-07-22 |
| HUP0400195A2 (hu) | 2004-07-28 |
| NZ529741A (en) | 2006-10-27 |
| IS2367B (is) | 2008-06-15 |
| US20060069146A1 (en) | 2006-03-30 |
| WO2002102375A2 (fr) | 2002-12-27 |
| ES2249595T3 (es) | 2006-04-01 |
| IS7067A (is) | 2003-12-08 |
| JP2005500297A (ja) | 2005-01-06 |
| DE60206171D1 (de) | 2005-10-20 |
| EP1401432B1 (fr) | 2005-09-14 |
| KR20040030672A (ko) | 2004-04-09 |
| NO20035553D0 (no) | 2003-12-12 |
| RU2004100843A (ru) | 2005-04-10 |
| EP1401432A2 (fr) | 2004-03-31 |
| PL366722A1 (en) | 2005-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |