HUP0400063A2 - Fluor-oxo-indolszármazékok mint KCNQ káliumcsatorna modulátorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Fluor-oxo-indolszármazékok mint KCNQ káliumcsatorna modulátorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0400063A2 HUP0400063A2 HU0400063A HUP0400063A HUP0400063A2 HU P0400063 A2 HUP0400063 A2 HU P0400063A2 HU 0400063 A HU0400063 A HU 0400063A HU P0400063 A HUP0400063 A HU P0400063A HU P0400063 A2 HUP0400063 A2 HU P0400063A2
- Authority
- HU
- Hungary
- Prior art keywords
- modulators
- pharmaceutical compositions
- compositions containing
- potassium channels
- kcnq potassium
- Prior art date
Links
- SCRXASNUPJPFGP-UHFFFAOYSA-N 1-fluoro-3h-indol-2-one Chemical class C1=CC=C2N(F)C(=O)CC2=C1 SCRXASNUPJPFGP-UHFFFAOYSA-N 0.000 title 1
- 102000012359 KCNQ Potassium Channels Human genes 0.000 title 1
- 108010022282 KCNQ Potassium Channels Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27011201P | 2001-02-20 | 2001-02-20 | |
| PCT/US2002/004304 WO2002066426A2 (en) | 2001-02-20 | 2002-02-14 | Fluoro oxindole derivatives as modulators of kcnq potassium channels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0400063A2 true HUP0400063A2 (hu) | 2004-04-28 |
Family
ID=23029954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400063A HUP0400063A2 (hu) | 2001-02-20 | 2002-02-14 | Fluor-oxo-indolszármazékok mint KCNQ káliumcsatorna modulátorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1363624A2 (hu) |
| JP (1) | JP2004531483A (hu) |
| CA (1) | CA2438805A1 (hu) |
| HU (1) | HUP0400063A2 (hu) |
| WO (1) | WO2002066426A2 (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6855829B2 (en) | 2001-02-20 | 2005-02-15 | Bristol-Myers Squibb Company | 3-fluoro-2-oxindole modulators of KCNQ potassium channels and use thereof in treating migraine and mechanistically related disease |
| EP1631546A1 (en) * | 2003-04-25 | 2006-03-08 | H. Lundbeck A/S | Sustituted indoline and indole derivatives |
| WO2005035498A1 (ja) * | 2003-10-08 | 2005-04-21 | Dainippon Sumitomo Pharma Co., Ltd. | 含窒素二環性化合物の摂食調節剤としての用途 |
| EP2319512A1 (en) * | 2005-01-11 | 2011-05-11 | NeuroSearch AS | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels. |
| EP2540295A1 (en) * | 2011-06-27 | 2013-01-02 | Centre national de la recherche scientifique | Compositions for the treatment of Fragile X syndrome |
| CN110240558B (zh) * | 2019-07-10 | 2022-05-27 | 上海华理生物医药股份有限公司 | 一种Flindokalner消旋体的新合成方法 |
| EP3912625A1 (en) | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| AU760250B2 (en) * | 1998-12-04 | 2003-05-08 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| DE60037321D1 (de) * | 1999-08-04 | 2008-01-17 | Icagen Inc | Benzanilide als öffner des kaliumkanals |
-
2002
- 2002-02-14 CA CA002438805A patent/CA2438805A1/en not_active Abandoned
- 2002-02-14 HU HU0400063A patent/HUP0400063A2/hu unknown
- 2002-02-14 JP JP2002565943A patent/JP2004531483A/ja not_active Withdrawn
- 2002-02-14 WO PCT/US2002/004304 patent/WO2002066426A2/en not_active Application Discontinuation
- 2002-02-14 EP EP02714888A patent/EP1363624A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002066426A2 (en) | 2002-08-29 |
| WO2002066426A3 (en) | 2002-11-21 |
| JP2004531483A (ja) | 2004-10-14 |
| EP1363624A2 (en) | 2003-11-26 |
| CA2438805A1 (en) | 2002-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |