DE602006018255D1 - Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit - Google Patents
Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeitInfo
- Publication number
- DE602006018255D1 DE602006018255D1 DE602006018255T DE602006018255T DE602006018255D1 DE 602006018255 D1 DE602006018255 D1 DE 602006018255D1 DE 602006018255 T DE602006018255 T DE 602006018255T DE 602006018255 T DE602006018255 T DE 602006018255T DE 602006018255 D1 DE602006018255 D1 DE 602006018255D1
- Authority
- DE
- Germany
- Prior art keywords
- channels
- modulators
- amino
- calcium
- activated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64253805P | 2005-01-11 | 2005-01-11 | |
DKPA200500049 | 2005-01-11 | ||
DKPA200500240 | 2005-02-16 | ||
US65351305P | 2005-02-17 | 2005-02-17 | |
PCT/EP2006/050108 WO2006074991A1 (en) | 2005-01-11 | 2006-01-10 | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006018255D1 true DE602006018255D1 (de) | 2010-12-30 |
Family
ID=36010294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006018255T Active DE602006018255D1 (de) | 2005-01-11 | 2006-01-10 | Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit |
Country Status (6)
Country | Link |
---|---|
US (3) | US7842817B2 (de) |
EP (2) | EP2319512A1 (de) |
JP (1) | JP2008526815A (de) |
AT (1) | ATE488235T1 (de) |
DE (1) | DE602006018255D1 (de) |
WO (1) | WO2006074991A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007042571A1 (en) * | 2005-10-14 | 2007-04-19 | Neurosearch A/S | Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
CA2637674A1 (en) * | 2006-01-19 | 2007-07-26 | Abbott Laboratories | 2-imino-benzimidazoles |
WO2008003752A1 (en) * | 2006-07-07 | 2008-01-10 | Neurosearch A/S | 2 -amino benzimidazole derivatives and their use as modulators of small - conductance calcium -act ivated potassium channels |
US8039632B2 (en) * | 2006-11-13 | 2011-10-18 | Neurosearch A/S | 2-aminio-pyridine derivatives and their use as potassium channel modulators |
JP2010509249A (ja) * | 2006-11-13 | 2010-03-25 | ノイロサーチ アクティーゼルスカブ | 新規な4−アミノ−ピリジン誘導体及びカリウムチャネルモジュレーターとしてのその使用 |
KR20110097932A (ko) | 2008-12-08 | 2011-08-31 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 치료용 화합물 |
JP2013532149A (ja) * | 2010-06-17 | 2013-08-15 | ノバルティス アーゲー | ピペリジニル置換1,3−ジヒドロ−ベンゾイミダゾール−2−イリデンアミン誘導体 |
CN102947274A (zh) * | 2010-06-17 | 2013-02-27 | 诺瓦提斯公司 | 联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物 |
EP2810773A1 (de) | 2013-06-05 | 2014-12-10 | Basell Poliolefine Italia S.r.l. | Buten-1-Copolymer Haftvermittler in Mehrschichtfolienstrukturen mit einer niedrigen Dichtungstemperatur und verbesserte Hot-Tack. |
CN105636950A (zh) | 2013-10-10 | 2016-06-01 | 巴斯夫欧洲公司 | 取代的n-(四唑-5-基)-和n-(三唑-5-基)芳基羧酰胺化合物及其作为除草剂的用途 |
WO2016077541A1 (en) * | 2014-11-12 | 2016-05-19 | The Trustees Of The University Of Pennsylvania | Novel anti-infective compounds and methods using same |
CN104744375B (zh) * | 2015-02-10 | 2017-09-19 | 南开大学 | 一种胍类ntr1小分子拮抗剂 |
JP7158464B2 (ja) * | 2017-08-14 | 2022-10-21 | アセシオン ファーマ エイピーエス | カリウムチャネル阻害剤としての置換ベンゾイミダゾール |
ES2885179T3 (es) * | 2017-08-23 | 2021-12-13 | Acesion Pharma Aps | Derivados de bencimidazol útiles como inhibidores del canal de potasio |
MX2020010155A (es) * | 2018-03-27 | 2021-03-25 | Univ Texas | Compuestos de ox2r. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3981886A (en) | 1975-01-20 | 1976-09-21 | E. R. Squibb & Sons, Inc. | Amino-benzimidazole derivatives |
US4004016A (en) | 1975-08-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Amino-benzimidazole derivatives |
JP2002519412A (ja) | 1998-07-02 | 2002-07-02 | ニューロサーチ、アクティーゼルスカブ | カリウムチャンネル遮断剤 |
US6194447B1 (en) * | 1998-07-02 | 2001-02-27 | Neurosearch A/S | Bis (benzimidazole) derivatives serving as potassium blocking agents |
MA26659A1 (fr) | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
EP1178977B1 (de) * | 1999-05-12 | 2005-06-01 | Neurosearch A/S | Ionenkanal modulierende mittel |
YU7203A (sh) | 2000-08-08 | 2006-01-16 | Sanofi-Aventis | Derivati benzimidazola, njihovo dobijanje i terapeutska primena |
WO2002066426A2 (en) * | 2001-02-20 | 2002-08-29 | Bristol-Myers Squibb Company | Fluoro oxindole derivatives as modulators of kcnq potassium channels |
DE10135050A1 (de) | 2001-07-09 | 2003-02-06 | Schering Ag | 1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
WO2003094861A2 (en) | 2002-05-13 | 2003-11-20 | Icagen, Inc. | Bis-benzimidazoles and related compounds as potassium channel modulators |
-
2006
- 2006-01-10 DE DE602006018255T patent/DE602006018255D1/de active Active
- 2006-01-10 JP JP2007549905A patent/JP2008526815A/ja not_active Abandoned
- 2006-01-10 EP EP10182012A patent/EP2319512A1/de not_active Withdrawn
- 2006-01-10 US US11/795,018 patent/US7842817B2/en not_active Expired - Fee Related
- 2006-01-10 AT AT06701206T patent/ATE488235T1/de not_active IP Right Cessation
- 2006-01-10 WO PCT/EP2006/050108 patent/WO2006074991A1/en active Application Filing
- 2006-01-10 EP EP06701206A patent/EP1838306B1/de not_active Not-in-force
-
2010
- 2010-07-08 US US12/832,343 patent/US20100280087A1/en not_active Abandoned
- 2010-10-21 US US12/909,362 patent/US20110034527A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2008526815A (ja) | 2008-07-24 |
US20100280087A1 (en) | 2010-11-04 |
EP1838306A1 (de) | 2007-10-03 |
WO2006074991A1 (en) | 2006-07-20 |
US20080200529A1 (en) | 2008-08-21 |
ATE488235T1 (de) | 2010-12-15 |
US7842817B2 (en) | 2010-11-30 |
US20110034527A1 (en) | 2011-02-10 |
EP1838306B1 (de) | 2010-11-17 |
EP2319512A1 (de) | 2011-05-11 |
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