DE602006018255D1 - Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit - Google Patents

Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit

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Publication number
DE602006018255D1
DE602006018255D1 DE602006018255T DE602006018255T DE602006018255D1 DE 602006018255 D1 DE602006018255 D1 DE 602006018255D1 DE 602006018255 T DE602006018255 T DE 602006018255T DE 602006018255 T DE602006018255 T DE 602006018255T DE 602006018255 D1 DE602006018255 D1 DE 602006018255D1
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Prior art keywords
channels
modulators
amino
calcium
activated
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English (en)
Inventor
Ulrik Svane Soerensen
Lene Teuber
Dan Peters
Dorte Stroebak
Tina Holm Johansen
Karin Sandager Nielsen
Palle Christophersen
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NTG Nordic Transport Group AS
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Neurosearch AS
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30Nitrogen atoms not forming part of a nitro radical
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DE602006018255T 2005-01-11 2006-01-10 Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit Active DE602006018255D1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64253805P 2005-01-11 2005-01-11
DKPA200500049 2005-01-11
DKPA200500240 2005-02-16
US65351305P 2005-02-17 2005-02-17
PCT/EP2006/050108 WO2006074991A1 (en) 2005-01-11 2006-01-10 Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels

Publications (1)

Publication Number Publication Date
DE602006018255D1 true DE602006018255D1 (de) 2010-12-30

Family

ID=36010294

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006018255T Active DE602006018255D1 (de) 2005-01-11 2006-01-10 Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit

Country Status (6)

Country Link
US (3) US7842817B2 (de)
EP (2) EP2319512A1 (de)
JP (1) JP2008526815A (de)
AT (1) ATE488235T1 (de)
DE (1) DE602006018255D1 (de)
WO (1) WO2006074991A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007042571A1 (en) * 2005-10-14 2007-04-19 Neurosearch A/S Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
CA2637674A1 (en) * 2006-01-19 2007-07-26 Abbott Laboratories 2-imino-benzimidazoles
WO2008003752A1 (en) * 2006-07-07 2008-01-10 Neurosearch A/S 2 -amino benzimidazole derivatives and their use as modulators of small - conductance calcium -act ivated potassium channels
US8039632B2 (en) * 2006-11-13 2011-10-18 Neurosearch A/S 2-aminio-pyridine derivatives and their use as potassium channel modulators
JP2010509249A (ja) * 2006-11-13 2010-03-25 ノイロサーチ アクティーゼルスカブ 新規な4−アミノ−ピリジン誘導体及びカリウムチャネルモジュレーターとしてのその使用
KR20110097932A (ko) 2008-12-08 2011-08-31 베링거 인겔하임 인터내셔날 게엠베하 암 치료용 화합물
JP2013532149A (ja) * 2010-06-17 2013-08-15 ノバルティス アーゲー ピペリジニル置換1,3−ジヒドロ−ベンゾイミダゾール−2−イリデンアミン誘導体
CN102947274A (zh) * 2010-06-17 2013-02-27 诺瓦提斯公司 联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
EP2810773A1 (de) 2013-06-05 2014-12-10 Basell Poliolefine Italia S.r.l. Buten-1-Copolymer Haftvermittler in Mehrschichtfolienstrukturen mit einer niedrigen Dichtungstemperatur und verbesserte Hot-Tack.
CN105636950A (zh) 2013-10-10 2016-06-01 巴斯夫欧洲公司 取代的n-(四唑-5-基)-和n-(三唑-5-基)芳基羧酰胺化合物及其作为除草剂的用途
WO2016077541A1 (en) * 2014-11-12 2016-05-19 The Trustees Of The University Of Pennsylvania Novel anti-infective compounds and methods using same
CN104744375B (zh) * 2015-02-10 2017-09-19 南开大学 一种胍类ntr1小分子拮抗剂
JP7158464B2 (ja) * 2017-08-14 2022-10-21 アセシオン ファーマ エイピーエス カリウムチャネル阻害剤としての置換ベンゾイミダゾール
ES2885179T3 (es) * 2017-08-23 2021-12-13 Acesion Pharma Aps Derivados de bencimidazol útiles como inhibidores del canal de potasio
MX2020010155A (es) * 2018-03-27 2021-03-25 Univ Texas Compuestos de ox2r.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981886A (en) 1975-01-20 1976-09-21 E. R. Squibb & Sons, Inc. Amino-benzimidazole derivatives
US4004016A (en) 1975-08-11 1977-01-18 E. R. Squibb & Sons, Inc. Amino-benzimidazole derivatives
JP2002519412A (ja) 1998-07-02 2002-07-02 ニューロサーチ、アクティーゼルスカブ カリウムチャンネル遮断剤
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
EP1178977B1 (de) * 1999-05-12 2005-06-01 Neurosearch A/S Ionenkanal modulierende mittel
YU7203A (sh) 2000-08-08 2006-01-16 Sanofi-Aventis Derivati benzimidazola, njihovo dobijanje i terapeutska primena
WO2002066426A2 (en) * 2001-02-20 2002-08-29 Bristol-Myers Squibb Company Fluoro oxindole derivatives as modulators of kcnq potassium channels
DE10135050A1 (de) 2001-07-09 2003-02-06 Schering Ag 1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
WO2003094861A2 (en) 2002-05-13 2003-11-20 Icagen, Inc. Bis-benzimidazoles and related compounds as potassium channel modulators

Also Published As

Publication number Publication date
JP2008526815A (ja) 2008-07-24
US20100280087A1 (en) 2010-11-04
EP1838306A1 (de) 2007-10-03
WO2006074991A1 (en) 2006-07-20
US20080200529A1 (en) 2008-08-21
ATE488235T1 (de) 2010-12-15
US7842817B2 (en) 2010-11-30
US20110034527A1 (en) 2011-02-10
EP1838306B1 (de) 2010-11-17
EP2319512A1 (de) 2011-05-11

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