ATE427927T1 - Phenylacetylenderivate mit affinitat zum mglur5- rezeptor - Google Patents

Phenylacetylenderivate mit affinitat zum mglur5- rezeptor

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Publication number
ATE427927T1
ATE427927T1 AT06724538T AT06724538T ATE427927T1 AT E427927 T1 ATE427927 T1 AT E427927T1 AT 06724538 T AT06724538 T AT 06724538T AT 06724538 T AT06724538 T AT 06724538T AT E427927 T1 ATE427927 T1 AT E427927T1
Authority
AT
Austria
Prior art keywords
affinity
mglur5 receptor
phenylacetylene derivatives
phenylacetylene
derivatives
Prior art date
Application number
AT06724538T
Other languages
English (en)
Inventor
Ralf Glatthar
Thomas Troxler
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE427927T1 publication Critical patent/ATE427927T1/de

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    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
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    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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AT06724538T 2005-04-25 2006-04-24 Phenylacetylenderivate mit affinitat zum mglur5- rezeptor ATE427927T1 (de)

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GBGB0508318.3A GB0508318D0 (en) 2005-04-25 2005-04-25 Organic compounds

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US (1) US20080188490A1 (de)
EP (1) EP1877364B1 (de)
JP (1) JP2008538775A (de)
KR (1) KR20070122224A (de)
CN (1) CN101163662A (de)
AT (1) ATE427927T1 (de)
AU (1) AU2006239545A1 (de)
BR (1) BRPI0610337A2 (de)
CA (1) CA2605262A1 (de)
DE (1) DE602006006170D1 (de)
ES (1) ES2323288T3 (de)
GB (1) GB0508318D0 (de)
MX (1) MX2007013238A (de)
PL (1) PL1877364T3 (de)
PT (1) PT1877364E (de)
RU (1) RU2007143507A (de)
WO (1) WO2006114260A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100381083C (zh) 2003-04-29 2008-04-16 韩力 一种非可燃性电子喷雾香烟
CN2719043Y (zh) * 2004-04-14 2005-08-24 韩力 雾化电子烟
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508319D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
CN201067079Y (zh) * 2006-05-16 2008-06-04 韩力 仿真气溶胶吸入器
CN101854935A (zh) * 2007-10-12 2010-10-06 诺瓦提斯公司 用于治疗帕金森氏病的代谢型谷氨酸受体调节剂
WO2009047303A2 (en) * 2007-10-12 2009-04-16 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder
JPWO2009130900A1 (ja) * 2008-04-24 2011-08-11 日本曹達株式会社 オキシム誘導体、中間体化合物および植物病害防除剤
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US20120142932A1 (en) 2009-09-08 2012-06-07 Koji Kawamura Method for manufacturing 4-(5-methylpyridin-2-ylamino)piperidine-1-carboxylic acid derivative
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
AR080055A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
SG186107A1 (en) * 2010-07-09 2013-01-30 Recordati Ireland Ltd Novel spiroheterocyclic compounds as mglu5 antagonists
US9682953B2 (en) 2011-09-23 2017-06-20 Advinus Therapeutics Limited Amide compounds, compositions and applications thereof
CN105121424B (zh) * 2013-02-18 2019-01-22 华领医药技术（上海）有限公司 mGluR调节剂
KR20180067030A (ko) 2016-12-12 2018-06-20 김성갑 금속판에 다양한 곡면을 성형하는 방법
KR20180067010A (ko) 2016-12-12 2018-06-20 김선권 금속판에 다양한 곡면을 성형하는 방법
WO2020032080A1 (ja) 2018-08-07 2020-02-13 学校法人慶應義塾 化合物、化合物の塩、神経機能調節物質、神経機能調節物質の評価方法、化合物の製造方法、及び化合物の塩の製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991064A (en) * 1975-01-17 1976-11-09 Warner-Lambert Company Benzonaphthyridines
AU6215594A (en) * 1993-03-18 1994-10-11 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
EP0689535B1 (de) * 1993-03-18 1998-09-23 MERCK SHARP & DOHME LTD. Benzimidazole derivate
US5521297A (en) * 1993-06-04 1996-05-28 Salk Institute Biotechnology/Industrial Associates Nucleic acids encoding human metabotropic glutamate receptors
JPH09512542A (ja) * 1994-04-28 1997-12-16 メルク シヤープ エンド ドーム リミテツド Ｄ▲下４▼リセプタ拮抗剤としてのベンゾフラン誘導体
AU699196B2 (en) * 1994-08-10 1998-11-26 Merck Sharp & Dohme Limited Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-b pyridine
US5688798A (en) * 1995-10-10 1997-11-18 Hoffmann-La Roche Inc. Pyrimidine compounds
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
GB0128996D0 (en) * 2001-12-04 2002-01-23 Novartis Ag Organic compounds
US6806279B2 (en) * 2001-12-17 2004-10-19 Sunesis Pharmaceuticals, Inc. Small-molecule inhibitors of interleukin-2
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508319D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds

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GB0508318D0 (en) 2005-06-01
BRPI0610337A2 (pt) 2010-06-15
AU2006239545A1 (en) 2006-11-02
KR20070122224A (ko) 2007-12-28
CN101163662A (zh) 2008-04-16
DE602006006170D1 (de) 2009-05-20
US20080188490A1 (en) 2008-08-07
CA2605262A1 (en) 2006-11-02
WO2006114260A1 (en) 2006-11-02
PL1877364T3 (pl) 2009-09-30
MX2007013238A (es) 2008-01-24
RU2007143507A (ru) 2009-06-10
ES2323288T3 (es) 2009-07-10
EP1877364A1 (de) 2008-01-16
JP2008538775A (ja) 2008-11-06
EP1877364B1 (de) 2009-04-08

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