WO2002066426A3 - Fluoro oxindole derivatives as modulators of kcnq potassium channels - Google Patents

Fluoro oxindole derivatives as modulators of kcnq potassium channels Download PDF

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Publication number
WO2002066426A3
WO2002066426A3 PCT/US2002/004304 US0204304W WO02066426A3 WO 2002066426 A3 WO2002066426 A3 WO 2002066426A3 US 0204304 W US0204304 W US 0204304W WO 02066426 A3 WO02066426 A3 WO 02066426A3
Authority
WO
WIPO (PCT)
Prior art keywords
potassium channels
kcnq potassium
fluoro
modulators
oxindole derivatives
Prior art date
Application number
PCT/US2002/004304
Other languages
French (fr)
Other versions
WO2002066426A2 (en
Inventor
Piyasena Hewawasam
Pierre Dextraze
Valentin K Gribkoff
Gene G Kinney
Steven I Dworetzky
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to EP02714888A priority Critical patent/EP1363624A2/en
Priority to JP2002565943A priority patent/JP2004531483A/en
Priority to CA002438805A priority patent/CA2438805A1/en
Priority to HU0400063A priority patent/HUP0400063A2/en
Publication of WO2002066426A2 publication Critical patent/WO2002066426A2/en
Publication of WO2002066426A3 publication Critical patent/WO2002066426A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

There is provided novel 3-fluoro-3-phenyl oxindole derivatives of Formula I wherein R?1, R2, R3 and R4¿ each are independently hydrogen, C¿1-4? alkyl, halogen, fluoromethyl, trifluoromethyl, phenyl, 4-methylphenyl or 4-trifluoromethylphenyl; R?5¿ is C¿1-6? alkyl optionally substituted with one to three same or different groups selected from fluoro and chloro, provided R?5¿ is not C¿1-6? alkyl when Y is O; Y is O or S; and R?6 and R7¿ each are independently hydrogen, chloro, bromo or trifluoromethy; which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.
PCT/US2002/004304 2001-02-20 2002-02-14 Fluoro oxindole derivatives as modulators of kcnq potassium channels WO2002066426A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02714888A EP1363624A2 (en) 2001-02-20 2002-02-14 Fluoro oxindole derivatives as modulators of kcnq potassium channels
JP2002565943A JP2004531483A (en) 2001-02-20 2002-02-14 Fluoroxindole derivatives as modulators of KCNQ potassium channels
CA002438805A CA2438805A1 (en) 2001-02-20 2002-02-14 Fluoro oxindole derivatives as modulators of kcnq potassium channels
HU0400063A HUP0400063A2 (en) 2001-02-20 2002-02-14 Fluoro oxindole derivatives as modulators of kcnq potassium channels, their use and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27011201P 2001-02-20 2001-02-20
US60/270,112 2001-02-20

Publications (2)

Publication Number Publication Date
WO2002066426A2 WO2002066426A2 (en) 2002-08-29
WO2002066426A3 true WO2002066426A3 (en) 2002-11-21

Family

ID=23029954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/004304 WO2002066426A2 (en) 2001-02-20 2002-02-14 Fluoro oxindole derivatives as modulators of kcnq potassium channels

Country Status (5)

Country Link
EP (1) EP1363624A2 (en)
JP (1) JP2004531483A (en)
CA (1) CA2438805A1 (en)
HU (1) HUP0400063A2 (en)
WO (1) WO2002066426A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072088A2 (en) * 2001-02-20 2002-09-19 Bristol-Myers Squibb Company Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases
JP2006524641A (en) * 2003-04-25 2006-11-02 ハー・ルンドベック・アクチエゼルスカベット Substituted indoline and indole derivatives
WO2005035498A1 (en) * 2003-10-08 2005-04-21 Dainippon Sumitomo Pharma Co., Ltd. Use of nitrogenous bicyclic compound as feeding control agent
EP1838306B1 (en) * 2005-01-11 2010-11-17 NeuroSearch A/S Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
EP2540295A1 (en) * 2011-06-27 2013-01-02 Centre national de la recherche scientifique Compositions for the treatment of Fragile X syndrome
CN110240558B (en) * 2019-07-10 2022-05-27 上海华理生物医药股份有限公司 Novel synthesis method of Flindokalner racemate
EP3912625A1 (en) 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
WO2000034248A1 (en) * 1998-12-04 2000-06-15 Neurosearch A/S New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents
WO2001010380A2 (en) * 1999-08-04 2001-02-15 Icagen, Inc. Benzanilides as potassium channel openers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565483A (en) * 1995-06-07 1996-10-15 Bristol-Myers Squibb Company 3-substituted oxindole derivatives as potassium channel modulators
WO2000034248A1 (en) * 1998-12-04 2000-06-15 Neurosearch A/S New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents
WO2001010380A2 (en) * 1999-08-04 2001-02-15 Icagen, Inc. Benzanilides as potassium channel openers

Also Published As

Publication number Publication date
JP2004531483A (en) 2004-10-14
CA2438805A1 (en) 2002-08-29
WO2002066426A2 (en) 2002-08-29
EP1363624A2 (en) 2003-11-26
HUP0400063A2 (en) 2004-04-28

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