HUP0302648A2 - Biciklusos heteroaromás vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Biciklusos heteroaromás vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0302648A2 HUP0302648A2 HU0302648A HUP0302648A HUP0302648A2 HU P0302648 A2 HUP0302648 A2 HU P0302648A2 HU 0302648 A HU0302648 A HU 0302648A HU P0302648 A HUP0302648 A HU P0302648A HU P0302648 A2 HUP0302648 A2 HU P0302648A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- compounds
- heteroaryl
- aryl
- carbon atom
- Prior art date
Links
- -1 Bicyclic heteroaromatic compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000005915 C6-C14 aryl group Chemical group 0.000 abstract 2
- 102000009151 Luteinizing Hormone Human genes 0.000 abstract 2
- 108010073521 Luteinizing Hormone Proteins 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 2
- 229940040129 luteinizing hormone Drugs 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000126 substance Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány glükoprotein hormon agonista vagy antagonista aktivitásúvegyületekre, közelebbről luteinizáló hormon (LH) agonista aktivitásúbiciklusos heteroaromás vegyületekre vonatkozik. A találmány továbbáilyen vegyületeket tartalmazó gyógyászati készítményekre, valamint azilyen vegyületeknek a gyógyászatban, különösen a termékenységszabályozásában alkalmazható gyógyászati készítmények előállításánálvaló alkalmazására vonatkozik. A találmány szerinti vegyületek (I)általános képletében R1 jelentése 3-8 szénatomos cikloalkil-, 2-7szénatomos heterocikloalkil-, 6-14 szénatomos aril- vagy 4-13szénatomos heteroarilcsoport; előnyösen 6-14 szénatomos aril- vagy 4-13 szénatomos heteroarilcsoport; R2 jelentése 1-4 szénatomos alkil-,2-4 szénatomos alkenil-, 2-4 szénatomos alkinil-, 6-14 szénatomosaril- vagy 4-13 szénatomos heteroarilcsoport; R3 jelentése 1-8szénatomos alkil-, 3-8 szénatomos cikloalkil-, 2-7 szénatomosheterocikloalkil-, 6-14 szénatomos aril- vagy 4-13 szénatomosheteroarilcsoport; Y jelentése metincsoport vagy nitrogénatom; Zjelentése amino- vagy hidroxilcsoport; A jelentése kén- vagyoxigénatom vagy kémiai kötés vagy iminocsoport vagy -N(R4)általánosképletű csoport és ebben a képletben R4 jelentése azonos R2jelentésével; és B jelentése iminocsoport, oxigénatom vagy kémiaikötés. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00203287 | 2000-09-22 | ||
| PCT/EP2001/010743 WO2002024703A1 (en) | 2000-09-22 | 2001-09-17 | Bicyclic heteroaromatic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0302648A2 true HUP0302648A2 (hu) | 2003-11-28 |
| HUP0302648A3 HUP0302648A3 (en) | 2004-11-29 |
| HU229422B1 HU229422B1 (hu) | 2013-12-30 |
Family
ID=8172046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302648A HU229422B1 (hu) | 2000-09-22 | 2001-09-17 | Biciklusos heteroaromás vegyületek |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US7229990B2 (hu) |
| EP (2) | EP1886999A3 (hu) |
| JP (1) | JP4977940B2 (hu) |
| KR (1) | KR100860040B1 (hu) |
| CN (1) | CN1247594C (hu) |
| AR (1) | AR030784A1 (hu) |
| AT (1) | ATE384726T1 (hu) |
| AU (2) | AU2002213929B2 (hu) |
| BR (1) | BR0113987A (hu) |
| CA (1) | CA2422054C (hu) |
| CY (1) | CY1107308T1 (hu) |
| CZ (1) | CZ297136B6 (hu) |
| DE (1) | DE60132607T2 (hu) |
| DK (1) | DK1322651T3 (hu) |
| EC (1) | ECSP034523A (hu) |
| ES (1) | ES2299524T3 (hu) |
| HK (1) | HK1054942A1 (hu) |
| HR (1) | HRP20030220B1 (hu) |
| HU (1) | HU229422B1 (hu) |
| IL (2) | IL154624A0 (hu) |
| IS (1) | IS2531B (hu) |
| MX (1) | MXPA03002478A (hu) |
| NO (1) | NO328683B1 (hu) |
| NZ (1) | NZ524444A (hu) |
| PE (1) | PE20020537A1 (hu) |
| PL (1) | PL207755B1 (hu) |
| PT (1) | PT1322651E (hu) |
| RU (1) | RU2271360C2 (hu) |
| SK (1) | SK287554B6 (hu) |
| TW (1) | TWI290143B (hu) |
| WO (1) | WO2002024703A1 (hu) |
| ZA (1) | ZA200301588B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60132607T2 (de) * | 2000-09-22 | 2009-01-29 | N.V. Organon | Bicyclische heteroaromatische verbindungen |
| TW200407127A (en) | 2002-08-21 | 2004-05-16 | Astrazeneca Ab | Chemical compounds |
| US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
| US7737155B2 (en) * | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| US7723342B2 (en) * | 2005-05-17 | 2010-05-25 | Schering Corporation | Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia |
| WO2007136776A2 (en) * | 2006-05-17 | 2007-11-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pyrimidine low molecular weight ligands for modulating hormone receptors |
| JP5302389B2 (ja) | 2008-04-29 | 2013-10-02 | エフ．ホフマン−ラ ロシュ アーゲー | Ｊｎｋのピリミジニルピリドンインヒビター |
| WO2010047674A1 (en) | 2008-10-20 | 2010-04-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Low molecular weight thyroid stimulating hormone receptor (tshr) agonists |
| CA2789818A1 (en) | 2010-04-08 | 2011-10-13 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Inverse agonists and neutral antagonists for the tsh receptor |
| FI3392252T3 (fi) * | 2011-08-23 | 2024-01-08 | Libertas Bio Inc | Pyrimidopyridazinoniyhdisteet ja niiden käyttö |
| CN113680386B (zh) * | 2021-08-23 | 2023-08-11 | 深圳湾实验室坪山生物医药研发转化中心 | 氮杂环卡宾-方酰胺双功能催化剂及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0765327B1 (en) * | 1994-06-16 | 1999-07-21 | Pfizer Inc. | Pyrazolo and pyrrolopyridines |
| CA2254974A1 (en) * | 1996-05-20 | 1997-11-27 | Mark Goulet | Antagonists of gonadotropin releasing hormone |
| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
| DE60132607T2 (de) * | 2000-09-22 | 2009-01-29 | N.V. Organon | Bicyclische heteroaromatische verbindungen |
-
2001
- 2001-09-17 DE DE60132607T patent/DE60132607T2/de not_active Expired - Lifetime
- 2001-09-17 NZ NZ524444A patent/NZ524444A/en not_active IP Right Cessation
- 2001-09-17 AU AU2002213929A patent/AU2002213929B2/en not_active Ceased
- 2001-09-17 CZ CZ20030828A patent/CZ297136B6/cs not_active IP Right Cessation
- 2001-09-17 HU HU0302648A patent/HU229422B1/hu not_active IP Right Cessation
- 2001-09-17 ES ES01982306T patent/ES2299524T3/es not_active Expired - Lifetime
- 2001-09-17 EP EP07113490A patent/EP1886999A3/en not_active Withdrawn
- 2001-09-17 RU RU2003111463/04A patent/RU2271360C2/ru not_active IP Right Cessation
- 2001-09-17 CA CA2422054A patent/CA2422054C/en not_active Expired - Fee Related
- 2001-09-17 PL PL360675A patent/PL207755B1/pl unknown
- 2001-09-17 BR BR0113987-8A patent/BR0113987A/pt not_active IP Right Cessation
- 2001-09-17 JP JP2002529113A patent/JP4977940B2/ja not_active Expired - Fee Related
- 2001-09-17 AT AT01982306T patent/ATE384726T1/de active
- 2001-09-17 KR KR1020037004132A patent/KR100860040B1/ko not_active IP Right Cessation
- 2001-09-17 MX MXPA03002478A patent/MXPA03002478A/es active IP Right Grant
- 2001-09-17 PT PT01982306T patent/PT1322651E/pt unknown
- 2001-09-17 SK SK331-2003A patent/SK287554B6/sk not_active IP Right Cessation
- 2001-09-17 WO PCT/EP2001/010743 patent/WO2002024703A1/en active IP Right Grant
- 2001-09-17 AU AU1392902A patent/AU1392902A/xx active Pending
- 2001-09-17 DK DK01982306T patent/DK1322651T3/da active
- 2001-09-17 US US10/381,248 patent/US7229990B2/en not_active Expired - Lifetime
- 2001-09-17 CN CNB018160670A patent/CN1247594C/zh not_active Expired - Fee Related
- 2001-09-17 EP EP01982306A patent/EP1322651B1/en not_active Expired - Lifetime
- 2001-09-17 IL IL15462401A patent/IL154624A0/xx unknown
- 2001-09-19 TW TW090123098A patent/TWI290143B/zh not_active IP Right Cessation
- 2001-09-21 PE PE2001000954A patent/PE20020537A1/es not_active Application Discontinuation
- 2001-09-21 AR ARP010104458A patent/AR030784A1/es active IP Right Grant
-
2003
- 2003-02-26 IL IL154624A patent/IL154624A/en not_active IP Right Cessation
- 2003-02-26 ZA ZA200301588A patent/ZA200301588B/en unknown
- 2003-02-28 IS IS6732A patent/IS2531B/is unknown
- 2003-03-21 NO NO20031314A patent/NO328683B1/no not_active IP Right Cessation
- 2003-03-21 HR HR20030220A patent/HRP20030220B1/xx not_active IP Right Cessation
- 2003-03-21 EC EC2003004523A patent/ECSP034523A/es unknown
- 2003-10-13 HK HK03107319A patent/HK1054942A1/xx not_active IP Right Cessation
-
2007
- 2007-04-23 US US11/788,886 patent/US7618963B2/en not_active Expired - Lifetime
-
2008
- 2008-03-18 CY CY20081100301T patent/CY1107308T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: N.V. ORGANON, NL Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL |
|
| GB9A | Succession in title |
Owner name: MSD OSS B.V., NL Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL; N.V. ORGANON, NL |
|
| GB9A | Succession in title |
Owner name: MERCK SHARP & DOHME B.V., NL Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL; MSD OSS B.V., NL; N.V. ORGANON, NL |
|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |