CY1109451T1 - 17βητα-ακυλ-17αλφα-προπυνυλ-11βητα-(κυκλικα αμινο)αρυλ στεροειδη και παραγωγα αυτων που εχουν ιδιοτητες ορμονικου ανταγωνιστη - Google Patents

17βητα-ακυλ-17αλφα-προπυνυλ-11βητα-(κυκλικα αμινο)αρυλ στεροειδη και παραγωγα αυτων που εχουν ιδιοτητες ορμονικου ανταγωνιστη

Info

Publication number
CY1109451T1
CY1109451T1 CY20091100796T CY091100796T CY1109451T1 CY 1109451 T1 CY1109451 T1 CY 1109451T1 CY 20091100796 T CY20091100796 T CY 20091100796T CY 091100796 T CY091100796 T CY 091100796T CY 1109451 T1 CY1109451 T1 CY 1109451T1
Authority
CY
Cyprus
Prior art keywords
acyl
propynyl
17vita
11vita
17alfa
Prior art date
Application number
CY20091100796T
Other languages
English (en)
Inventor
C Edgar Cook
John A Kepler
Jill M O’Reilly
Original Assignee
Research Triangle Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Triangle Institute filed Critical Research Triangle Institute
Publication of CY1109451T1 publication Critical patent/CY1109451T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η εφεύρεση κατευθύνεται σε μία νέα κατηγορία 17b-ακυλ-17a-προπυνύλ στεροειδών που δεικνύουν ισχυρή αντιπρογεστερονική δραστικότητα. Το συνθετικό σχήμα για τη παρασκευή αυτών των ενώσεων δείχνεται στο Σχήμα 1.
CY20091100796T 1999-09-03 2009-07-24 17βητα-ακυλ-17αλφα-προπυνυλ-11βητα-(κυκλικα αμινο)αρυλ στεροειδη και παραγωγα αυτων που εχουν ιδιοτητες ορμονικου ανταγωνιστη CY1109451T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/389,212 US6740645B1 (en) 1999-09-03 1999-09-03 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
EP00959867A EP1208113B1 (en) 1999-09-03 2000-09-05 17beta-acyl-alpha-propynyl-11beta-(cyclic amino)aryl steroids and their derivatives having antagonist hormonal properties

Publications (1)

Publication Number Publication Date
CY1109451T1 true CY1109451T1 (el) 2014-08-13

Family

ID=23537322

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100796T CY1109451T1 (el) 1999-09-03 2009-07-24 17βητα-ακυλ-17αλφα-προπυνυλ-11βητα-(κυκλικα αμινο)αρυλ στεροειδη και παραγωγα αυτων που εχουν ιδιοτητες ορμονικου ανταγωνιστη

Country Status (14)

Country Link
US (1) US6740645B1 (el)
EP (1) EP1208113B1 (el)
JP (1) JP4837858B2 (el)
KR (1) KR100733932B1 (el)
AT (1) ATE431832T1 (el)
AU (1) AU780077B2 (el)
CA (1) CA2384184C (el)
CY (1) CY1109451T1 (el)
DE (1) DE60042238D1 (el)
DK (1) DK1208113T3 (el)
ES (1) ES2326787T3 (el)
NO (1) NO322108B1 (el)
PT (1) PT1208113E (el)
WO (1) WO2001018025A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US6861415B2 (en) 1996-05-01 2005-03-01 The United States Of America As Represented By The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
ES2307604T3 (es) * 2000-03-17 2008-12-01 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services 19-norpregnadienodiona 17-a sustituidos, 11-b-sustituido-4-arilo y 21-sustituidos como nuevos agentes antiprogestacionales.
AU2004217988C1 (en) * 2003-02-28 2010-06-03 Southwest Foundation For Biomedical Research Method for preparing 17 alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
WO2011119194A1 (en) * 2010-03-22 2011-09-29 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins
CN103130862B (zh) * 2011-11-30 2016-04-13 成都伊诺达博医药科技有限公司 醋酸乌利司他关键中间体3,20-双(亚乙二氧基)-19-去甲孕甾-5,9-二烯-17-醇的合成方法
NZ702467A (en) 2012-05-31 2016-07-29 Repros Therapeutics Inc Formulations and methods for vaginal delivery of antiprogestins
ES2688821T3 (es) 2012-11-02 2018-11-07 Repros Therapeutics Inc. Métodos y composiciones para tratar afecciones dependientes de la progesterona
US9850273B2 (en) * 2014-12-03 2017-12-26 Evestra, Inc. Combination of estrogens plus antiprogestins with significant partial agonistic effect as an effective treatment of menopausal symptoms and for prevention of the occurrence of breast cancer
CN115521352B (zh) * 2022-11-01 2024-05-14 湖南新合新生物医药有限公司 一种甲基双烯醇酮的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954490A (en) 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
US6861415B2 (en) * 1996-05-01 2005-03-01 The United States Of America As Represented By The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
IL122740A (en) 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties

Also Published As

Publication number Publication date
ATE431832T1 (de) 2009-06-15
WO2001018025A3 (en) 2001-09-20
PT1208113E (pt) 2009-08-25
NO20021037L (no) 2002-04-05
EP1208113A2 (en) 2002-05-29
JP2003508540A (ja) 2003-03-04
CA2384184A1 (en) 2001-03-15
ES2326787T3 (es) 2009-10-20
KR100733932B1 (ko) 2007-07-03
NO322108B1 (no) 2006-08-14
EP1208113B1 (en) 2009-05-20
EP1208113A4 (en) 2003-01-02
WO2001018025A2 (en) 2001-03-15
DK1208113T3 (da) 2009-08-31
KR20020092906A (ko) 2002-12-12
NO20021037D0 (no) 2002-03-01
AU7111300A (en) 2001-04-10
CA2384184C (en) 2008-07-08
JP4837858B2 (ja) 2011-12-14
DE60042238D1 (de) 2009-07-02
US6740645B1 (en) 2004-05-25
AU780077B2 (en) 2005-02-24

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