ATE431832T1 - 17beta-acyl-17alpha-propynyl-11beta- (cycloamino)aryl-steroide und ihre derivate mit hormon-antagonistischen eigenschaften - Google Patents

17beta-acyl-17alpha-propynyl-11beta- (cycloamino)aryl-steroide und ihre derivate mit hormon-antagonistischen eigenschaften

Info

Publication number
ATE431832T1
ATE431832T1 AT00959867T AT00959867T ATE431832T1 AT E431832 T1 ATE431832 T1 AT E431832T1 AT 00959867 T AT00959867 T AT 00959867T AT 00959867 T AT00959867 T AT 00959867T AT E431832 T1 ATE431832 T1 AT E431832T1
Authority
AT
Austria
Prior art keywords
17alpha
17beta
acyl
propynyl
cycloamino
Prior art date
Application number
AT00959867T
Other languages
English (en)
Inventor
C Edgar Cook
John A Kepler
Jill M O'reilly
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Application granted granted Critical
Publication of ATE431832T1 publication Critical patent/ATE431832T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00959867T 1999-09-03 2000-09-05 17beta-acyl-17alpha-propynyl-11beta- (cycloamino)aryl-steroide und ihre derivate mit hormon-antagonistischen eigenschaften ATE431832T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/389,212 US6740645B1 (en) 1999-09-03 1999-09-03 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
PCT/US2000/024274 WO2001018025A2 (en) 1999-09-03 2000-09-05 17alpha propynyl 11-aryl steroids

Publications (1)

Publication Number Publication Date
ATE431832T1 true ATE431832T1 (de) 2009-06-15

Family

ID=23537322

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00959867T ATE431832T1 (de) 1999-09-03 2000-09-05 17beta-acyl-17alpha-propynyl-11beta- (cycloamino)aryl-steroide und ihre derivate mit hormon-antagonistischen eigenschaften

Country Status (14)

Country Link
US (1) US6740645B1 (de)
EP (1) EP1208113B1 (de)
JP (1) JP4837858B2 (de)
KR (1) KR100733932B1 (de)
AT (1) ATE431832T1 (de)
AU (1) AU780077B2 (de)
CA (1) CA2384184C (de)
CY (1) CY1109451T1 (de)
DE (1) DE60042238D1 (de)
DK (1) DK1208113T3 (de)
ES (1) ES2326787T3 (de)
NO (1) NO322108B1 (de)
PT (1) PT1208113E (de)
WO (1) WO2001018025A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2668824A1 (en) 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secre Tary Of The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
AU4584901A (en) * 2000-03-17 2001-10-15 Us Gov Health & Human Serv Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
WO2004078709A2 (en) * 2003-02-28 2004-09-16 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services METHOD FOR PREPARING 17 α-ACETOXY-11β-(4-N,N-DIMETHYLAMINOPHENYL)-19-NORPREGNA-4,9-DIENE-3,20-DIONE, INTERMEDIATES THEREOF, AND METHODS FOR THE PREPARATION OF SUCH INTERMEDIATES
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
JP5894143B2 (ja) * 2010-03-22 2016-03-23 リプロス セラピューティクス インコーポレイテッド 抗黄体ホルモンの無毒送達のための組成物および方法
CN103130862B (zh) * 2011-11-30 2016-04-13 成都伊诺达博医药科技有限公司 醋酸乌利司他关键中间体3,20-双(亚乙二氧基)-19-去甲孕甾-5,9-二烯-17-醇的合成方法
NZ702467A (en) 2012-05-31 2016-07-29 Repros Therapeutics Inc Formulations and methods for vaginal delivery of antiprogestins
CN104755087A (zh) 2012-11-02 2015-07-01 利普生物药剂公司 治疗孕酮依赖性病况的方法和组合物
US9850273B2 (en) * 2014-12-03 2017-12-26 Evestra, Inc. Combination of estrogens plus antiprogestins with significant partial agonistic effect as an effective treatment of menopausal symptoms and for prevention of the occurrence of breast cancer
CN115521352B (zh) * 2022-11-01 2024-05-14 湖南新合新生物医药有限公司 一种甲基双烯醇酮的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954490A (en) 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
CA2668824A1 (en) * 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secre Tary Of The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
IL122740A (en) 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties

Also Published As

Publication number Publication date
NO322108B1 (no) 2006-08-14
EP1208113A2 (de) 2002-05-29
DE60042238D1 (de) 2009-07-02
CA2384184A1 (en) 2001-03-15
US6740645B1 (en) 2004-05-25
JP4837858B2 (ja) 2011-12-14
WO2001018025A2 (en) 2001-03-15
AU780077B2 (en) 2005-02-24
EP1208113B1 (de) 2009-05-20
JP2003508540A (ja) 2003-03-04
KR100733932B1 (ko) 2007-07-03
PT1208113E (pt) 2009-08-25
CY1109451T1 (el) 2014-08-13
DK1208113T3 (da) 2009-08-31
ES2326787T3 (es) 2009-10-20
NO20021037L (no) 2002-04-05
CA2384184C (en) 2008-07-08
KR20020092906A (ko) 2002-12-12
WO2001018025A3 (en) 2001-09-20
AU7111300A (en) 2001-04-10
NO20021037D0 (no) 2002-03-01
EP1208113A4 (de) 2003-01-02

Similar Documents

Publication Publication Date Title
CY1109451T1 (el) 17βητα-ακυλ-17αλφα-προπυνυλ-11βητα-(κυκλικα αμινο)αρυλ στεροειδη και παραγωγα αυτων που εχουν ιδιοτητες ορμονικου ανταγωνιστη
NO20013369D0 (no) Arylpiperazinyl-cykloheksyl-indol-derivater for behandling av depresjon
DE69925133D1 (de) Pyrrolobenzodiazepine
NO20001962D0 (no) Terapeutisk anvendelse av kinolinderivater
EE200200349A (et) Antiprogestiinsete omadustega ravimite manustamise vahendid
CY1111317T1 (el) Παραγωγα 4-φαινυλοπυριδινης και χρηση αυτων ως ανταγωνιστων υποδοχεων της νκ-1
MXPA00008738A (es) 20-ceto-1 1b-arilesteroides y sus derivados teniendo propiedades agonistas o antagonistas hormonales.
HRP20080467A2 (en) 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia
NO20025792L (no) Kinazolinderivater for behandling av tumorer
CY1106443T1 (el) 17β-αμινο και υδροξυλαμινο -11β- αρυλστepοειδη και παραγωγα αυτων που εχουν αγωνιστη ή ανταγωνιστη ορμονικες ιδιοτητες
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
NO20054715L (no) Fremgangsmater og mellomprodukter for fremstilling av anti-cancer forbindelser
NO20013380L (no) 2-aminobenzoksazinonderivater for behandling av fedme
NO20021400L (no) Terapeutiske kinazolinderivater
DE60137307D1 (de) Substituierte sapogenine und ihre verwendung
IT1285770B1 (it) Composti corticoidei
NO20021860D0 (no) Formulering av substituerte benzimidazoler
ATE246201T1 (de) 17beta-acyl-17alpha-propynyl-11beta-arylsteroid und ihre derivate mit agonistischen oder antagonistischen hormonalen aktivitäten
DE69821988D1 (de) Substituierte isochinoline derivate und ihre verwendung als anticonvulsiva
PT1196428E (pt) Esteroides substituidos com 11 beta-aril-17, 17-espirotiolano
DE69124482D1 (de) Azolylmethyloxabicyclohexane Derivate, ihre Zwischenprodukte und fungizide Zusammensetzungen
DE60026608D1 (de) 3-methylen steroid derivate zur behandlung von autoimmunerkrankungen
HUP9902810A2 (hu) Bradikinin antagonista hatású 1,4-dihidro-piridin-származékok
SE9901273D0 (sv) Novel compounds
SE9904449D0 (sv) Activtor of the vanilloid receptor

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1208113

Country of ref document: EP