CY1106443T1 - 17β-αμινο και υδροξυλαμινο -11β- αρυλστepοειδη και παραγωγα αυτων που εχουν αγωνιστη ή ανταγωνιστη ορμονικες ιδιοτητες - Google Patents
17β-αμινο και υδροξυλαμινο -11β- αρυλστepοειδη και παραγωγα αυτων που εχουν αγωνιστη ή ανταγωνιστη ορμονικες ιδιοτητεςInfo
- Publication number
- CY1106443T1 CY1106443T1 CY20061101454T CY061101454T CY1106443T1 CY 1106443 T1 CY1106443 T1 CY 1106443T1 CY 20061101454 T CY20061101454 T CY 20061101454T CY 061101454 T CY061101454 T CY 061101454T CY 1106443 T1 CY1106443 T1 CY 1106443T1
- Authority
- CY
- Cyprus
- Prior art keywords
- arylstepoides
- hydroxylamino
- antagonist
- derivatives
- amino
- Prior art date
Links
- -1 HYDROXYLAMINO Chemical class 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Abstract
Η εφεύρεση κατευθύνεται σε μια νέα κατηγορία στεροειδών τα οποία δεικνύουν ισχυρή αντιπροεμμηνοροϊκή δραστικότητα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/086,560 US6262042B1 (en) | 1998-05-29 | 1998-05-29 | 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
PCT/US1999/010480 WO1999062928A1 (en) | 1998-05-29 | 1999-05-28 | 17β-AMINO AND HYDROXYLAMINO-11β-ARYLSTEROIDS AND THEIR DERIVATIVES HAVING AGONIST OR ANTAGONIST HORMONAL PROPERTIES |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106443T1 true CY1106443T1 (el) | 2011-10-12 |
Family
ID=22199388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101454T CY1106443T1 (el) | 1998-05-29 | 2006-10-12 | 17β-αμινο και υδροξυλαμινο -11β- αρυλστepοειδη και παραγωγα αυτων που εχουν αγωνιστη ή ανταγωνιστη ορμονικες ιδιοτητες |
Country Status (25)
Country | Link |
---|---|
US (3) | US6262042B1 (el) |
EP (1) | EP1082337B1 (el) |
JP (1) | JP4545929B2 (el) |
KR (1) | KR100611289B1 (el) |
CN (1) | CN100357311C (el) |
AT (1) | ATE333462T1 (el) |
AU (1) | AU753382B2 (el) |
BR (1) | BR9910794A (el) |
CA (1) | CA2333669C (el) |
CY (1) | CY1106443T1 (el) |
CZ (1) | CZ300313B6 (el) |
DE (1) | DE69932432T8 (el) |
DK (1) | DK1082337T3 (el) |
ES (1) | ES2270596T3 (el) |
HK (1) | HK1035196A1 (el) |
HU (1) | HU228770B1 (el) |
ID (1) | ID26885A (el) |
IL (1) | IL139861A (el) |
NO (1) | NO317988B1 (el) |
NZ (1) | NZ507985A (el) |
PL (1) | PL198055B1 (el) |
PT (1) | PT1082337E (el) |
RU (1) | RU2238943C2 (el) |
SK (1) | SK285748B6 (el) |
WO (1) | WO1999062928A1 (el) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6262042B1 (en) * | 1998-05-29 | 2001-07-17 | Research Triangle Institute | 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
ES2190373B1 (es) * | 2001-12-07 | 2004-10-16 | J. URIACH & CIA, S.A. | Uso del acido 2-hidroxi- o 2-acetiloxi-4-trifluorometilbenzoico como agente para el tratamiento y prevencion del deterioro cognitivo ligero. |
CN100439361C (zh) | 2003-03-07 | 2008-12-03 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
EP1601669B1 (en) | 2003-03-07 | 2008-12-24 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US8097606B2 (en) * | 2003-07-23 | 2012-01-17 | Corcept Therapeutics, Inc. | Antiglucocorticoids for the treatment of catatonia |
US20070249573A1 (en) * | 2006-04-13 | 2007-10-25 | Gerd Schubert | 17alpha-substituted 4-(3-oxoestra-4,9-dien-11beta-yl)-benzoic acid, its derivatives and process for its production |
US9517240B2 (en) | 2006-09-26 | 2016-12-13 | The Regents Of The University Of California | Methods and compositions for cancer prevention and treatment |
US20100160275A1 (en) * | 2006-09-26 | 2010-06-24 | Lee Eva Y H P | Methods and compositions for cancer prevention and treatment |
US8299050B2 (en) * | 2008-01-29 | 2012-10-30 | Laboratoire Hra-Pharma | Method for treating uterine fibroids |
US8778969B2 (en) * | 2009-11-07 | 2014-07-15 | Peter H Proctor | Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines |
US9096641B2 (en) * | 2013-06-05 | 2015-08-04 | Evestra, Inc. | Imidazolyl progesterone antagonists |
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DE289539C (el) | ||||
DE287510C (el) | ||||
DE290198C (el) | ||||
US3187022A (en) * | 1964-01-31 | 1965-06-01 | Parke Davis & Co | 17beta-amino-17alpha-pregnen-20-one compounds and the production thereof |
US4686085A (en) * | 1980-04-14 | 1987-08-11 | Thomas Jefferson University | Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
ZA8231B (en) | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
FR2522328B1 (fr) | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
DE3306121A1 (de) * | 1983-02-18 | 1984-09-06 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-spirolaktone in der steroidreihe, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische praeparate |
EP0116974B1 (de) * | 1983-02-18 | 1986-10-29 | Schering Aktiengesellschaft | 11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate |
DE3347126A1 (de) | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
US4481144A (en) | 1984-02-03 | 1984-11-06 | E. R. Squibb & Sons, Inc. | 17-Substituted thia-17-alkyl(or alkenyl or alkynyl)androstenes |
US4529548A (en) | 1984-05-07 | 1985-07-16 | E. R. Squibb & Sons, Inc. | 17β-(substituted thio)androstenes |
NZ214998A (en) | 1985-02-07 | 1989-06-28 | Schering Ag | 13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions |
DE3506785A1 (de) | 1985-02-22 | 1986-08-28 | Schering AG, Berlin und Bergkamen, 1000 Berlin | 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
FR2596395B1 (fr) | 1986-03-26 | 1989-05-26 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
FR2598421B1 (fr) | 1986-05-06 | 1988-08-19 | Roussel Uclaf | Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
DE3625315A1 (de) | 1986-07-25 | 1988-01-28 | Schering Ag | 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate |
US4861763A (en) | 1986-09-17 | 1989-08-29 | Research Triangle Institute | 17 α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and their progestational use |
US4774236A (en) | 1986-09-17 | 1988-09-27 | Research Triangle Institute | 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them |
DE3702383A1 (de) | 1987-01-23 | 1988-08-04 | Schering Ag | 11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
IE60780B1 (en) | 1987-01-23 | 1994-08-10 | Akzo Nv | New 11-aryl steroid derivatives |
FR2610933B1 (fr) | 1987-02-18 | 1989-06-09 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant |
ATE69820T1 (de) | 1987-04-24 | 1991-12-15 | Akzo Nv | 11-arylestranderivate und 11-arylpregnanderivate. |
FR2618783B1 (fr) | 1987-07-30 | 1991-02-01 | Roussel Uclaf | Nouveaux 17-aryle steroides, leurs procedes et des intermediaires de preparation comme medicaments et les compositions pharmaceutiques les renfermant |
DE3878198T2 (de) | 1987-12-12 | 1993-06-24 | Akzo Nv | 11-arylsteroid-derivate. |
US4954490A (en) * | 1988-06-23 | 1990-09-04 | Research Triangle Institute | 11 β-substituted progesterone analogs |
DE3822770A1 (de) | 1988-07-01 | 1990-01-04 | Schering Ag | 13-alkyl-11ss-phenylgonane |
FR2643638B1 (fr) | 1989-02-24 | 1991-06-14 | Roussel Uclaf | Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
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ATE172469T1 (de) | 1989-08-04 | 1998-11-15 | Schering Ag | 11 beta-aryl-gona-4,9-dien-3-one |
DE4042005A1 (de) | 1990-12-22 | 1992-06-25 | Schering Ag | D-homo-(16-en)-11(beta)-aryl-4-estrene |
ZA929315B (en) | 1991-12-20 | 1993-05-24 | Akzo Nv | 17-spirofuran-3'-ylidene steroids. |
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CA2253673C (en) | 1996-05-01 | 2009-09-08 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
US6020328A (en) | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US5962444A (en) | 1998-05-29 | 1999-10-05 | Research Triangle Institute | 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6262042B1 (en) | 1998-05-29 | 2001-07-17 | Research Triangle Institute | 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6172052B1 (en) | 1998-12-04 | 2001-01-09 | Research Triangle Institute | 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6043235A (en) | 1999-07-21 | 2000-03-28 | Research Triangle Institute | 11β-aryl-17, 17-spirothiolane-substituted steroids |
-
1998
- 1998-05-29 US US09/086,560 patent/US6262042B1/en not_active Expired - Lifetime
-
1999
- 1999-05-28 AU AU40761/99A patent/AU753382B2/en not_active Expired
- 1999-05-28 ID IDW20002450A patent/ID26885A/id unknown
- 1999-05-28 DE DE69932432T patent/DE69932432T8/de active Active
- 1999-05-28 AT AT99924207T patent/ATE333462T1/de active
- 1999-05-28 EP EP99924207A patent/EP1082337B1/en not_active Expired - Lifetime
- 1999-05-28 HU HU0103109A patent/HU228770B1/hu unknown
- 1999-05-28 DK DK99924207T patent/DK1082337T3/da active
- 1999-05-28 IL IL13986199A patent/IL139861A/xx not_active IP Right Cessation
- 1999-05-28 RU RU2000133319A patent/RU2238943C2/ru active
- 1999-05-28 JP JP2000552138A patent/JP4545929B2/ja not_active Expired - Lifetime
- 1999-05-28 ES ES99924207T patent/ES2270596T3/es not_active Expired - Lifetime
- 1999-05-28 NZ NZ507985A patent/NZ507985A/en not_active IP Right Cessation
- 1999-05-28 PL PL344413A patent/PL198055B1/pl unknown
- 1999-05-28 CZ CZ20004446A patent/CZ300313B6/cs not_active IP Right Cessation
- 1999-05-28 WO PCT/US1999/010480 patent/WO1999062928A1/en active IP Right Grant
- 1999-05-28 BR BR9910794-5A patent/BR9910794A/pt not_active Application Discontinuation
- 1999-05-28 SK SK1809-2000A patent/SK285748B6/sk not_active IP Right Cessation
- 1999-05-28 KR KR1020007013416A patent/KR100611289B1/ko not_active IP Right Cessation
- 1999-05-28 CA CA002333669A patent/CA2333669C/en not_active Expired - Lifetime
- 1999-05-28 PT PT99924207T patent/PT1082337E/pt unknown
- 1999-05-28 CN CNB998068012A patent/CN100357311C/zh not_active Expired - Lifetime
-
2000
- 2000-11-27 NO NO20005989A patent/NO317988B1/no not_active IP Right Cessation
-
2001
- 2001-07-02 US US09/895,395 patent/US6620801B2/en not_active Expired - Lifetime
- 2001-08-23 HK HK01105957A patent/HK1035196A1/xx not_active IP Right Cessation
-
2003
- 2003-07-02 US US10/611,785 patent/US7018991B2/en not_active Expired - Lifetime
-
2006
- 2006-10-12 CY CY20061101454T patent/CY1106443T1/el unknown
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