NO322108B1 - 17<beta>-acyl-17<alfa>-propynyl-11<beta>-(cyklisk amino) arylsteroider og dere derivater som har hormonelle antagonistegenskaper - Google Patents
17<beta>-acyl-17<alfa>-propynyl-11<beta>-(cyklisk amino) arylsteroider og dere derivater som har hormonelle antagonistegenskaper Download PDFInfo
- Publication number
- NO322108B1 NO322108B1 NO20021037A NO20021037A NO322108B1 NO 322108 B1 NO322108 B1 NO 322108B1 NO 20021037 A NO20021037 A NO 20021037A NO 20021037 A NO20021037 A NO 20021037A NO 322108 B1 NO322108 B1 NO 322108B1
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- Prior art keywords
- norpregna
- phenyl
- dien
- dione
- methyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/389,212 US6740645B1 (en) | 1999-09-03 | 1999-09-03 | 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties |
| PCT/US2000/024274 WO2001018025A2 (en) | 1999-09-03 | 2000-09-05 | 17alpha propynyl 11-aryl steroids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20021037D0 NO20021037D0 (no) | 2002-03-01 |
| NO20021037L NO20021037L (no) | 2002-04-05 |
| NO322108B1 true NO322108B1 (no) | 2006-08-14 |
Family
ID=23537322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021037A NO322108B1 (no) | 1999-09-03 | 2002-03-01 | 17<beta>-acyl-17<alfa>-propynyl-11<beta>-(cyklisk amino) arylsteroider og dere derivater som har hormonelle antagonistegenskaper |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6740645B1 (de) |
| EP (1) | EP1208113B1 (de) |
| JP (1) | JP4837858B2 (de) |
| KR (1) | KR100733932B1 (de) |
| AT (1) | ATE431832T1 (de) |
| AU (1) | AU780077B2 (de) |
| CA (1) | CA2384184C (de) |
| CY (1) | CY1109451T1 (de) |
| DE (1) | DE60042238D1 (de) |
| DK (1) | DK1208113T3 (de) |
| ES (1) | ES2326787T3 (de) |
| NO (1) | NO322108B1 (de) |
| PT (1) | PT1208113E (de) |
| WO (1) | WO2001018025A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861415B2 (en) | 1996-05-01 | 2005-03-01 | The United States Of America As Represented By The Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
| US6900193B1 (en) | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
| WO2001074840A2 (en) * | 2000-03-17 | 2001-10-11 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregna 21-substituted 19-norpregnadienedione as antiprogestational agents |
| EP1613640A4 (de) * | 2003-02-28 | 2010-05-19 | Us Gov Health & Human Serv | Verfahren zur herstellung von 17 alpha-acetoxy-11 beta-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-dien-3,20-dion, zwischenprodukte dafür, und verfahren zur herstellung dieser zwischenprodukte |
| TWI477276B (zh) | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | 抗黃體素給藥方案 |
| KR102166867B1 (ko) * | 2010-03-22 | 2020-10-19 | 앨러간 파마슈티컬스 인터내셔널 리미티드 | 항프로게스틴의 비독성 전달을 위한 조성물들과 그 방법들 |
| CN103130862B (zh) * | 2011-11-30 | 2016-04-13 | 成都伊诺达博医药科技有限公司 | 醋酸乌利司他关键中间体3,20-双(亚乙二氧基)-19-去甲孕甾-5,9-二烯-17-醇的合成方法 |
| ES2701400T3 (es) | 2012-05-31 | 2019-02-22 | Repros Therapeutics Inc | Formulaciones para la administración vaginal de antiprogestinas |
| JP6343619B2 (ja) | 2012-11-02 | 2018-06-13 | レプロス セラピューティクス インコーポレイティド | プロゲステロン依存性病態を処置する方法およびその組成物 |
| WO2016090139A1 (en) * | 2014-12-03 | 2016-06-09 | Evestra, Inc. | Combination of estrogens plus antiprogestins with significant partial agonistic effect as an effective treatment of menopausal symptoms and for prevention of the occurrence of breast cancer |
| CN115521352B (zh) * | 2022-11-01 | 2024-05-14 | 湖南新合新生物医药有限公司 | 一种甲基双烯醇酮的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954490A (en) | 1988-06-23 | 1990-09-04 | Research Triangle Institute | 11 β-substituted progesterone analogs |
| US6861415B2 (en) * | 1996-05-01 | 2005-03-01 | The United States Of America As Represented By The Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
| IL122740A (en) | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| US5952319A (en) | 1997-11-26 | 1999-09-14 | Research Triangle Institute | Androgenic steroid compounds and a method of making and using the same |
| US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
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1999
- 1999-09-03 US US09/389,212 patent/US6740645B1/en not_active Expired - Lifetime
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2000
- 2000-09-05 DK DK00959867T patent/DK1208113T3/da active
- 2000-09-05 KR KR1020027002738A patent/KR100733932B1/ko not_active IP Right Cessation
- 2000-09-05 ES ES00959867T patent/ES2326787T3/es not_active Expired - Lifetime
- 2000-09-05 PT PT00959867T patent/PT1208113E/pt unknown
- 2000-09-05 WO PCT/US2000/024274 patent/WO2001018025A2/en active IP Right Grant
- 2000-09-05 AU AU71113/00A patent/AU780077B2/en not_active Ceased
- 2000-09-05 CA CA002384184A patent/CA2384184C/en not_active Expired - Fee Related
- 2000-09-05 EP EP00959867A patent/EP1208113B1/de not_active Expired - Lifetime
- 2000-09-05 JP JP2001522248A patent/JP4837858B2/ja not_active Expired - Fee Related
- 2000-09-05 DE DE60042238T patent/DE60042238D1/de not_active Expired - Lifetime
- 2000-09-05 AT AT00959867T patent/ATE431832T1/de active
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2002
- 2002-03-01 NO NO20021037A patent/NO322108B1/no not_active IP Right Cessation
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2009
- 2009-07-24 CY CY20091100796T patent/CY1109451T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100733932B1 (ko) | 2007-07-03 |
| JP2003508540A (ja) | 2003-03-04 |
| AU780077B2 (en) | 2005-02-24 |
| KR20020092906A (ko) | 2002-12-12 |
| NO20021037L (no) | 2002-04-05 |
| NO20021037D0 (no) | 2002-03-01 |
| DK1208113T3 (da) | 2009-08-31 |
| EP1208113A4 (de) | 2003-01-02 |
| JP4837858B2 (ja) | 2011-12-14 |
| CA2384184A1 (en) | 2001-03-15 |
| US6740645B1 (en) | 2004-05-25 |
| CY1109451T1 (el) | 2014-08-13 |
| WO2001018025A3 (en) | 2001-09-20 |
| EP1208113B1 (de) | 2009-05-20 |
| WO2001018025A2 (en) | 2001-03-15 |
| PT1208113E (pt) | 2009-08-25 |
| AU7111300A (en) | 2001-04-10 |
| ES2326787T3 (es) | 2009-10-20 |
| EP1208113A2 (de) | 2002-05-29 |
| ATE431832T1 (de) | 2009-06-15 |
| DE60042238D1 (de) | 2009-07-02 |
| CA2384184C (en) | 2008-07-08 |
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