NO20021037L - 17<beta>-acyl-17<alfa>-propynyl-11<beta>-(cyklisk amino) arylsteroider og dere derivater som har hormonelleantagonistegenskaper - Google Patents

17<beta>-acyl-17<alfa>-propynyl-11<beta>-(cyklisk amino) arylsteroider og dere derivater som har hormonelleantagonistegenskaper

Info

Publication number
NO20021037L
NO20021037L NO20021037A NO20021037A NO20021037L NO 20021037 L NO20021037 L NO 20021037L NO 20021037 A NO20021037 A NO 20021037A NO 20021037 A NO20021037 A NO 20021037A NO 20021037 L NO20021037 L NO 20021037L
Authority
NO
Norway
Prior art keywords
beta
acyl
propynyl
alfa
derivatives
Prior art date
Application number
NO20021037A
Other languages
English (en)
Other versions
NO322108B1 (no
NO20021037D0 (no
Inventor
C Edgar Cook
John A Kepler
Jill M O'reilly
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Publication of NO20021037D0 publication Critical patent/NO20021037D0/no
Publication of NO20021037L publication Critical patent/NO20021037L/no
Publication of NO322108B1 publication Critical patent/NO322108B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20021037A 1999-09-03 2002-03-01 17<beta>-acyl-17<alfa>-propynyl-11<beta>-(cyklisk amino) arylsteroider og dere derivater som har hormonelle antagonistegenskaper NO322108B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/389,212 US6740645B1 (en) 1999-09-03 1999-09-03 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
PCT/US2000/024274 WO2001018025A2 (en) 1999-09-03 2000-09-05 17alpha propynyl 11-aryl steroids

Publications (3)

Publication Number Publication Date
NO20021037D0 NO20021037D0 (no) 2002-03-01
NO20021037L true NO20021037L (no) 2002-04-05
NO322108B1 NO322108B1 (no) 2006-08-14

Family

ID=23537322

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021037A NO322108B1 (no) 1999-09-03 2002-03-01 17<beta>-acyl-17<alfa>-propynyl-11<beta>-(cyklisk amino) arylsteroider og dere derivater som har hormonelle antagonistegenskaper

Country Status (14)

Country Link
US (1) US6740645B1 (no)
EP (1) EP1208113B1 (no)
JP (1) JP4837858B2 (no)
KR (1) KR100733932B1 (no)
AT (1) ATE431832T1 (no)
AU (1) AU780077B2 (no)
CA (1) CA2384184C (no)
CY (1) CY1109451T1 (no)
DE (1) DE60042238D1 (no)
DK (1) DK1208113T3 (no)
ES (1) ES2326787T3 (no)
NO (1) NO322108B1 (no)
PT (1) PT1208113E (no)
WO (1) WO2001018025A2 (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
CA2668824A1 (en) 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secre Tary Of The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
ES2546291T3 (es) * 2000-03-17 2015-09-22 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 17-Alfa-sustituida, 11-beta-sustituida-4-arilo y 21-sustituida 19-norpregnadienodionas como agentes antiprogestacionales
EP1613640A4 (en) * 2003-02-28 2010-05-19 Us Gov Health & Human Serv PROCESS FOR PREPARING 17 ALPHA-ACETOXY-11 BETA- (4-N, N-DIMETHYLAMINOPHENYL) -19-NORPREGNA-4,9-DIENE-3,20-DION, INTERMEDIATE PRODUCTS AND METHOD OF MANUFACTURING THESE INTERMEDIATE PRODUCTS
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
NZ602525A (en) * 2010-03-22 2014-01-31 Repros Therapeutics Inc Compositions and methods for non-toxic delivery of antiprogestins
CN103130862B (zh) * 2011-11-30 2016-04-13 成都伊诺达博医药科技有限公司 醋酸乌利司他关键中间体3,20-双(亚乙二氧基)-19-去甲孕甾-5,9-二烯-17-醇的合成方法
US10328022B2 (en) 2012-05-31 2019-06-25 Repros Therapeutics Inc. Formulations and methods for vaginal delivery of antiprogestins
WO2014070517A1 (en) 2012-11-02 2014-05-08 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions
US9850273B2 (en) * 2014-12-03 2017-12-26 Evestra, Inc. Combination of estrogens plus antiprogestins with significant partial agonistic effect as an effective treatment of menopausal symptoms and for prevention of the occurrence of breast cancer
CN115521352B (zh) * 2022-11-01 2024-05-14 湖南新合新生物医药有限公司 一种甲基双烯醇酮的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954490A (en) 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
CA2668824A1 (en) * 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secre Tary Of The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
IL122740A (en) 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties

Also Published As

Publication number Publication date
EP1208113A4 (en) 2003-01-02
KR20020092906A (ko) 2002-12-12
US6740645B1 (en) 2004-05-25
WO2001018025A2 (en) 2001-03-15
PT1208113E (pt) 2009-08-25
CY1109451T1 (el) 2014-08-13
ATE431832T1 (de) 2009-06-15
JP2003508540A (ja) 2003-03-04
EP1208113B1 (en) 2009-05-20
ES2326787T3 (es) 2009-10-20
DE60042238D1 (de) 2009-07-02
KR100733932B1 (ko) 2007-07-03
DK1208113T3 (da) 2009-08-31
CA2384184A1 (en) 2001-03-15
AU780077B2 (en) 2005-02-24
NO322108B1 (no) 2006-08-14
NO20021037D0 (no) 2002-03-01
AU7111300A (en) 2001-04-10
WO2001018025A3 (en) 2001-09-20
EP1208113A2 (en) 2002-05-29
CA2384184C (en) 2008-07-08
JP4837858B2 (ja) 2011-12-14

Similar Documents

Publication Publication Date Title
MXPA00008738A (es) 20-ceto-1 1b-arilesteroides y sus derivados teniendo propiedades agonistas o antagonistas hormonales.
CY1109451T1 (el) 17βητα-ακυλ-17αλφα-προπυνυλ-11βητα-(κυκλικα αμινο)αρυλ στεροειδη και παραγωγα αυτων που εχουν ιδιοτητες ορμονικου ανταγωνιστη
CY1106444T1 (el) 17b-νιτρο-11β-αρυλοστepοειδη και παραγωγα αυτων ως ορμονικοι αγωνιστες ή ανταγωνιστες
HUP0401643A2 (hu) Szubsztituált karbamid neuropeptid Y Y5 receptor antagonisták, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
DK1392714T3 (da) Steroider som agonister for FXR
HUP0103460A2 (hu) Vírusellenes hatású indolszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények
DE60135919D1 (de) Farnesyl transferase-hemmende 6-heterocyclylmethyl-chinolin und chinazol-derivate
BR9714358A (pt) Derivados de n- (arila/heteroarila) amino ácido,composições farmacêuticas compreendendo os mesmos, e métodos para a inibição de liberação de peptìdeo beta-amilóide e/ou sua sìntese por uso de tais compostos
NO20042811L (no) Substituerte henzoksazoler og analoger som estrogene midler
DE69840603D1 (de) Alpha-ketoamidhaltige multikatalytische protease inhibitoren
CY1108453T1 (el) Διαδικασια για την παρασκευη επλερενονης
BR0211972A (pt) Composição oftálmica
TR200002542T2 (tr) Meta-azasiklik amino benzoik asit bileşikleri ve bunların integrin antagonistleri olan türevleri
DK1097173T3 (da) Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
NO975975L (no) Vitronektinreseptor-antagonister, fremstilling samt anvendelse derav
AP1795A (en) Peptide deformylase inhibitors.
DE60120427D1 (de) Radicicol und monocillin und ihre analogen und ihre anwendungen
DK1082337T3 (da) 17-beta-amino- og hydroxylamino-11-beta-arylsteroider og deres derivater, som har agonistiske eller antagonistiske, hormonale egenskaber
SE9801494D0 (sv) Novel use
DK1135403T3 (da) 17beta-acyl-17alfa-propynyl-11beta-arylsteroider og deres derivater med agonistiske eller antagonistiske hormonale egenskaber
CY1105798T1 (el) Στepοειδη, η παρασκευη τους, φαρμακευτικες συνθεσεις απο αυτα και χρησεις των ενωσεων
ATE266029T1 (de) Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
HUP0402081A2 (hu) NK-2 antagonista hatású egyenes láncú bázisos vegyületek és ezeket tartalmazó gyógyszerészeti készítmények
CY1106201T1 (el) Αναλογα δισκοδepμολιδης και η φαρμακευτικη τους χρηση
ATE328595T1 (de) Carvedilolpolymorph

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees