HUP0301577A3 - Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use - Google Patents
Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their useInfo
- Publication number
- HUP0301577A3 HUP0301577A3 HU0301577A HUP0301577A HUP0301577A3 HU P0301577 A3 HUP0301577 A3 HU P0301577A3 HU 0301577 A HU0301577 A HU 0301577A HU P0301577 A HUP0301577 A HU P0301577A HU P0301577 A3 HUP0301577 A3 HU P0301577A3
- Authority
- HU
- Hungary
- Prior art keywords
- spiro
- pyrimidine
- pharmaceutical compositions
- compositions containing
- metalloproteinase inhibitors
- Prior art date
Links
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24338900P | 2000-10-26 | 2000-10-26 | |
PCT/IB2001/001986 WO2002034753A2 (en) | 2000-10-26 | 2001-10-23 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301577A2 HUP0301577A2 (hu) | 2003-11-28 |
HUP0301577A3 true HUP0301577A3 (en) | 2006-02-28 |
Family
ID=22918584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301577A HUP0301577A3 (en) | 2000-10-26 | 2001-10-23 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use |
Country Status (32)
Country | Link |
---|---|
EP (1) | EP1332146A2 (hr) |
JP (1) | JP2004518635A (hr) |
KR (1) | KR20040004412A (hr) |
CN (1) | CN1501937A (hr) |
AP (1) | AP2001002318A0 (hr) |
AR (1) | AR035069A1 (hr) |
AU (1) | AU2002210813A1 (hr) |
BG (1) | BG107653A (hr) |
BR (1) | BR0114913A (hr) |
CA (1) | CA2425283A1 (hr) |
CZ (1) | CZ20031083A3 (hr) |
EA (1) | EA005762B1 (hr) |
EC (1) | ECSP034567A (hr) |
EE (1) | EE200300196A (hr) |
GT (1) | GT200100213A (hr) |
HN (1) | HN2001000244A (hr) |
HR (1) | HRP20030332A2 (hr) |
HU (1) | HUP0301577A3 (hr) |
IL (1) | IL154948A0 (hr) |
IS (1) | IS6762A (hr) |
MA (1) | MA26957A1 (hr) |
MX (1) | MXPA03003735A (hr) |
NO (1) | NO20031853L (hr) |
OA (1) | OA12529A (hr) |
PA (1) | PA8531401A1 (hr) |
PE (1) | PE20020589A1 (hr) |
PL (1) | PL366201A1 (hr) |
SK (1) | SK4972003A3 (hr) |
SV (1) | SV2003000705A (hr) |
TN (1) | TNSN01149A1 (hr) |
WO (1) | WO2002034753A2 (hr) |
ZA (1) | ZA200302190B (hr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DOP2002000332A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
DOP2002000333A (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
BR0207865A (pt) | 2001-02-14 | 2004-03-23 | Warner Lambert Co | Benzotiadiazinas inibidores de metaloproteinases de matriz |
MXPA03004920A (es) | 2001-02-14 | 2003-09-05 | Warner Lambert Co | Pirimidinas inhibidoras de metaloproteinasas de matriz. |
PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
BR0213233A (pt) | 2001-10-12 | 2005-01-04 | Warner Lambert Co | Alcinos inibidores de metaloproteinase de matriz |
US6962922B2 (en) | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
WO2003091252A1 (en) * | 2002-04-25 | 2003-11-06 | Bristol-Myers Squibb Company | Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases |
AU2003219410A1 (en) * | 2002-04-26 | 2003-11-10 | Pfizer Products Inc. | Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors |
WO2003091258A1 (en) * | 2002-04-26 | 2003-11-06 | Pfizer Products Inc. | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
CA2497658A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Chromone derivatives as matrix metalloproteinase inhibitors |
MXPA05001786A (es) | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de azaisoquinolina como inhibidores de la metaloproteinasa de matriz. |
AU2003250466A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors |
PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
WO2004014923A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidinone fused bicyclic metalloproteinase inhibitors |
WO2004014375A2 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused bicyclic metalloproteinase inhibitors |
ATE359791T1 (de) | 2002-08-13 | 2007-05-15 | Warner Lambert Co | Pyrimidin-2,4-dion-derivate als matrix- metalloproteinase-hemmer |
WO2004014908A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Heterobicylcic metalloproteinase inhibitors |
MXPA05001603A (es) | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados monociclicos como inhibidores de metaloproteinasa de matriz. |
WO2004014909A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors |
US7208490B2 (en) | 2002-10-07 | 2007-04-24 | Pharmacia & Upjohn Company Llc | Tricyclic tetrahydroquinoline antibacterial agents |
GB0223249D0 (en) * | 2002-10-08 | 2002-11-13 | Amersham Plc | Improved imaging agents |
WO2004084903A1 (en) * | 2003-03-27 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis |
WO2004084902A1 (en) * | 2003-03-28 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment of chronic wounds |
FR2858232B1 (fr) * | 2003-07-29 | 2006-03-03 | Pierre Potier | Utilisation d'un derive de biguanide pour proteger la peau des radiations uvb |
MXPA06011030A (es) * | 2004-04-01 | 2007-03-21 | Hoffmann La Roche | Uso de una trioxopirimidina para el tratamiento y prevencion de enfermedades inflamatorias bronquiales. |
DOP2006000268A (es) | 2005-12-22 | 2007-07-31 | Pfizer Prod Inc | Agentes antibacterianos |
US8153166B2 (en) * | 2006-06-08 | 2012-04-10 | Chih-Hsiung Lin | Composition for prophylaxis or treatment of urinary system infection and method thereof |
CN102285934B (zh) * | 2009-01-08 | 2013-08-14 | 四川大学 | 螺环二烯酮衍生物及其制备方法和用途 |
LT2930176T (lt) * | 2012-12-10 | 2018-04-10 | Chugai Seiyaku Kabushiki Kaisha | Hidantoino dariniai |
KR101594506B1 (ko) * | 2014-03-20 | 2016-02-17 | 한국화학연구원 | 골 관련 질환 치료용 조성물 |
CA2949023C (en) | 2014-06-09 | 2021-10-12 | Hiroshi Noda | Hydantoin derivative-containing pharmaceutical composition |
WO2020113088A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
CN110092790B (zh) * | 2019-06-11 | 2020-07-24 | 东北农业大学 | 一种生物碱类化合物及其制备方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3714093A (en) * | 1970-05-19 | 1973-01-30 | American Home Prod | Spiro [heterocycloalkyl-2'(1'h)-quinazoline]-4'(3'h)-ones |
CA2294259A1 (en) * | 1997-06-21 | 1998-12-30 | Roche Diagnostics Gmbh | Barbituric acid derivatives with antimetastatic and antitumor activity |
US6265578B1 (en) * | 1999-02-12 | 2001-07-24 | Hoffmann-La Roche Inc. | Pyrimidine-2,4,6-triones |
HN2000000137A (es) * | 1999-08-12 | 2001-02-02 | Pfizer Prod Inc | Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas |
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2001
- 2001-10-23 SK SK497-2003A patent/SK4972003A3/sk unknown
- 2001-10-23 AU AU2002210813A patent/AU2002210813A1/en not_active Abandoned
- 2001-10-23 EA EA200300306A patent/EA005762B1/ru not_active IP Right Cessation
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- 2001-10-23 WO PCT/IB2001/001986 patent/WO2002034753A2/en not_active Application Discontinuation
- 2001-10-23 KR KR10-2003-7005753A patent/KR20040004412A/ko not_active Application Discontinuation
- 2001-10-23 EE EEP200300196A patent/EE200300196A/xx unknown
- 2001-10-23 CN CNA018179231A patent/CN1501937A/zh active Pending
- 2001-10-23 PL PL01366201A patent/PL366201A1/xx not_active Application Discontinuation
- 2001-10-23 EP EP01978721A patent/EP1332146A2/en not_active Withdrawn
- 2001-10-23 CA CA002425283A patent/CA2425283A1/en not_active Abandoned
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- 2001-10-23 AP APAP/P/2001/002318A patent/AP2001002318A0/en unknown
- 2001-10-23 HU HU0301577A patent/HUP0301577A3/hu unknown
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- 2001-10-23 JP JP2002537743A patent/JP2004518635A/ja not_active Withdrawn
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