HUP0301576A2 - A Neutrofilek IL-8 által indukált kemotaxisának gátlására alkalmazható amidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

A Neutrofilek IL-8 által indukált kemotaxisának gátlására alkalmazható amidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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HUP0301576A2
HUP0301576A2 HU0301576A HUP0301576A HUP0301576A2 HU P0301576 A2 HUP0301576 A2 HU P0301576A2 HU 0301576 A HU0301576 A HU 0301576A HU P0301576 A HUP0301576 A HU P0301576A HU P0301576 A2 HUP0301576 A2 HU P0301576A2
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group
general formula
imidazolyl
formula
alkyl
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HU0301576A
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Marcello Allegretti
Riccardo Bertini
Gianfranco Caselli
Maria Candida Cesta
Bizzarri Cinzia
Francesco Colotta
Carmelo Gandolfi
Vilma Sabbatini
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Dompé S.p.A.
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Publication of HUP0301576A3 publication Critical patent/HUP0301576A3/hu
Publication of HU229447B1 publication Critical patent/HU229447B1/hu

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Abstract

A találmány tárgya az (I) általános képletű 2-aril-propionamid- (R)-enantiomerek és ezek gyógyászatilag elfogadható sói a neutrofilekinterleukin-8 által indukált kemotaxisának gátlására valóalkalmazásra. Az (I) általános képletben Aril jelentése adott esetbenhelyettesített arilcsoport; R jelentése hidrogénatom vagy alkil-, allil-, propargilcsoport vagy-CH2COOH vagy -(CH2)2-COOH képletű csoport; R' jelentése - aminosavmaradék, amely egy vagy több karboxicsoporttal helyettesített alkil-,alkenil- vagy cikloalkil vagy fenilalkil-csoportot tartalmaz; -aminosav maradék, amely egy vagy több karboxicsoporttal és az oxigén-és kénatom közül választott heteroatommal helyettesített alkil-,alkenil-, cikloalkil- vagy fenilalkil-csoportot tartalmaz; - -CH2-CH2X- (CH2-CH2O)nR általános képletű csoport, ahol R jelentése afenti; n értéke 0 és 5 közötti egész szám, míg X jelentése oxigén vagykén; - (R) vagy (S)-CH(CH3)-CH2-O-CH2-CH2-OH képletű csoport, - -ORáltalános képletű csoport, ahol R jelentése a fenti; - (III) általánosképletű csoport, ahol ahol F jelentése 2-(1-metil-pirrolidil), 2-piridil, 4-piridil, 1-imidazolil, 4-imidazolil, 1-metil-4-imidazolil,1-metil-5-imidazolil vagy -NRaRb általános képletű csoport, ahol Ra ésRb jelentése egymással azonos vagy különböző, és lehet 1-6 szénatomosalkil- vagy -(CH2)m-OH általános képletű hidroxialkilcsoport, ahol mértéke 2 vagy 3, vagy Ra és Rb a nitrogénatommal együtt, amelyhezkapcsolódnak, egy 3-7 tagú (IV) általános képletű csoportot alkot,ahol Y jelentése egyes kötés, -CH2-, O, S vagy NRc általános képletűcsoport, ahol Rc jelentése hidrogénatom, alkilcsoport, -(CH2)mOHáltalános képletű hidroxialkilcsoport és/vagy egy -(CH2)m'Ar'általános képletű csoport, ahol Ar' jelentése aril-, heteroaril-,cikloalifás és/vagy heterocikloalifás csoport, m' értéke 0-tól 3-igterjedő egész szám és p és q jelentése egymástól függetlenül 1-től 3-ig terjedő egész szám; heteroarilcsoport, amelyet a következőcsoportok közül választanak: 2-piridil- vagy 4-piridil-, 2-pirimidinil- vagy 4-pirimidinil-, 2-pirazinil-, 5-metil-2-pirazinil;3-1,2,4-tiazinil; 3-1,2,4-tiazolil; 3-1-benzil-1,2,4-tiazolil-, 2-1,3-tiazolidinil-, 2-1,3-tiazolil-, 1,3-oxazolil-, 3-izoxazolil-, 4-dihidro-3-oxo-izoxazolil-, 5-metil-izoxazol-4-il, 2-imidazolil-, 4-imidazolil-5-karboxamid és 2-imidazolil-4,5-dikarbonitril-, 5-indanil-, 5-indazolil-, 7-aza-indol-3-il-, 2- vagy 3- vagy 4-kinolinilcsoport. A találmány kiterjed a vegyületek előállítására ésezeket tartalmazó gyógyszerkészítményekre is. Ó
HU0301576A 2000-02-11 2001-02-06 Amides useful in the inhibition of il-8-induced chemotaxis of neutrophils HU229447B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000227A IT1317826B1 (it) 2000-02-11 2000-02-11 Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
PCT/EP2001/001285 WO2001058852A2 (en) 2000-02-11 2001-02-06 (r)-2-aryl-propionamides, useful in the inhibition of il-8-induced chemiotaxis of neutrophils

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HUP0301576A2 true HUP0301576A2 (hu) 2003-11-28
HUP0301576A3 HUP0301576A3 (en) 2004-10-28
HU229447B1 HU229447B1 (en) 2013-12-30

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IT1318466B1 (it) * 2000-04-14 2003-08-25 Dompe Spa Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria.
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
ITMI20010395A1 (it) 2001-02-27 2002-08-27 Dompe Spa Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate
ITMI20012025A1 (it) * 2001-09-28 2003-03-28 Dompe Spa Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
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