HUP0203551A2 - Eljárások 2-(2-hidroxi-fenil)-2-(alkoximino)-N-metil-acetamid-származékok előállítására és új intermedierek - Google Patents

Eljárások 2-(2-hidroxi-fenil)-2-(alkoximino)-N-metil-acetamid-származékok előállítására és új intermedierek

Info

Publication number
HUP0203551A2
HUP0203551A2 HU0203551A HUP0203551A HUP0203551A2 HU P0203551 A2 HUP0203551 A2 HU P0203551A2 HU 0203551 A HU0203551 A HU 0203551A HU P0203551 A HUP0203551 A HU P0203551A HU P0203551 A2 HUP0203551 A2 HU P0203551A2
Authority
HU
Hungary
Prior art keywords
formula
optionally
hydroxyphenyl
general formula
diluent
Prior art date
Application number
HU0203551A
Other languages
English (en)
Inventor
Bernd Gallenkamp
Herbert Gayer
Walter Hübsch
Reinhard Lantzsch
Lubbertus Mulder
Thorsten Müh
Holger Weintritt
Original Assignee
Bayer Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag. filed Critical Bayer Ag.
Publication of HUP0203551A2 publication Critical patent/HUP0203551A2/hu
Publication of HUP0203551A3 publication Critical patent/HUP0203551A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/12—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reactions not involving the formation of oxyimino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány (I) általános képletű 2-(2-hidroxi-fenil)-2-alkoximino)-N-metilacetamid-származékok - e képletben R jelentése szubsztituált vagyszubsztituálatlan alkilcsoport - előállítására alkalmas több újeljárásra, új (II), (IV) és (VI) képletű, közbenső termékekre,valamint e közbenső termékek előállítására alkalmas eljárásravonatkozik. A találmány értelmében a) a (II) képletű vegyületet (III)általános képletű alkilezőszerrel, amelynek képletében R jelentése afenti, és X jelentése halogénatom, -O-CO-O-R, -O-SO2-R1 vagy -O-SO2-O-R képletű csoport, ahol R jelentése a fenti és R1 jelentésealkilcsoport vagy adott esetben alkilcsoporttal szubsztituáltfenilcsoport, adott esetben hígítószer jelenlétében és adott esetbenfázistranszfer-katalizátor jelenlétében reagáltatják, vagy b) a (IV)képletű vegyületet (V) általános képletű alkoxiaminnal vagysavaddíciós komplexével adott esetben hígítószer jelenlétében és adottesetben pufferközeg jelenlétében reagáltatják, vagy c) a (VI) képletűvegyületet (V) általános képletű alkoxiaminnal vagy savaddícióskomplexével adott esetben hígítószer jelenlétében és adott esetbenpufferközeg jelenlétében reagáltatják. Ó
HU0203551A 1999-11-26 2000-11-14 Methods for producing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-n-methylacetamide derivatives and new intermediates HUP0203551A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19956920A DE19956920A1 (de) 1999-11-26 1999-11-26 Verfahren zur Herstellung von 2-(2-Hydrodyphenyl)-2-(alkoxyimino)-N-methyl-acetamid-Derivaten
PCT/EP2000/011225 WO2001038294A2 (de) 1999-11-26 2000-11-14 Verfahren zur herstellung von 2-(2-hydroxyphenyl)-2-(alkoxyimino)-n-methylacetamid-derivaten

Publications (2)

Publication Number Publication Date
HUP0203551A2 true HUP0203551A2 (hu) 2003-02-28
HUP0203551A3 HUP0203551A3 (en) 2003-04-28

Family

ID=7930411

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203551A HUP0203551A3 (en) 1999-11-26 2000-11-14 Methods for producing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-n-methylacetamide derivatives and new intermediates

Country Status (13)

Country Link
US (2) US6700017B1 (hu)
EP (1) EP1235790A2 (hu)
JP (1) JP2003514890A (hu)
KR (1) KR20020051926A (hu)
CN (1) CN1399628A (hu)
AU (1) AU1857101A (hu)
BR (1) BR0015813A (hu)
DE (1) DE19956920A1 (hu)
HU (1) HUP0203551A3 (hu)
IL (1) IL149288A0 (hu)
MX (1) MXPA02005184A (hu)
WO (1) WO2001038294A2 (hu)
ZA (1) ZA200203079B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10138575A1 (de) * 2001-08-06 2003-02-20 Bayer Cropscience Ag Verfahren zur Herstellung von 2-(Hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamid-Derivaten
CN105669486B (zh) * 2015-12-30 2017-12-05 嘉兴学院 一种n‑酰基‑2,6‑二芳基苄胺衍生物的制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE145891T1 (de) 1989-05-17 1996-12-15 Shionogi & Co Verfahren zur herstellung von alkoxyiminoacetamid-derivaten und ein zwischenproduckt dafür
JPH0725727B2 (ja) 1990-07-26 1995-03-22 塩野義製薬株式会社 メトキシイミノアセトアミド化合物の製造法
JP3121061B2 (ja) * 1991-10-04 2000-12-25 塩野義製薬株式会社 アルコキシイミノアセトアミド類製造用中間体の製造法およびそれに用いる中間体
DE4318917A1 (de) 1993-06-07 1994-12-08 Bayer Ag 2-Oximino-2-phenyl-acetamide
GB9404375D0 (en) 1994-03-07 1994-04-20 Zeneca Ltd Fungicides
US5665880A (en) 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes

Also Published As

Publication number Publication date
KR20020051926A (ko) 2002-06-29
WO2001038294A2 (de) 2001-05-31
CN1399628A (zh) 2003-02-26
US6700017B1 (en) 2004-03-02
MXPA02005184A (es) 2003-01-28
IL149288A0 (en) 2002-11-10
ZA200203079B (en) 2003-06-25
BR0015813A (pt) 2002-07-16
US20040147782A1 (en) 2004-07-29
WO2001038294A3 (de) 2001-10-18
AU1857101A (en) 2001-06-04
US6831197B2 (en) 2004-12-14
JP2003514890A (ja) 2003-04-22
DE19956920A1 (de) 2001-05-31
EP1235790A2 (de) 2002-09-04
HUP0203551A3 (en) 2003-04-28

Similar Documents

Publication Publication Date Title
GB0229583D0 (en) A process for preparing duloxetine and intermediates for use therein
NO20062936L (no) Fremgangsmate for fremstilling av N-alkyl-2(hydroksy-4-benzoyl)-3-benzofuraner og dets mellomprodukter derav
ATE402185T1 (de) Verfahren für fluorcytidinderivate
HUP0401486A2 (hu) Eljárás piridinvegyületek előállítására
HUP0300856A2 (hu) Eljárás szubsztituált fenil-acetonitrilek elżállítására
PL360499A1 (en) Method of manufacture of donepezyl
HUP0203551A2 (hu) Eljárások 2-(2-hidroxi-fenil)-2-(alkoximino)-N-metil-acetamid-származékok előállítására és új intermedierek
PT1102765E (pt) Processo para a sintese de derivados de (1h)-benzo¬c|quinolizin-3-onas
ATE496907T1 (de) Verfahren zur herstellung von cilostazol
WO2007039117A3 (en) A process for the preparation of sartan derivatives and intermediates useful in such process
NO20053712L (no) Fremgangsmate for fremstilling av substituerte imidazolderivater og mellomprodukter anvendt i fremgangsmaten
EE05136B1 (et) Asendatud imidasopridiinhendite valmistamise meetod
IL182557A0 (en) Process for the preparation of phenyl 2-pyrimidinyl ketones and their novel intermediates
HUP0303686A2 (hu) Eljárás Delta1-pirrolin-származékok előállítására és az új intermedierek
HUP0301141A2 (hu) Eljárás trisz-oximszármazékok előállítására
FR2854402B1 (fr) Nouveau procede et intermediaires de preparation de composes 19-nor-steroides
ATE346845T1 (de) Ein verfahren zur herstellung substituierter alkylamin-derivate
GB9906328D0 (en) 2-Substituted RNA preparation
HUP0401458A2 (hu) Eljárás 4-metilamino-4-fenilpiperidin előállítására
SE0002268D0 (sv) Novel beta-hydroxymides
EP1219610A4 (en) PROCESS FOR THE PREPARATION OF OXAZOLE DERIVATIVES
WO2002076940A3 (en) Process for preparing arylpiperidine carbinol intermediates and derivatives
HUP0300842A2 (hu) Eljárás rovarirtó hatású vegyületek előállítására és az eljárás új köztitermékei
HUP0101063A2 (hu) Eljárás alkoxi-triazolinon-származékok előállítására
FR2788276B1 (fr) NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice)

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees