HUP0303686A2 - Eljárás Delta1-pirrolin-származékok előállítására és az új intermedierek - Google Patents
Eljárás Delta1-pirrolin-származékok előállítására és az új intermedierekInfo
- Publication number
- HUP0303686A2 HUP0303686A2 HU0303686A HUP0303686A HUP0303686A2 HU P0303686 A2 HUP0303686 A2 HU P0303686A2 HU 0303686 A HU0303686 A HU 0303686A HU P0303686 A HUP0303686 A HU P0303686A HU P0303686 A2 HUP0303686 A2 HU P0303686A2
- Authority
- HU
- Hungary
- Prior art keywords
- pyrrolines
- delta1
- producing
- novel intermediates
- formula
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
Abstract
A találmány szerinti eljárással az (I) általános képletű 2,5-bisz-aril-D1-pirrolin-származékokat úgy állítják elő, hogy (II) általánosképletű amidokat N-dezacilező szerrel reagáltatnak hígítószerjelenlétében. Az (I) és (II) általános képletben a szubsztituensekjelentése az alábbi Ar1 és Ar2 jelentése szubsztituált fenilcsoport;R9 jelentése alkil-, halogénalkil-, adott esetben szubsztituált aril-vagy aralkilcsoport. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10047109A DE10047109A1 (de) | 2000-09-22 | 2000-09-22 | Verfahren zur Herstellung von DELTA·1·-Pyrrolinen |
PCT/EP2001/010423 WO2002024642A1 (de) | 2000-09-22 | 2001-09-10 | Verfahren zur herstellung von δ1-pyrrolinen |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0303686A2 true HUP0303686A2 (hu) | 2004-03-29 |
Family
ID=7657310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0303686A HUP0303686A2 (hu) | 2000-09-22 | 2001-09-10 | Eljárás Delta1-pirrolin-származékok előállítására és az új intermedierek |
Country Status (12)
Country | Link |
---|---|
US (1) | US20040054194A1 (hu) |
EP (1) | EP1322606A1 (hu) |
JP (1) | JP2004509165A (hu) |
KR (1) | KR20030034169A (hu) |
CN (1) | CN1466571A (hu) |
AU (1) | AU2002212224A1 (hu) |
BR (1) | BR0114060A (hu) |
DE (1) | DE10047109A1 (hu) |
HU (1) | HUP0303686A2 (hu) |
IL (1) | IL154825A0 (hu) |
MX (1) | MXPA03002500A (hu) |
WO (1) | WO2002024642A1 (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10047110A1 (de) * | 2000-09-22 | 2002-04-18 | Bayer Ag | Optisch aktive 2,5-Bisaryl-DELTA·1·-Pyrroline |
DE10204115A1 (de) * | 2002-02-01 | 2003-08-07 | Bayer Cropscience Ag | DELTA·1·-Pyrroline |
US7504401B2 (en) | 2003-08-29 | 2009-03-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
CN103450077B (zh) | 2007-06-08 | 2016-07-06 | 满康德股份有限公司 | IRE-1α抑制剂 |
KR100968016B1 (ko) * | 2008-02-22 | 2010-07-07 | 김선도 | 헬스 자전거 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19648011A1 (de) * | 1996-11-20 | 1998-05-28 | Bayer Ag | Cyclische Imine |
DE19822247A1 (de) * | 1998-05-18 | 1999-11-25 | Bayer Ag | 2-(2-Chlorphenyl)-3,4-dihydro-2H-pyrrol-Derivate |
DE19822245A1 (de) * | 1998-05-18 | 1999-11-25 | Bayer Ag | 2-(2-Methylphenyl)-3,4-dihydro-2H-pyrrol- Derivate |
-
2000
- 2000-09-22 DE DE10047109A patent/DE10047109A1/de not_active Withdrawn
-
2001
- 2001-09-10 BR BR0114060-4A patent/BR0114060A/pt not_active Application Discontinuation
- 2001-09-10 MX MXPA03002500A patent/MXPA03002500A/es unknown
- 2001-09-10 US US10/380,599 patent/US20040054194A1/en not_active Abandoned
- 2001-09-10 JP JP2002529055A patent/JP2004509165A/ja active Pending
- 2001-09-10 CN CNA018161529A patent/CN1466571A/zh active Pending
- 2001-09-10 IL IL15482501A patent/IL154825A0/xx unknown
- 2001-09-10 HU HU0303686A patent/HUP0303686A2/hu unknown
- 2001-09-10 EP EP01980363A patent/EP1322606A1/de not_active Withdrawn
- 2001-09-10 KR KR10-2003-7003258A patent/KR20030034169A/ko not_active Application Discontinuation
- 2001-09-10 AU AU2002212224A patent/AU2002212224A1/en not_active Abandoned
- 2001-09-10 WO PCT/EP2001/010423 patent/WO2002024642A1/de not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20040054194A1 (en) | 2004-03-18 |
WO2002024642A8 (de) | 2003-05-01 |
EP1322606A1 (de) | 2003-07-02 |
KR20030034169A (ko) | 2003-05-01 |
IL154825A0 (en) | 2003-10-31 |
WO2002024642A1 (de) | 2002-03-28 |
DE10047109A1 (de) | 2002-04-11 |
AU2002212224A1 (en) | 2002-04-02 |
JP2004509165A (ja) | 2004-03-25 |
MXPA03002500A (es) | 2004-09-10 |
CN1466571A (zh) | 2004-01-07 |
BR0114060A (pt) | 2003-07-22 |
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