HUP0203473A2 - 6,9-Bisz-[(2-aminoetil)amino]benzo[g]izokinolin-5,10-dion-dimaleát liposzómás készítmény - Google Patents
6,9-Bisz-[(2-aminoetil)amino]benzo[g]izokinolin-5,10-dion-dimaleát liposzómás készítményInfo
- Publication number
- HUP0203473A2 HUP0203473A2 HU0203473A HUP0203473A HUP0203473A2 HU P0203473 A2 HUP0203473 A2 HU P0203473A2 HU 0203473 A HU0203473 A HU 0203473A HU P0203473 A HUP0203473 A HU P0203473A HU P0203473 A2 HUP0203473 A2 HU P0203473A2
- Authority
- HU
- Hungary
- Prior art keywords
- isoquinoline
- aminoethyl
- benzo
- bis
- amino
- Prior art date
Links
- SVAGFBGXEWPNJC-SPIKMXEPSA-N 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione;(z)-but-2-enedioic acid Chemical group OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.O=C1C2=CN=CC=C2C(=O)C2=C1C(NCCN)=CC=C2NCCN SVAGFBGXEWPNJC-SPIKMXEPSA-N 0.000 title abstract 3
- 239000002502 liposome Substances 0.000 title abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- 235000012000 cholesterol Nutrition 0.000 abstract 2
- 150000003904 phospholipids Chemical class 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- -1 compound 6,9-Bis-[(2-aminoethyl)amino]-benzo[g]isoquinoline-5,10-dione-dimaleate Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány az (1) képletű 6,9-Bisz-[(2-aminoetil)-amino]-benzo[g]izokinolin-5,10-dion-dimaleát (BBR 2778) vegyület liposzómásgyógyászati készítményére vonatkozik, amelyben a liposzómákfoszfatidilkolint, koleszterint és BBR 2778 vegyületet tartalmaznak,ahol a koleszterin/foszfolipid tömegarány 1:2 és 1:7 közötti, és a BBR2778/foszfolipid tömegarány 1:4 és 1:25 közötti. A találmány tárgyatovábbá a liposzómás készítmény alkalmazása daganatellenes gyógyszerelőállítására. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI002219A IT1315253B1 (it) | 1999-10-22 | 1999-10-22 | Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato |
PCT/EP2000/010303 WO2001028521A2 (en) | 1999-10-22 | 2000-10-19 | Liposome formulation of 6,9-bis-[(2-aminoethyl)-amino]benzo[g]isoquinoline-5,10-dione dimaleate |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203473A2 true HUP0203473A2 (hu) | 2003-02-28 |
HUP0203473A3 HUP0203473A3 (en) | 2003-12-29 |
Family
ID=11383836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203473A HUP0203473A3 (en) | 1999-10-22 | 2000-10-19 | Liposome composition of 6,9-bis-[(2-aminoethyl)-amino]benzo[g]isoquinoline-5,10-dione dimaleate |
Country Status (23)
Country | Link |
---|---|
US (1) | US7449197B2 (hu) |
EP (1) | EP1221940B1 (hu) |
JP (1) | JP2003512313A (hu) |
KR (1) | KR20020063880A (hu) |
CN (1) | CN1164261C (hu) |
AT (1) | ATE335468T1 (hu) |
AU (1) | AU772339B2 (hu) |
BR (1) | BR0014881A (hu) |
CA (1) | CA2386143A1 (hu) |
CZ (1) | CZ20021388A3 (hu) |
DE (1) | DE60029979T2 (hu) |
EA (1) | EA004477B1 (hu) |
ES (1) | ES2269200T3 (hu) |
HU (1) | HUP0203473A3 (hu) |
IL (2) | IL149212A0 (hu) |
IT (1) | IT1315253B1 (hu) |
MX (1) | MXPA02003939A (hu) |
NO (1) | NO20021867L (hu) |
NZ (1) | NZ518005A (hu) |
PL (1) | PL197412B1 (hu) |
SK (1) | SK284247B6 (hu) |
WO (1) | WO2001028521A2 (hu) |
ZA (1) | ZA200203128B (hu) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU769569B2 (en) * | 1998-12-18 | 2004-01-29 | Alza Corporation | Method of administering a compound to multi-drug resistant cells |
ITMI20021040A1 (it) * | 2002-05-16 | 2003-11-17 | Novuspharma Spa | Composizioni farmaceutiche iniettabili di un derivato antracenedionico ad attivita' antitumorale |
CN1305881C (zh) * | 2004-08-13 | 2007-03-21 | 河南工业大学 | 磷脂酰胆碱的制备方法 |
CN103479578B (zh) * | 2012-06-14 | 2016-08-03 | 沈阳药科大学 | 一种马来酸匹杉琼的脂质体制剂及其制备工艺 |
CN105596295B (zh) * | 2016-01-25 | 2018-03-16 | 北京博恩特药业有限公司 | 马来酸匹杉琼脂质体及其制备方法 |
CN105997896B (zh) * | 2016-05-28 | 2019-07-05 | 长沙秋点兵信息科技有限公司 | 治疗非霍奇金淋巴瘤的注射用冻干粉及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4797285A (en) * | 1985-12-06 | 1989-01-10 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | Lipsome/anthraquinone drug composition and method |
JPS6442418A (en) * | 1985-12-06 | 1989-02-14 | Yissum Res Dev Co | Liposome/anthraquinone drug composition and therapy therewith |
MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
ES2072223B1 (es) * | 1993-11-25 | 1996-03-16 | Lipotec Sa | Liposomas encapsulando doxorubicina. |
WO1995024201A1 (fr) * | 1994-03-11 | 1995-09-14 | Yoshitomi Pharmaceutical Industries, Ltd. | Preparation de liposomes |
US5506232A (en) * | 1994-03-28 | 1996-04-09 | Boehringer Mannheim Italia S.P.A. | 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt |
US5587382A (en) * | 1994-03-28 | 1996-12-24 | Boehringer Mannheim Italia, Spa | 6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione dimaleate; an aza-anthracenedione with reduced cardiotoxicity |
JP2001514209A (ja) * | 1997-09-04 | 2001-09-11 | バイオゾーン ラボラトリーズ,インコーポレイテッド | 経口リポソーム送達系 |
-
1999
- 1999-10-22 IT IT1999MI002219A patent/IT1315253B1/it active
-
2000
- 2000-10-19 EA EA200200389A patent/EA004477B1/ru not_active IP Right Cessation
- 2000-10-19 HU HU0203473A patent/HUP0203473A3/hu unknown
- 2000-10-19 CN CNB008146004A patent/CN1164261C/zh not_active Expired - Fee Related
- 2000-10-19 KR KR1020027004996A patent/KR20020063880A/ko not_active Application Discontinuation
- 2000-10-19 CZ CZ20021388A patent/CZ20021388A3/cs unknown
- 2000-10-19 AT AT00977418T patent/ATE335468T1/de not_active IP Right Cessation
- 2000-10-19 IL IL14921200A patent/IL149212A0/xx active IP Right Grant
- 2000-10-19 JP JP2001531351A patent/JP2003512313A/ja active Pending
- 2000-10-19 PL PL354610A patent/PL197412B1/pl not_active IP Right Cessation
- 2000-10-19 SK SK538-2002A patent/SK284247B6/sk not_active IP Right Cessation
- 2000-10-19 MX MXPA02003939A patent/MXPA02003939A/es active IP Right Grant
- 2000-10-19 NZ NZ518005A patent/NZ518005A/en unknown
- 2000-10-19 AU AU15146/01A patent/AU772339B2/en not_active Ceased
- 2000-10-19 BR BR0014881-4A patent/BR0014881A/pt not_active Application Discontinuation
- 2000-10-19 EP EP00977418A patent/EP1221940B1/en not_active Expired - Lifetime
- 2000-10-19 ES ES00977418T patent/ES2269200T3/es not_active Expired - Lifetime
- 2000-10-19 DE DE60029979T patent/DE60029979T2/de not_active Expired - Fee Related
- 2000-10-19 CA CA002386143A patent/CA2386143A1/en not_active Abandoned
- 2000-10-19 WO PCT/EP2000/010303 patent/WO2001028521A2/en active IP Right Grant
-
2002
- 2002-04-18 IL IL149212A patent/IL149212A/en not_active IP Right Cessation
- 2002-04-19 NO NO20021867A patent/NO20021867L/no not_active Application Discontinuation
- 2002-04-19 ZA ZA200203128A patent/ZA200203128B/en unknown
-
2005
- 2005-11-21 US US11/283,941 patent/US7449197B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |