JPS6442418A - Liposome/anthraquinone drug composition and therapy therewith - Google Patents

Liposome/anthraquinone drug composition and therapy therewith

Info

Publication number
JPS6442418A
JPS6442418A JP19514787A JP19514787A JPS6442418A JP S6442418 A JPS6442418 A JP S6442418A JP 19514787 A JP19514787 A JP 19514787A JP 19514787 A JP19514787 A JP 19514787A JP S6442418 A JPS6442418 A JP S6442418A
Authority
JP
Japan
Prior art keywords
liposome
anthraquinone
doxorubicin
composition
lipid bilayer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP19514787A
Other languages
Japanese (ja)
Inventor
Barenhorutsu Ietsukezukeru
Giyabizon Arubaato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hadassah Medical Organization
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Hadassah Medical Organization
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/806,084 external-priority patent/US4797285A/en
Application filed by Hadassah Medical Organization, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Hadassah Medical Organization
Publication of JPS6442418A publication Critical patent/JPS6442418A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To obtain a medical composition reduced in peroxylipids and free radial injuries by introducing a lipophilic free radical scavenger into a lipid bilayer part of a liposome and including a trihydroxamic chelating agent in the composition. CONSTITUTION: This composition comprises a liposome containing at least 0.1mol%, preferably 0.2-2mol% lipophilic free radical scavenger (e.g. α-tocopherol) introduced into a lipid bilayer part, an anthraquinone medicine having a quinone and a hydroquinone functional part in the adjacent anthraquinone ring (e.g. an anthracycline glycoside-based antibiotic agent such as doxorubicin or daunorubicin) and a trihydroxamic acid chelating agent present as a ferric ion in an excessive molar amount such as ferrioxamine. The size is mainly within the range of 0.05-0.25μm. An aqueous suspension containing at least 2.5mol% doxorubicin or its analog is administered to treat primary or secondary tumor of the liver.
JP19514787A 1985-12-06 1987-08-04 Liposome/anthraquinone drug composition and therapy therewith Pending JPS6442418A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/806,084 US4797285A (en) 1985-12-06 1985-12-06 Lipsome/anthraquinone drug composition and method

Publications (1)

Publication Number Publication Date
JPS6442418A true JPS6442418A (en) 1989-02-14

Family

ID=25193277

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19514787A Pending JPS6442418A (en) 1985-12-06 1987-08-04 Liposome/anthraquinone drug composition and therapy therewith

Country Status (1)

Country Link
JP (1) JPS6442418A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583058A (en) * 1992-09-17 1996-12-10 Mitsubishi Denki Kabushiki Kaisha Infrared detection element array and method for fabricating the same
JP2003512313A (en) * 1999-10-22 2003-04-02 ノブスファルマ ソチエタ ペル アツィオニ Liposomal preparation of 6,9-bis-[(2-aminoethyl) -amino] benzo [g] isoquinoline-5,10-dionedimaleate
JP2005513104A (en) * 2001-12-06 2005-05-12 イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム Tempamine compositions and methods of use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583058A (en) * 1992-09-17 1996-12-10 Mitsubishi Denki Kabushiki Kaisha Infrared detection element array and method for fabricating the same
JP2003512313A (en) * 1999-10-22 2003-04-02 ノブスファルマ ソチエタ ペル アツィオニ Liposomal preparation of 6,9-bis-[(2-aminoethyl) -amino] benzo [g] isoquinoline-5,10-dionedimaleate
JP2005513104A (en) * 2001-12-06 2005-05-12 イッサム リサーチ ディベロプメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム Tempamine compositions and methods of use

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