HUP0202650A2 - Fibrinolitikusan aktív polipeptid - Google Patents

Fibrinolitikusan aktív polipeptid

Info

Publication number
HUP0202650A2
HUP0202650A2 HU0202650A HUP0202650A HUP0202650A2 HU P0202650 A2 HUP0202650 A2 HU P0202650A2 HU 0202650 A HU0202650 A HU 0202650A HU P0202650 A HUP0202650 A HU P0202650A HU P0202650 A2 HUP0202650 A2 HU P0202650A2
Authority
HU
Hungary
Prior art keywords
active polypeptide
fibrinolytically active
polypeptide
subject
fibrinolytically
Prior art date
Application number
HU0202650A
Other languages
English (en)
Inventor
Thomas Charles Boone
Huimin Li
Michael Benjamin Mann
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of HUP0202650A2 publication Critical patent/HUP0202650A2/hu
Publication of HUP0202650A3 publication Critical patent/HUP0202650A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány tárgya fibrinolitikusan aktív metalloproteináz polipeptid(<új, hatékony trombolitikum<), ami jól használható in vivo vérrögöklizáltatására, valamint a találmány tárgyát képezik a polipeptidrekombináns expresszióval való előállításához használt módszerek ésanyagok. Ó
HU0202650A 1999-10-01 2000-09-29 Fibrinolytically active polypeptide HUP0202650A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/411,329 US6261820B1 (en) 1999-10-01 1999-10-01 Fibronolytically active polypeptide
PCT/US2000/027029 WO2001025445A1 (en) 1999-10-01 2000-09-29 Fibrinolytically active polypeptide

Publications (2)

Publication Number Publication Date
HUP0202650A2 true HUP0202650A2 (hu) 2002-12-28
HUP0202650A3 HUP0202650A3 (en) 2005-01-28

Family

ID=23628486

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202650A HUP0202650A3 (en) 1999-10-01 2000-09-29 Fibrinolytically active polypeptide

Country Status (29)

Country Link
US (4) US6261820B1 (hu)
EP (2) EP1605049A3 (hu)
JP (1) JP2003511034A (hu)
KR (2) KR100711312B1 (hu)
CN (2) CN100357430C (hu)
AT (1) ATE292180T1 (hu)
AU (1) AU767827B2 (hu)
BG (1) BG106577A (hu)
BR (1) BR0014414A (hu)
CA (1) CA2386185A1 (hu)
CZ (1) CZ298502B6 (hu)
DE (1) DE60019147T2 (hu)
DK (1) DK1224298T3 (hu)
EA (2) EA006487B1 (hu)
ES (1) ES2240167T3 (hu)
HK (1) HK1049351B (hu)
HU (1) HUP0202650A3 (hu)
IL (1) IL148787A0 (hu)
MX (1) MXPA02003126A (hu)
NO (1) NO20021501L (hu)
NZ (1) NZ517951A (hu)
PL (1) PL355017A1 (hu)
PT (1) PT1224298E (hu)
RS (1) RS20060033A (hu)
SG (1) SG127720A1 (hu)
SK (1) SK4232002A3 (hu)
WO (1) WO2001025445A1 (hu)
YU (2) YU59604A (hu)
ZA (1) ZA200202206B (hu)

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US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US7033776B2 (en) * 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
US6523647B2 (en) * 2001-05-21 2003-02-25 Hydro Mobile Inc. Elevating platform assembly
CN1326496C (zh) * 2002-02-11 2007-07-18 黄金－T技术股份有限公司 预防血栓形成的装置
US7016409B2 (en) * 2003-11-12 2006-03-21 Sony Corporation Apparatus and method for use in providing dynamic bit rate encoding
ES2239532B1 (es) * 2004-02-06 2006-11-01 Proyecto De Biomedicina Cima S.L. Metodo para evaluar el riesgo y la predisposicion a desarrollar una patologia relacionada con la presencia de autoanticuerpos frente a epcr.
US20070141625A1 (en) * 2005-02-03 2007-06-21 Santos Jose H Method for assessing risk of and predisposition to development of a pathology related to the presence of anti-epcr autoantibodies
US20070225749A1 (en) 2006-02-03 2007-09-27 Martin Brian B Methods and devices for restoring blood flow within blocked vasculature
EP2403583B1 (en) 2009-03-06 2016-10-19 Lazarus Effect, Inc. Retrieval systems
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
EP4105337A1 (en) 2014-09-09 2022-12-21 The Broad Institute, Inc. A droplet-based method and apparatus for composite single-cell nucleic acid analysis
CN107405470A (zh) 2015-02-11 2017-11-28 柯惠有限合伙公司 带可扩张尖端的医疗装置和方法
CN107614700A (zh) 2015-03-11 2018-01-19 布罗德研究所有限公司 基因型和表型偶联
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
WO2017075265A1 (en) 2015-10-28 2017-05-04 The Broad Institute, Inc. Multiplex analysis of single cell constituents
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers

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JPH05184352A (ja) * 1990-01-16 1993-07-27 Centro De Ing Genetica Y Biotecnol ピヒア パストリス（Ｐｉｃｈｉａ ｐａｓｔｏｒｉｓ）酵母中での異種遺伝子の発現方法、発現ベクターおよび形質転換微生物
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Also Published As

Publication number Publication date
CN1402788A (zh) 2003-03-12
SG127720A1 (en) 2006-12-29
EA200200410A1 (ru) 2002-10-31
AU767827B2 (en) 2003-11-27
DE60019147T2 (de) 2006-05-11
YU22502A (sh) 2005-07-19
KR20020047208A (ko) 2002-06-21
KR20060114034A (ko) 2006-11-03
EP1605049A2 (en) 2005-12-14
AU7625400A (en) 2001-05-10
ES2240167T3 (es) 2005-10-16
PT1224298E (pt) 2005-06-30
US20080058256A1 (en) 2008-03-06
HUP0202650A3 (en) 2005-01-28
ATE292180T1 (de) 2005-04-15
BG106577A (bg) 2003-04-30
RS20060033A (sr) 2006-12-15
CA2386185A1 (en) 2001-04-12
MXPA02003126A (es) 2002-09-30
HK1049351B (zh) 2005-07-29
EA200400290A1 (ru) 2005-02-24
YU59604A (sh) 2005-11-28
CZ20021034A3 (cs) 2003-06-18
WO2001025445A1 (en) 2001-04-12
CN100357430C (zh) 2007-12-26
EP1224298A1 (en) 2002-07-24
BR0014414A (pt) 2002-06-11
DK1224298T3 (da) 2005-05-30
KR100711312B1 (ko) 2007-04-27
CZ298502B6 (cs) 2007-10-24
US20020058322A1 (en) 2002-05-16
EP1224298B1 (en) 2005-03-30
NO20021501D0 (no) 2002-03-26
US7195903B2 (en) 2007-03-27
NZ517951A (en) 2004-02-27
HK1049351A1 (en) 2003-05-09
PL355017A1 (en) 2004-03-22
EP1605049A3 (en) 2006-12-13
KR100700753B1 (ko) 2007-03-28
US6261820B1 (en) 2001-07-17
NO20021501L (no) 2002-05-31
US20030186422A1 (en) 2003-10-02
SK4232002A3 (en) 2003-09-11
DE60019147D1 (en) 2005-05-04
CN101230340A (zh) 2008-07-30
IL148787A0 (en) 2002-09-12
ZA200202206B (en) 2002-12-24
JP2003511034A (ja) 2003-03-25
EA005944B1 (ru) 2005-08-25
EA006487B1 (ru) 2005-12-29
US6617145B2 (en) 2003-09-09

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees