YU22502A - Fibrinolitički aktivni polipeptid - Google Patents

Fibrinolitički aktivni polipeptid

Info

Publication number
YU22502A
YU22502A YU22502A YUP22502A YU22502A YU 22502 A YU22502 A YU 22502A YU 22502 A YU22502 A YU 22502A YU P22502 A YUP22502 A YU P22502A YU 22502 A YU22502 A YU 22502A
Authority
YU
Yugoslavia
Prior art keywords
fibrinolitically
active polypeptide
vivo
useful
called
Prior art date
Application number
YU22502A
Other languages
English (en)
Inventor
Thomas Charles Boone
Huimin Li
Michael Benjamin Mann
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Priority to YUP-2006/0033A priority Critical patent/RS20060033A/sr
Publication of YU22502A publication Critical patent/YU22502A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Opisan je fibrinolitički aktivan polipeptid metaloproteinaza (SEQ ID NO:1), njegova primena i postupci i materijali za njegovu proizvodnju rekombinantnom ekspresijom. MRFPSIFTAV LFAASSALAA PVNTTTEDET AOIPAEAVIG YSDLEGDFDV AVLPESNSTN NGLLPINTTI ASIAAKEEGV SLEKREAEAS SIILESGNVN DYEVVYPRKV TPVPRGAVOP KYEDAMOYEF KVNSEPVVLH LEKNKGLFSE DYSETHYSPD GREITTYPLG EDHCYYHGEI ENDADSTASI SACNGLKGHF KLOGEMYLIE PLELSDSEAH AVYKYENVEK EDEAPKMCGV TONWESYEPI KKAFOLNLTK RSFPQRYVQL VIVADHRMNT KYNGDSDKIR QWVHQIVNTI NEIYRPLNIQ FTLVGLEIWS NQDLITVTSV SHDTLASFGN WRETDLLRRQ RHDNAQLLTA IDFDGDTVGL AYVGGMCQLR HSTGVIQDHS AINLLVALTM AHELGHNLGM NHDGNQCHCG ANSCVMAAML SDQPSKLFSD CSKKDYQTFL TVNNPQCILN KP[A fibrinolytically active metalloproteinase polypeptide (called "novel acting thrombolytic") which is useful for blood clot lysis in vivo and methods and materials for its production by recombinant expression are described.
YU22502A 1999-10-01 2000-09-20 Fibrinolitički aktivni polipeptid YU22502A (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YUP-2006/0033A RS20060033A (sr) 1999-10-01 2000-09-29 Fibrinolitički aktivan polipeptid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/411,329 US6261820B1 (en) 1999-10-01 1999-10-01 Fibronolytically active polypeptide

Publications (1)

Publication Number Publication Date
YU22502A true YU22502A (sh) 2005-07-19

Family

ID=23628486

Family Applications (2)

Application Number Title Priority Date Filing Date
YU59604A YU59604A (sh) 1999-10-01 2000-09-20 Fibrinolitički aktivan polipeptid
YU22502A YU22502A (sh) 1999-10-01 2000-09-20 Fibrinolitički aktivni polipeptid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU59604A YU59604A (sh) 1999-10-01 2000-09-20 Fibrinolitički aktivan polipeptid

Country Status (29)

Country Link
US (4) US6261820B1 (sh)
EP (2) EP1605049A3 (sh)
JP (1) JP2003511034A (sh)
KR (2) KR100711312B1 (sh)
CN (2) CN101230340A (sh)
AT (1) ATE292180T1 (sh)
AU (1) AU767827B2 (sh)
BG (1) BG106577A (sh)
BR (1) BR0014414A (sh)
CA (1) CA2386185A1 (sh)
CZ (1) CZ298502B6 (sh)
DE (1) DE60019147T2 (sh)
DK (1) DK1224298T3 (sh)
EA (2) EA005944B1 (sh)
ES (1) ES2240167T3 (sh)
HK (1) HK1049351B (sh)
HU (1) HUP0202650A3 (sh)
IL (1) IL148787A0 (sh)
MX (1) MXPA02003126A (sh)
NO (1) NO20021501L (sh)
NZ (1) NZ517951A (sh)
PL (1) PL355017A1 (sh)
PT (1) PT1224298E (sh)
RS (1) RS20060033A (sh)
SG (1) SG127720A1 (sh)
SK (1) SK4232002A3 (sh)
WO (1) WO2001025445A1 (sh)
YU (2) YU59604A (sh)
ZA (1) ZA200202206B (sh)

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US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US7033776B2 (en) * 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
US6455269B1 (en) 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US6523647B2 (en) * 2001-05-21 2003-02-25 Hydro Mobile Inc. Elevating platform assembly
WO2003068047A2 (en) * 2002-02-11 2003-08-21 Gold - T Tech, Inc. Method for preventing thrombus formation
US7016409B2 (en) * 2003-11-12 2006-03-21 Sony Corporation Apparatus and method for use in providing dynamic bit rate encoding
ES2239532B1 (es) * 2004-02-06 2006-11-01 Proyecto De Biomedicina Cima S.L. Metodo para evaluar el riesgo y la predisposicion a desarrollar una patologia relacionada con la presencia de autoanticuerpos frente a epcr.
US20070141625A1 (en) * 2005-02-03 2007-06-21 Santos Jose H Method for assessing risk of and predisposition to development of a pathology related to the presence of anti-epcr autoantibodies
US20070225749A1 (en) 2006-02-03 2007-09-27 Martin Brian B Methods and devices for restoring blood flow within blocked vasculature
EP2403583B1 (en) 2009-03-06 2016-10-19 Lazarus Effect, Inc. Retrieval systems
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
EP3191605B1 (en) 2014-09-09 2022-07-27 The Broad Institute, Inc. A droplet-based method and apparatus for composite single-cell nucleic acid analysis
WO2016130647A1 (en) 2015-02-11 2016-08-18 Lazarus Effect, Inc. Expandable tip medical devices and methods
EP3268462B1 (en) 2015-03-11 2021-08-11 The Broad Institute, Inc. Genotype and phenotype coupling
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
WO2017075265A1 (en) 2015-10-28 2017-05-04 The Broad Institute, Inc. Multiplex analysis of single cell constituents
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers

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US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
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Also Published As

Publication number Publication date
US6261820B1 (en) 2001-07-17
BG106577A (bg) 2003-04-30
EA005944B1 (ru) 2005-08-25
IL148787A0 (en) 2002-09-12
ES2240167T3 (es) 2005-10-16
CN1402788A (zh) 2003-03-12
EP1224298A1 (en) 2002-07-24
ZA200202206B (en) 2002-12-24
CZ298502B6 (cs) 2007-10-24
US7195903B2 (en) 2007-03-27
AU767827B2 (en) 2003-11-27
PL355017A1 (en) 2004-03-22
NO20021501L (no) 2002-05-31
DE60019147T2 (de) 2006-05-11
EA006487B1 (ru) 2005-12-29
JP2003511034A (ja) 2003-03-25
CZ20021034A3 (cs) 2003-06-18
HK1049351A1 (en) 2003-05-09
NZ517951A (en) 2004-02-27
WO2001025445A1 (en) 2001-04-12
US20030186422A1 (en) 2003-10-02
KR20020047208A (ko) 2002-06-21
MXPA02003126A (es) 2002-09-30
SG127720A1 (en) 2006-12-29
US20020058322A1 (en) 2002-05-16
KR100700753B1 (ko) 2007-03-28
KR100711312B1 (ko) 2007-04-27
RS20060033A (sr) 2006-12-15
EP1605049A3 (en) 2006-12-13
EA200200410A1 (ru) 2002-10-31
CA2386185A1 (en) 2001-04-12
EA200400290A1 (ru) 2005-02-24
DK1224298T3 (da) 2005-05-30
HK1049351B (zh) 2005-07-29
YU59604A (sh) 2005-11-28
PT1224298E (pt) 2005-06-30
EP1605049A2 (en) 2005-12-14
KR20060114034A (ko) 2006-11-03
HUP0202650A2 (hu) 2002-12-28
AU7625400A (en) 2001-05-10
CN100357430C (zh) 2007-12-26
DE60019147D1 (en) 2005-05-04
BR0014414A (pt) 2002-06-11
HUP0202650A3 (en) 2005-01-28
SK4232002A3 (en) 2003-09-11
ATE292180T1 (de) 2005-04-15
US6617145B2 (en) 2003-09-09
NO20021501D0 (no) 2002-03-26
CN101230340A (zh) 2008-07-30
US20080058256A1 (en) 2008-03-06
EP1224298B1 (en) 2005-03-30

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