DK0502872T3 - Fremgangsmåder og materialer til eksprimering af human plasminogenvariant - Google Patents

Fremgangsmåder og materialer til eksprimering af human plasminogenvariant

Info

Publication number
DK0502872T3
DK0502872T3 DK90916888.2T DK90916888T DK0502872T3 DK 0502872 T3 DK0502872 T3 DK 0502872T3 DK 90916888 T DK90916888 T DK 90916888T DK 0502872 T3 DK0502872 T3 DK 0502872T3
Authority
DK
Denmark
Prior art keywords
materials
methods
acylated
expressing human
human plasminogen
Prior art date
Application number
DK90916888.2T
Other languages
English (en)
Inventor
Francis J Castellino
Deborah L Higgins
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0502872T3 publication Critical patent/DK0502872T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK90916888.2T 1989-12-01 1990-10-31 Fremgangsmåder og materialer til eksprimering af human plasminogenvariant DK0502872T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/444,584 US5087572A (en) 1989-12-01 1989-12-01 Dna encoding human plasminogen modified at the cleavage site

Publications (1)

Publication Number Publication Date
DK0502872T3 true DK0502872T3 (da) 1994-09-12

Family

ID=23765514

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90916888.2T DK0502872T3 (da) 1989-12-01 1990-10-31 Fremgangsmåder og materialer til eksprimering af human plasminogenvariant

Country Status (14)

Country Link
US (1) US5087572A (da)
EP (1) EP0502872B1 (da)
JP (1) JP3043403B2 (da)
AT (1) ATE105862T1 (da)
AU (1) AU641449B2 (da)
CA (1) CA2072649C (da)
DE (1) DE69009068T2 (da)
DK (1) DK0502872T3 (da)
FI (1) FI102617B1 (da)
IE (1) IE62832B1 (da)
NO (1) NO307305B1 (da)
PL (1) PL288034A1 (da)
PT (1) PT96041A (da)
WO (1) WO1991008297A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
WO1992009893A1 (en) * 1990-11-29 1992-06-11 Carbaugh John E DIAGNOSTIC AND THERAPEUTIC COMPOSITIONS AND METHODS FOR LIPOPROTEIN(a)
AU664469B2 (en) 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
AU4661493A (en) * 1992-07-01 1994-01-31 Beth Israel Hospital Boston Enhancement of thrombolytic therapy with deglycosylated plasminogen
US6048850A (en) * 1992-09-22 2000-04-11 Young; Donald A. Method of inhibiting prostaglandin synthesis in a human host
US5837479A (en) * 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
US5919652A (en) * 1994-11-09 1999-07-06 The Regents Of The University Of California Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof
RU2564131C2 (ru) 2009-07-10 2015-09-27 ТромбоДженикс НВ Варианты плазминогена и плазмина
BR112013017172A2 (pt) 2011-01-05 2016-10-11 Thrombogenics Nv variantes de plasminogênio e plasmina
KR20140064841A (ko) 2011-08-12 2014-05-28 쓰롬보제닉스 엔.브이. 플라스미노겐 변이체 및 플라스민 변이체
CA3146963A1 (en) * 2019-07-12 2021-01-21 Monash University Methods for making recombinant protein
EP4281471A1 (en) * 2021-01-20 2023-11-29 Monash University Fusion proteins

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943245A (en) * 1974-02-14 1976-03-09 Armour Pharmaceutical Company Purification of plasminogen
EP0028489B1 (en) * 1979-11-05 1983-10-05 Beecham Group Plc Enzyme derivatives, and their preparation
AU5390286A (en) * 1985-01-25 1986-08-13 Sagami Chemical Research Center Stabilized human prourokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
EP0199574B1 (en) * 1985-04-22 1991-10-23 Genentech, Inc. Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
EP0292009A1 (en) * 1987-05-22 1988-11-23 Zymogenetics, Inc. Fibrinolytic proteins
ATE110772T1 (de) * 1987-06-04 1994-09-15 Zymogenetics Inc Mutierter t-pa mit kringle-ersatz.
IE67036B1 (en) * 1987-06-04 1996-05-15 Zymogenetics Inc Tissue plasminogen activator analogs having modified growth factor domains
WO1988010119A1 (en) * 1987-06-22 1988-12-29 Genetics Institute, Inc. Novel thrombolytic proteins

Also Published As

Publication number Publication date
CA2072649A1 (en) 1991-06-02
NO905211L (no) 1991-06-03
NO905211D0 (no) 1990-11-30
EP0502872B1 (en) 1994-05-18
FI905919A (fi) 1991-06-02
IE904332A1 (en) 1991-06-05
WO1991008297A1 (en) 1991-06-13
DE69009068D1 (de) 1994-06-23
AU6721290A (en) 1991-06-26
FI102617B (fi) 1999-01-15
JPH05502373A (ja) 1993-04-28
FI905919A0 (fi) 1990-11-30
JP3043403B2 (ja) 2000-05-22
AU641449B2 (en) 1993-09-23
NO307305B1 (no) 2000-03-13
EP0502872A1 (en) 1992-09-16
DE69009068T2 (de) 1994-10-27
FI102617B1 (fi) 1999-01-15
IE62832B1 (en) 1995-03-08
US5087572A (en) 1992-02-11
CA2072649C (en) 2003-10-21
PT96041A (pt) 1991-09-30
ATE105862T1 (de) 1994-06-15
PL288034A1 (en) 1991-08-12

Similar Documents

Publication Publication Date Title
DK0502872T3 (da) Fremgangsmåder og materialer til eksprimering af human plasminogenvariant
ATE124452T1 (de) Gewebe-plasminogenaktivator mit zymogenen oder fibrinspezifischen eigenschaften.
PT87721A (pt) Novel proteins with factor viii activity process for their preparation using generically engineered cells and pharmaceutical compositions containing them
DE3682891D1 (de) Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
DK431988D0 (da) Protein og dna til kodning deraf
GB2181741B (en) Enhancement of plasminogen activator production using heparin or low molecular weight heparin and an endothelial growth factor
FI915149A0 (fi) Foerfarande och material foer expression av humant plasminogen i ett eukaryotiskt cellsystem som saknar en laegesspecifik plasminogenaktivator.
AU3744889A (en) Variants of plasminogen activators and processes for their production
ES553803A0 (es) Procedimiento para determinar un activador de plasminogeno
DK0517756T3 (da) Vævs-plasminogenaktivator med fibrinspecifikke egenskaber
DK532886A (da) Farmaceutisk praeparat med thrombolytisk aktivitet og fremgangsmaade til fremstilling deraf
DK0381640T3 (da) Thrombolytiske præparater
DE3852118D1 (de) Protease-ähnliche zytotoxische lymphozyten-spezifische moleküle und verfahren.
DK104390A (da) Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne
ATE114170T1 (de) Substitutionsvariante des gewebeplasminogenaktivators.