NO905211D0 - Fremgangsmaater og materialer for ekspresjon av human plasminogenvariant. - Google Patents

Fremgangsmaater og materialer for ekspresjon av human plasminogenvariant.

Info

Publication number
NO905211D0
NO905211D0 NO905211A NO905211A NO905211D0 NO 905211 D0 NO905211 D0 NO 905211D0 NO 905211 A NO905211 A NO 905211A NO 905211 A NO905211 A NO 905211A NO 905211 D0 NO905211 D0 NO 905211D0
Authority
NO
Norway
Prior art keywords
expression
procedures
acylated
materials
plasminogen
Prior art date
Application number
NO905211A
Other languages
English (en)
Other versions
NO905211L (no
NO307305B1 (no
Inventor
Francis J Castellino
Deborah L Higgins
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO905211D0 publication Critical patent/NO905211D0/no
Publication of NO905211L publication Critical patent/NO905211L/no
Publication of NO307305B1 publication Critical patent/NO307305B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO905211A 1989-12-01 1990-11-30 Fremgangsmåter og materialer for ekspresjon av en variant av humant plasminogen NO307305B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/444,584 US5087572A (en) 1989-12-01 1989-12-01 Dna encoding human plasminogen modified at the cleavage site

Publications (3)

Publication Number Publication Date
NO905211D0 true NO905211D0 (no) 1990-11-30
NO905211L NO905211L (no) 1991-06-03
NO307305B1 NO307305B1 (no) 2000-03-13

Family

ID=23765514

Family Applications (1)

Application Number Title Priority Date Filing Date
NO905211A NO307305B1 (no) 1989-12-01 1990-11-30 Fremgangsmåter og materialer for ekspresjon av en variant av humant plasminogen

Country Status (14)

Country Link
US (1) US5087572A (no)
EP (1) EP0502872B1 (no)
JP (1) JP3043403B2 (no)
AT (1) ATE105862T1 (no)
AU (1) AU641449B2 (no)
CA (1) CA2072649C (no)
DE (1) DE69009068T2 (no)
DK (1) DK0502872T3 (no)
FI (1) FI102617B1 (no)
IE (1) IE62832B1 (no)
NO (1) NO307305B1 (no)
PL (1) PL288034A1 (no)
PT (1) PT96041A (no)
WO (1) WO1991008297A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
WO1992009893A1 (en) * 1990-11-29 1992-06-11 Carbaugh John E DIAGNOSTIC AND THERAPEUTIC COMPOSITIONS AND METHODS FOR LIPOPROTEIN(a)
AU664469B2 (en) 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
WO1994001128A1 (en) * 1992-07-01 1994-01-20 Beth Israel Hospital Boston Enhancement of thrombolytic therapy with deglycosylated plasminogen
US6048850A (en) * 1992-09-22 2000-04-11 Young; Donald A. Method of inhibiting prostaglandin synthesis in a human host
US5837479A (en) * 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
US5919652A (en) * 1994-11-09 1999-07-06 The Regents Of The University Of California Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof
MX2012000475A (es) 2009-07-10 2012-03-26 Thrombogenics Nv Variantes de plasminogeno y plasmina.
EP2661493B1 (en) 2011-01-05 2016-03-30 ThromboGenics N.V. Plasminogen and plasmin variants
CN103764163A (zh) 2011-08-12 2014-04-30 斯路姆基因公司 纤溶酶原和纤溶酶变体
JP2022540865A (ja) * 2019-07-12 2022-09-20 モナッシュ ユニバーシティ 組換えタンパク質を作製するための方法
EP4281471A1 (en) * 2021-01-20 2023-11-29 Monash University Fusion proteins

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943245A (en) * 1974-02-14 1976-03-09 Armour Pharmaceutical Company Purification of plasminogen
EP0028489B1 (en) * 1979-11-05 1983-10-05 Beecham Group Plc Enzyme derivatives, and their preparation
DE3680838D1 (de) * 1985-01-25 1991-09-19 Sagami Chem Res Stabilisierte menschliche prourokinase.
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
IL78571A (en) * 1985-04-22 1991-06-30 Genentech Inc Human tissue plasminogen activator mutants resistant to enzymatic cleavage resulting in two-chain form
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
DK275788A (da) * 1987-05-22 1989-02-03 Zymogenetics Inc Fibrinolytiske proteiner
ES2058180T3 (es) * 1987-06-04 1994-11-01 Zymogenetics Inc T-pa mutante con reemplazo de kringle.
DK302388A (da) * 1987-06-04 1989-02-03 Zymogenetics Inc T-pa analoger med dodificeret vaekstfaktordomaene
HUT51901A (en) * 1987-06-22 1990-06-28 Genetics Inst Process for production of new trombolitic ensimes

Also Published As

Publication number Publication date
FI905919A (fi) 1991-06-02
AU641449B2 (en) 1993-09-23
IE904332A1 (en) 1991-06-05
CA2072649C (en) 2003-10-21
PT96041A (pt) 1991-09-30
FI102617B (fi) 1999-01-15
NO905211L (no) 1991-06-03
FI102617B1 (fi) 1999-01-15
WO1991008297A1 (en) 1991-06-13
EP0502872A1 (en) 1992-09-16
NO307305B1 (no) 2000-03-13
AU6721290A (en) 1991-06-26
DE69009068T2 (de) 1994-10-27
US5087572A (en) 1992-02-11
FI905919A0 (fi) 1990-11-30
DK0502872T3 (da) 1994-09-12
JPH05502373A (ja) 1993-04-28
DE69009068D1 (de) 1994-06-23
JP3043403B2 (ja) 2000-05-22
EP0502872B1 (en) 1994-05-18
ATE105862T1 (de) 1994-06-15
PL288034A1 (en) 1991-08-12
IE62832B1 (en) 1995-03-08
CA2072649A1 (en) 1991-06-02

Similar Documents

Publication Publication Date Title
NO905211D0 (no) Fremgangsmaater og materialer for ekspresjon av human plasminogenvariant.
ATE124452T1 (de) Gewebe-plasminogenaktivator mit zymogenen oder fibrinspezifischen eigenschaften.
DE3682891D1 (de) Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
AU2036188A (en) New tissue plasminogen activator
GB2181741B (en) Enhancement of plasminogen activator production using heparin or low molecular weight heparin and an endothelial growth factor
FI915149A0 (fi) Foerfarande och material foer expression av humant plasminogen i ett eukaryotiskt cellsystem som saknar en laegesspecifik plasminogenaktivator.
AU3744889A (en) Variants of plasminogen activators and processes for their production
DK0517756T3 (da) Vævs-plasminogenaktivator med fibrinspecifikke egenskaber
PT83721B (pt) Processo de preparacao de composicoes farmaceuticas a base de activadores de plasminogenio com actividade trombolitica
DK0381640T3 (da) Thrombolytiske præparater
FI902066A0 (fi) Nya polypeptidfoereningar.
EP0300033A4 (en) PROTEASE-LIKE CYTOTOXIC LYMPHOCYTE-SPECIFIC MOLECULES AND METHOD.
EP0386240A4 (en) Novel polypeptide compounds
ATE114170T1 (de) Substitutionsvariante des gewebeplasminogenaktivators.
HAYASHI et al. Fibrin-affinity urokinase found in human urine
KR930701607A (ko) 하이브리드 플라스미노겐 활성제

Legal Events

Date Code Title Description
MK1K Patent expired