FI905919A0 - Foerfarande och material foer expression av en human plasminogenvariant. - Google Patents

Foerfarande och material foer expression av en human plasminogenvariant.

Info

Publication number
FI905919A0
FI905919A0 FI905919A FI905919A FI905919A0 FI 905919 A0 FI905919 A0 FI 905919A0 FI 905919 A FI905919 A FI 905919A FI 905919 A FI905919 A FI 905919A FI 905919 A0 FI905919 A0 FI 905919A0
Authority
FI
Finland
Prior art keywords
expression
acylated
plasminogenvariant
human
plasminogen
Prior art date
Application number
FI905919A
Other languages
English (en)
Other versions
FI102617B1 (fi
FI905919A (fi
FI102617B (fi
Inventor
Francis J Castellino
Deborah L Higgins
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FI905919A0 publication Critical patent/FI905919A0/fi
Publication of FI905919A publication Critical patent/FI905919A/fi
Application granted granted Critical
Publication of FI102617B1 publication Critical patent/FI102617B1/fi
Publication of FI102617B publication Critical patent/FI102617B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI905919A 1989-12-01 1990-11-30 Ihmisen plasminogeenin aminohappovarianttia koodittava nukleiinihappos ekvenssi, sitä sisältävä ekspressiovektori ja isäntäsolu sekä menetelm ä plasminogeenin aminohappovariantin valmistamiseksi ja menetelmä kaks oiskompleksin muodostamiseksi fibrinolyytt FI102617B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/444,584 US5087572A (en) 1989-12-01 1989-12-01 Dna encoding human plasminogen modified at the cleavage site
US44458489 1989-12-01

Publications (4)

Publication Number Publication Date
FI905919A0 true FI905919A0 (fi) 1990-11-30
FI905919A FI905919A (fi) 1991-06-02
FI102617B1 FI102617B1 (fi) 1999-01-15
FI102617B FI102617B (fi) 1999-01-15

Family

ID=23765514

Family Applications (1)

Application Number Title Priority Date Filing Date
FI905919A FI102617B (fi) 1989-12-01 1990-11-30 Ihmisen plasminogeenin aminohappovarianttia koodittava nukleiinihappos ekvenssi, sitä sisältävä ekspressiovektori ja isäntäsolu sekä menetelm ä plasminogeenin aminohappovariantin valmistamiseksi ja menetelmä kaks oiskompleksin muodostamiseksi fibrinolyytt

Country Status (14)

Country Link
US (1) US5087572A (fi)
EP (1) EP0502872B1 (fi)
JP (1) JP3043403B2 (fi)
AT (1) ATE105862T1 (fi)
AU (1) AU641449B2 (fi)
CA (1) CA2072649C (fi)
DE (1) DE69009068T2 (fi)
DK (1) DK0502872T3 (fi)
FI (1) FI102617B (fi)
IE (1) IE62832B1 (fi)
NO (1) NO307305B1 (fi)
PL (1) PL288034A1 (fi)
PT (1) PT96041A (fi)
WO (1) WO1991008297A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
AU9088891A (en) * 1990-11-29 1992-06-25 John E. Carbaugh Diagnostic and therapeutic compositions and methods for lipoprotein(a)
DE10199044I2 (de) 1992-06-03 2006-02-09 Genentech Inc Varianten des Gewebeplasminogenaktivators mit verbesserter Therapeutischer wirkung
WO1994001128A1 (en) * 1992-07-01 1994-01-20 Beth Israel Hospital Boston Enhancement of thrombolytic therapy with deglycosylated plasminogen
US5837479A (en) * 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
US6048850A (en) * 1992-09-22 2000-04-11 Young; Donald A. Method of inhibiting prostaglandin synthesis in a human host
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
US5919652A (en) * 1994-11-09 1999-07-06 The Regents Of The University Of California Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof
RU2564131C2 (ru) 2009-07-10 2015-09-27 ТромбоДженикс НВ Варианты плазминогена и плазмина
BR112013017172A2 (pt) 2011-01-05 2016-10-11 Thrombogenics Nv variantes de plasminogênio e plasmina
WO2013024074A1 (en) 2011-08-12 2013-02-21 Thrombogenics N.V. Plasminogen and plasmin variants
WO2021007612A1 (en) * 2019-07-12 2021-01-21 Monash University Methods for making recombinant protein
US20240100134A1 (en) * 2021-01-20 2024-03-28 Monash University Fusion proteins

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943245A (en) * 1974-02-14 1976-03-09 Armour Pharmaceutical Company Purification of plasminogen
EP0028489B1 (en) * 1979-11-05 1983-10-05 Beecham Group Plc Enzyme derivatives, and their preparation
WO1986004351A1 (en) * 1985-01-25 1986-07-31 Sagami Chemical Research Center Stabilized human prourokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
FR2581652B1 (fr) * 1985-04-22 1989-12-22 Genentech Inc Nouveaux mutants de l'activateur tissulaire du plasminogene humain
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
NO882226L (no) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiske proteiner.
DE3851259T2 (de) * 1987-06-04 1994-12-15 Zymogenetics Inc Mutierter t-PA mit Kringle-Ersatz.
ES2069536T3 (es) * 1987-06-04 1995-05-16 Zymogenetics Inc Analogos del activador del plasminogeno tisular que tienen dominios modificados del factor de crecimiento.
WO1988010119A1 (en) * 1987-06-22 1988-12-29 Genetics Institute, Inc. Novel thrombolytic proteins

Also Published As

Publication number Publication date
DK0502872T3 (da) 1994-09-12
JPH05502373A (ja) 1993-04-28
PL288034A1 (en) 1991-08-12
CA2072649C (en) 2003-10-21
WO1991008297A1 (en) 1991-06-13
NO307305B1 (no) 2000-03-13
IE62832B1 (en) 1995-03-08
EP0502872A1 (en) 1992-09-16
EP0502872B1 (en) 1994-05-18
US5087572A (en) 1992-02-11
FI102617B1 (fi) 1999-01-15
DE69009068T2 (de) 1994-10-27
JP3043403B2 (ja) 2000-05-22
FI905919A (fi) 1991-06-02
PT96041A (pt) 1991-09-30
NO905211L (no) 1991-06-03
NO905211D0 (no) 1990-11-30
ATE105862T1 (de) 1994-06-15
AU6721290A (en) 1991-06-26
DE69009068D1 (de) 1994-06-23
AU641449B2 (en) 1993-09-23
CA2072649A1 (en) 1991-06-02
FI102617B (fi) 1999-01-15
IE904332A1 (en) 1991-06-05

Similar Documents

Publication Publication Date Title
FI905919A0 (fi) Foerfarande och material foer expression av en human plasminogenvariant.
PT87721A (pt) Novel proteins with factor viii activity process for their preparation using generically engineered cells and pharmaceutical compositions containing them
ATE124452T1 (de) Gewebe-plasminogenaktivator mit zymogenen oder fibrinspezifischen eigenschaften.
NO880929L (no) Produksjon og bruk av il-6.
DE3682891D1 (de) Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
FI915149A0 (fi) Foerfarande och material foer expression av humant plasminogen i ett eukaryotiskt cellsystem som saknar en laegesspecifik plasminogenaktivator.
AU6341386A (en) Method of enhancing t-PA and SCU-PA production
DK0517756T3 (da) Vævs-plasminogenaktivator med fibrinspecifikke egenskaber
PT83721B (pt) Processo de preparacao de composicoes farmaceuticas a base de activadores de plasminogenio com actividade trombolitica
DK0381640T3 (da) Thrombolytiske præparater
EP0300033A4 (en) PROTEASE-LIKE CYTOTOXIC LYMPHOCYTE-SPECIFIC MOLECULES AND METHOD.
FI902066A0 (fi) Nya polypeptidfoereningar.
EP0386240A4 (en) Novel polypeptide compounds
KR930701607A (ko) 하이브리드 플라스미노겐 활성제
ATE114170T1 (de) Substitutionsvariante des gewebeplasminogenaktivators.
HAYASHI et al. Fibrin-affinity urokinase found in human urine

Legal Events

Date Code Title Description
FG Patent granted

Owner name: GENENTECH, INC.

FG Patent granted

Owner name: GENENTECH, INC.