HUP0200859A2 - Cikloalkil-szubsztituált benzimidazolok, ezeket tartalmazó gyógyszerkészítmények, előállításuk és alkalmazásuk - Google Patents

Cikloalkil-szubsztituált benzimidazolok, ezeket tartalmazó gyógyszerkészítmények, előállításuk és alkalmazásuk

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Publication number
HUP0200859A2
HUP0200859A2 HU0200859A HUP0200859A HUP0200859A2 HU P0200859 A2 HUP0200859 A2 HU P0200859A2 HU 0200859 A HU0200859 A HU 0200859A HU P0200859 A HUP0200859 A HU P0200859A HU P0200859 A2 HUP0200859 A2 HU P0200859A2
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HU
Hungary
Prior art keywords
compounds
group
cyclo
preparation
pharmaceutical compositions
Prior art date
Application number
HU0200859A
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English (en)
Inventor
Roland Grandel
Thomas Hörger
Michael Kock
Wilfried Lubisch
Reinhold Müller
Sabine Schult
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of HUP0200859A2 publication Critical patent/HUP0200859A2/hu
Publication of HUP0200859A3 publication Critical patent/HUP0200859A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgyát az általános képletű vegyületek - ahol A telítettvagy egyszeresen telítetlen karbociklus, amely 3-8 szénatomból áll, éstartalmazhat egy adott esetben diszubsztituált kondenzáltbenzolgyűrűt; R1 hidrogén-, halogénatom, alkil-, hidroxi-, nitro-,trifluor-metil-, cianocsoport, -NR11R12, -NH-CO-R13 általános képletűcsoport, alkoxi-csoport; és R2 hidrogénatom, alkil- vagy alkil-fenil-csoport és tautomereik, enantiomereik és diasztereomereik, lehetségescisz-transz izomereik és prodrugjaik, valamint alkalmazásuk képezik. Atalálmány szerinti vegyületek a poli(ADP-ribóz)-polimeráz (PARP) vagypoli(ADP-ribóz)-szintáz (PARS) inhibitorai. A találmány kiterjed avegyületek előállítására és a vegyületeket tartalmazógyógyszerkészítményekre is. Ó
HU0200859A 1999-04-22 2000-04-11 Cyclo-alkyl substituted benzimidazoles, pharmaceutical compositions containing them, their preparation and their use HUP0200859A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19918211A DE19918211A1 (de) 1999-04-22 1999-04-22 Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung

Publications (2)

Publication Number Publication Date
HUP0200859A2 true HUP0200859A2 (hu) 2002-11-28
HUP0200859A3 HUP0200859A3 (en) 2002-12-28

Family

ID=7905444

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200859A HUP0200859A3 (en) 1999-04-22 2000-04-11 Cyclo-alkyl substituted benzimidazoles, pharmaceutical compositions containing them, their preparation and their use

Country Status (27)

Country Link
US (1) US6737421B1 (hu)
EP (1) EP1171424B1 (hu)
JP (1) JP4002067B2 (hu)
KR (1) KR20020002435A (hu)
CN (1) CN1349510A (hu)
AR (1) AR023754A1 (hu)
AT (1) ATE432264T1 (hu)
AU (1) AU3965900A (hu)
BG (1) BG65513B1 (hu)
BR (1) BR0009948A (hu)
CA (1) CA2371174C (hu)
CO (1) CO5170500A1 (hu)
CZ (1) CZ20013775A3 (hu)
DE (2) DE19918211A1 (hu)
ES (1) ES2325674T3 (hu)
HK (1) HK1045513A1 (hu)
HU (1) HUP0200859A3 (hu)
IL (1) IL145882A0 (hu)
NO (1) NO20014963L (hu)
NZ (1) NZ514930A (hu)
PL (1) PL198919B1 (hu)
RU (1) RU2001131550A (hu)
SK (1) SK15222001A3 (hu)
TR (1) TR200103047T2 (hu)
TW (1) TWI278452B (hu)
WO (1) WO2000064878A1 (hu)
ZA (1) ZA200108204B (hu)

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EP1566380B1 (en) 2002-11-22 2012-01-11 Mitsubishi Tanabe Pharma Corporation Isoquinoline compounds and medicinal use thereof
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ES2378692T3 (es) 2005-09-29 2012-04-17 Abbott Laboratories Las 1H-benzimidazol-4-carboxamidas sustituidas con fenilo en la posición 2 son potentes inhibidores de PARP
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WO2007131016A2 (en) * 2006-05-02 2007-11-15 Abbott Laboratories Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
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BRPI0906020A2 (pt) 2008-01-08 2015-06-30 Merck Sharp & Dohme Sais farmaceuticamente aceitáveis de 2-{4-[ (3s) - piperidina-3-il ] fenil} -2h - indazol - 7 - carboxamida, uso e método de tratamento
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US10098857B2 (en) 2008-10-10 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
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CN102725412B (zh) 2009-11-27 2017-09-22 巴斯夫植物科学有限公司 优化的内切核酸酶及其用途
CA2781693C (en) 2009-11-27 2018-12-18 Basf Plant Science Company Gmbh Chimeric endonucleases and uses thereof
EP2504430A4 (en) 2009-11-27 2013-06-05 Basf Plant Science Co Gmbh CHIMERIC ENDONUCLEASES AND USES THEREOF
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JP5902299B2 (ja) * 2011-07-26 2016-04-13 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ Ｐａｒｐ−１阻害剤としての３−オキソ−２，３−ジヒドロ−１ｈ−インダゾール−４−カルボキサミド誘導体
PL2748111T3 (pl) 2011-11-17 2015-06-30 Alexander Schluttig Urządzenie i sposób wytwarzania sterylnej wody za pomocą sterylnego filtra cieczy z poprzecznym przepływem
JP6171003B2 (ja) * 2012-05-24 2017-07-26 ノバルティス アーゲー ピロロピロリジノン化合物
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Also Published As

Publication number Publication date
AU3965900A (en) 2000-11-10
BG65513B1 (bg) 2008-10-31
CA2371174C (en) 2007-02-20
TWI278452B (en) 2007-04-11
PL198919B1 (pl) 2008-07-31
CZ20013775A3 (cs) 2002-10-16
HUP0200859A3 (en) 2002-12-28
NO20014963D0 (no) 2001-10-12
BG105993A (en) 2002-05-31
SK15222001A3 (sk) 2002-06-04
JP4002067B2 (ja) 2007-10-31
AR023754A1 (es) 2002-09-04
IL145882A0 (en) 2002-07-25
BR0009948A (pt) 2002-01-08
CA2371174A1 (en) 2000-11-02
NZ514930A (en) 2003-10-31
ZA200108204B (en) 2004-05-26
TR200103047T2 (tr) 2002-05-21
DE19918211A1 (de) 2000-10-26
US6737421B1 (en) 2004-05-18
EP1171424A1 (de) 2002-01-16
NO20014963L (no) 2001-11-13
PL351557A1 (en) 2003-05-05
CO5170500A1 (es) 2002-06-27
JP2002543066A (ja) 2002-12-17
HK1045513A1 (zh) 2002-11-29
CN1349510A (zh) 2002-05-15
WO2000064878A1 (de) 2000-11-02
EP1171424B1 (de) 2009-05-27
KR20020002435A (ko) 2002-01-09
RU2001131550A (ru) 2004-02-27
ES2325674T3 (es) 2009-09-14
ATE432264T1 (de) 2009-06-15
DE50015651D1 (de) 2009-07-09

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