SK15222001A3 - Cykloalkylsubstituované benzimidazoly, ich príprava a použitie - Google Patents

Cykloalkylsubstituované benzimidazoly, ich príprava a použitie Download PDF

Info

Publication number
SK15222001A3
SK15222001A3 SK1522-2001A SK15222001A SK15222001A3 SK 15222001 A3 SK15222001 A3 SK 15222001A3 SK 15222001 A SK15222001 A SK 15222001A SK 15222001 A3 SK15222001 A3 SK 15222001A3
Authority
SK
Slovakia
Prior art keywords
alkyl
phenyl
treatment
formula
compounds
Prior art date
Application number
SK1522-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Wilfried Lubisch
Michael Kock
Thomas H�GER
Roland Grandel
Sabine Schult
Reinhold M�LLER
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of SK15222001A3 publication Critical patent/SK15222001A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
SK1522-2001A 1999-04-22 2000-04-11 Cykloalkylsubstituované benzimidazoly, ich príprava a použitie SK15222001A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19918211A DE19918211A1 (de) 1999-04-22 1999-04-22 Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung
PCT/EP2000/003231 WO2000064878A1 (de) 1999-04-22 2000-04-11 Cycloalkylsubstituierte benzimidazole und ihre verwendung als parp inhibitoren

Publications (1)

Publication Number Publication Date
SK15222001A3 true SK15222001A3 (sk) 2002-06-04

Family

ID=7905444

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1522-2001A SK15222001A3 (sk) 1999-04-22 2000-04-11 Cykloalkylsubstituované benzimidazoly, ich príprava a použitie

Country Status (27)

Country Link
US (1) US6737421B1 (hu)
EP (1) EP1171424B1 (hu)
JP (1) JP4002067B2 (hu)
KR (1) KR20020002435A (hu)
CN (1) CN1349510A (hu)
AR (1) AR023754A1 (hu)
AT (1) ATE432264T1 (hu)
AU (1) AU3965900A (hu)
BG (1) BG65513B1 (hu)
BR (1) BR0009948A (hu)
CA (1) CA2371174C (hu)
CO (1) CO5170500A1 (hu)
CZ (1) CZ20013775A3 (hu)
DE (2) DE19918211A1 (hu)
ES (1) ES2325674T3 (hu)
HK (1) HK1045513A1 (hu)
HU (1) HUP0200859A3 (hu)
IL (1) IL145882A0 (hu)
NO (1) NO20014963L (hu)
NZ (1) NZ514930A (hu)
PL (1) PL198919B1 (hu)
RU (1) RU2001131550A (hu)
SK (1) SK15222001A3 (hu)
TR (1) TR200103047T2 (hu)
TW (1) TWI278452B (hu)
WO (1) WO2000064878A1 (hu)
ZA (1) ZA200108204B (hu)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2003127367A (ru) 2001-03-12 2005-03-20 Аванир Фармасьютиклз (Us) Бензимидазоловые соединения для модулирования ige и ингибирования клеточной пролиферации
US7786344B2 (en) 2002-07-26 2010-08-31 Basf Plant Science Gmbh Selection method
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
WO2004024655A2 (en) 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
DK1557414T3 (da) 2002-10-01 2012-05-29 Mitsubishi Tanabe Pharma Corp IsoquinoIin-forbindelser og medicinsk anvendelse deraf
TW200412959A (en) 2002-11-22 2004-08-01 Mitsubishi Pharma Corp Isoquinoline compounds and medicinal use thereof
US9737511B2 (en) * 2004-05-24 2017-08-22 Geoffrey C. GURTNER Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
WO2005115379A2 (en) * 2004-05-24 2005-12-08 New York University Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
ATE541043T1 (de) 2005-03-08 2012-01-15 Basf Plant Science Gmbh Expressionsverstärkende intron-sequenz
TWI375673B (en) * 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
US7728026B2 (en) * 2005-04-11 2010-06-01 Abbott Laboratories, Inc. 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
ES2378692T3 (es) 2005-09-29 2012-04-17 Abbott Laboratories Las 1H-benzimidazol-4-carboxamidas sustituidas con fenilo en la posición 2 son potentes inhibidores de PARP
ATE461923T1 (de) * 2005-11-15 2010-04-15 Abbott Lab Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren
JP4611441B2 (ja) * 2006-04-03 2011-01-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール及びベンゾトリアゾール誘導体
ES2385849T3 (es) * 2006-05-02 2012-08-01 Abbott Laboratories Las 1H-bencimidazol-4-carboxamidas substituidas son potentes inhibidores de la PARP
WO2008084261A1 (en) 2007-01-10 2008-07-17 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
WO2008154129A1 (en) * 2007-06-08 2008-12-18 Bausch & Lomb Incorporated Pharmaceutical compositions and method for treating, reducing, ameliorating, alleviating, or preventing dry eye
US8067613B2 (en) * 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
US20090062268A1 (en) * 2007-08-27 2009-03-05 Lead Therapeutics, Inc. Novel inhibitors of poly(adp-ribose)polymerase (parp)
US8436185B2 (en) 2008-01-08 2013-05-07 Merck Sharp & Dohme Corp. Pharmaceutically acceptable salts of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
CN102027371A (zh) * 2008-05-16 2011-04-20 塞尔卓姆股份公司 Parp相互作用分子的鉴定方法和parp蛋白的纯化方法
US10098857B2 (en) 2008-10-10 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds
WO2010083199A1 (en) * 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase
EP2504439B1 (en) 2009-11-27 2016-03-02 BASF Plant Science Company GmbH Optimized endonucleases and uses thereof
US10316304B2 (en) 2009-11-27 2019-06-11 Basf Plant Science Company Gmbh Chimeric endonucleases and uses thereof
AU2010325564A1 (en) 2009-11-27 2012-07-12 Basf Plant Science Company Gmbh Chimeric endonucleases and uses thereof
CA2798697A1 (en) 2010-05-10 2011-11-17 Radikal Therapeutics Inc. Lipoic acid and nitroxide derivatives and uses thereof
RU2476224C2 (ru) * 2010-11-12 2013-02-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Российской академии медицинских наук (ФГБУ "НИИ фармакологии имени В.В. Закусова" РАМН) Лекарственное средство с кардиопротективной активностью
WO2013014038A1 (en) * 2011-07-26 2013-01-31 Nerviano Medical Sciences S.R.L. 3-oxo-2,3-dihydro-1h-indazole-4-carboxamide derivatives as parp-1 inhibitors
WO2013071941A1 (de) 2011-11-17 2013-05-23 Alexander Schluttig Vorrichtung und verfahren zur herstellung keimfreien wassers mittels eines querstrom-flüssigkeitssterilfiltes
US9365576B2 (en) * 2012-05-24 2016-06-14 Novartis Ag Pyrrolopyrrolidinone compounds
CA2977685C (en) 2015-03-02 2024-02-20 Sinai Health System Homologous recombination factors
DE102015006278B4 (de) 2015-05-15 2021-09-09 Alexander Schluttig Selbstdesinfizierender Geruchsverschluss
WO2019055490A1 (en) 2017-09-14 2019-03-21 The Board Of Trustees Of The Leland Stanford Junior University PACKAGING OF IRRADIED FABRIC FOR FAT GREETING RETENTION
WO2019101188A1 (en) 2017-11-25 2019-05-31 Beigene, Ltd. Novel benzoimidazoles as selective inhibitors of indoleamine 2, 3-dioxygenases
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE
WO2020233676A1 (en) * 2019-05-22 2020-11-26 Beigene, Ltd. Amide-substituted imidazo compounds as selective inhibitors of indoleamine 2, 3-dioxygenases

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2649125B1 (de) 1976-10-28 1978-01-12 Baelz Gmbh Helmut Warmwasserheizungs- oder -bereitungsanlage mi regelbarer Strahlpumpe
GR65025B (en) 1977-07-21 1980-06-16 Thomae Gmbh Dr K Method for the preparation of new imidazo-isokinolin-diones
DE2732951A1 (de) 1977-07-21 1979-02-08 Thomae Gmbh Dr K Neue imidazo-isochinolin-dione
DE3522230A1 (de) 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3546575A1 (de) 1985-12-21 1987-10-01 Daimler Benz Ag Einrichtung zur vortriebsregelung an kraftfahrzeugen
DE3545652A1 (de) 1985-12-21 1987-06-25 Daimler Benz Ag Einrichtung zur vortriebsregelung an kraftfahrzeugen
DE3830060A1 (de) 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh 2-phenylbenzimidazole - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
GB9121776D0 (en) * 1991-10-14 1991-11-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives and process for preparation thereof
KR950704228A (ko) 1992-12-02 1995-11-17 알렌 제이. 스피겔 선택적 포스포디에스테르가수분해효소 iv형(pde_iv) 저해제로서의 카테콜 디에테르(catecol diethers as selective pde_iv inhibitors)
ES2183004T3 (es) 1995-08-02 2003-03-16 Univ Newcastle Ventures Ltd Compuestos de benzimidazol.
AU3102697A (en) 1996-06-19 1998-01-07 Rhone-Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
AU4054197A (en) 1996-08-14 1998-03-06 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
GB9702701D0 (en) 1997-02-01 1997-04-02 Univ Newcastle Ventures Ltd Quinazolinone compounds

Also Published As

Publication number Publication date
CN1349510A (zh) 2002-05-15
BR0009948A (pt) 2002-01-08
CA2371174A1 (en) 2000-11-02
US6737421B1 (en) 2004-05-18
NO20014963D0 (no) 2001-10-12
IL145882A0 (en) 2002-07-25
AU3965900A (en) 2000-11-10
CO5170500A1 (es) 2002-06-27
DE19918211A1 (de) 2000-10-26
TR200103047T2 (tr) 2002-05-21
ZA200108204B (en) 2004-05-26
RU2001131550A (ru) 2004-02-27
BG65513B1 (bg) 2008-10-31
DE50015651D1 (de) 2009-07-09
NZ514930A (en) 2003-10-31
HUP0200859A3 (en) 2002-12-28
CZ20013775A3 (cs) 2002-10-16
HK1045513A1 (zh) 2002-11-29
TWI278452B (en) 2007-04-11
AR023754A1 (es) 2002-09-04
PL198919B1 (pl) 2008-07-31
EP1171424B1 (de) 2009-05-27
KR20020002435A (ko) 2002-01-09
ES2325674T3 (es) 2009-09-14
EP1171424A1 (de) 2002-01-16
ATE432264T1 (de) 2009-06-15
WO2000064878A1 (de) 2000-11-02
PL351557A1 (en) 2003-05-05
JP2002543066A (ja) 2002-12-17
NO20014963L (no) 2001-11-13
JP4002067B2 (ja) 2007-10-31
HUP0200859A2 (hu) 2002-11-28
BG105993A (en) 2002-05-31
CA2371174C (en) 2007-02-20

Similar Documents

Publication Publication Date Title
US6737421B1 (en) Cyclo-alkyl substituted benzimidazoles and their use as PARP inhibitors
CA2350734C (en) 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
AU764216B2 (en) Substituted benzimidazoles and their use as parp inhibitors
US6696437B1 (en) Heterocyclically substituted benzimidazoles, the production and application thereof
ES2234318T3 (es) 2-fenil-benzimidazoles sustituidos, su preparacion y uso.
US20030134843A1 (en) Heterocyclic compounds and their use as parp inhibitors
MXPA01010673A (es) Benzimidazoles ciclo-alquil substituidos y su uso como inhibidores parp
MXPA01005197A (en) Substituted benzimidazoles and their use as parp inhibitors
MXPA01004869A (en) 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof