BRPI0906020A2 - Sais farmaceuticamente aceitáveis de 2-{4-[ (3s) - piperidina-3-il ] fenil} -2h - indazol - 7 - carboxamida, uso e método de tratamento - Google Patents
Sais farmaceuticamente aceitáveis de 2-{4-[ (3s) - piperidina-3-il ] fenil} -2h - indazol - 7 - carboxamida, uso e método de tratamentoInfo
- Publication number
- BRPI0906020A2 BRPI0906020A2 BRPI0906020-0A BRPI0906020A BRPI0906020A2 BR PI0906020 A2 BRPI0906020 A2 BR PI0906020A2 BR PI0906020 A BRPI0906020 A BR PI0906020A BR PI0906020 A2 BRPI0906020 A2 BR PI0906020A2
- Authority
- BR
- Brazil
- Prior art keywords
- indazol
- piperidin
- carboxamide
- phenyl
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1033308P | 2008-01-08 | 2008-01-08 | |
PCT/GB2009/000041 WO2009087381A1 (en) | 2008-01-08 | 2009-01-08 | Pharmaceutically acceptable salts of 2-{4-[(3s)-piperidin-3- yl]phenyl} -2h-indazole-7-carboxamide |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0906020A2 true BRPI0906020A2 (pt) | 2015-06-30 |
Family
ID=40404013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0906020-0A BRPI0906020A2 (pt) | 2008-01-08 | 2009-01-08 | Sais farmaceuticamente aceitáveis de 2-{4-[ (3s) - piperidina-3-il ] fenil} -2h - indazol - 7 - carboxamida, uso e método de tratamento |
Country Status (17)
Country | Link |
---|---|
US (1) | US8436185B2 (pt) |
EP (1) | EP2240466B1 (pt) |
JP (1) | JP5989965B2 (pt) |
KR (1) | KR101653548B1 (pt) |
CN (2) | CN106008460B (pt) |
AU (1) | AU2009203598B2 (pt) |
BR (1) | BRPI0906020A2 (pt) |
CA (1) | CA2711491C (pt) |
ES (1) | ES2548131T3 (pt) |
FR (1) | FR18C1020I2 (pt) |
IL (1) | IL206201A (pt) |
MX (1) | MX337421B (pt) |
NL (1) | NL300938I2 (pt) |
NZ (1) | NZ586675A (pt) |
RU (1) | RU2495035C2 (pt) |
WO (1) | WO2009087381A1 (pt) |
ZA (1) | ZA201003902B (pt) |
Families Citing this family (46)
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RU2011119478A (ru) | 2008-10-14 | 2012-11-27 | Нин Си | Соединения и способы применения |
KR20110133048A (ko) | 2009-03-21 | 2011-12-09 | 닝 시 | 아미노 에스테르 유도체, 그의 염 및 이용 방법 |
PL2534153T3 (pl) | 2010-02-12 | 2017-08-31 | Pfizer Inc. | Sole i polimorfy 8-fluoro-2-{4-[(metyloamino}metylo]fenylo}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-onu |
WO2014088983A1 (en) * | 2012-12-07 | 2014-06-12 | Merck Sharp & Dohme Corp. | Regioselective n-2 arylation of indazoles |
SI3157566T1 (sl) | 2014-06-17 | 2019-08-30 | Vertex Pharmaceuticals Incorporated | Postopek za zdravljenje raka z uporabo kombinacije inhibitorjev CHK1 in ATR |
MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
WO2016172332A1 (en) * | 2015-04-22 | 2016-10-27 | The University Of North Carolina At Chapel Hill | A novel compound for the treatment of ewing sarcoma and high-throughput assays for identifying small molecules that modulate aberrant chromatin accessibility |
MX2018003657A (es) | 2015-09-30 | 2018-04-30 | Vertex Pharma | Metodo para tratar cancer usando una combinacion de agentes que dañan el adn e inhibidores de proteina relacionada con ataxia telangiectasia y rad3 (atr). |
WO2017056498A1 (ja) * | 2015-09-30 | 2017-04-06 | 国立大学法人東北大学 | 糖尿病性腎症の判定マーカー |
FI3478286T3 (fi) | 2016-06-29 | 2024-03-14 | Tesaro Inc | Menetelmiä munasarjasyövän hoitamiseksi |
CN107663190B (zh) * | 2016-07-29 | 2020-06-09 | 钟桂发 | 一种尼拉帕尼及其中间体的制备方法以及中间体化合物 |
CA3031705A1 (en) | 2016-07-29 | 2018-02-01 | Janssen Pharmaceutica Nv | Treatment of prostate cancer with niraparib |
CN106432057A (zh) * | 2016-09-17 | 2017-02-22 | 青岛云天生物技术有限公司 | 一种制备(3s)‑3‑(4‑氨基苯基)哌啶‑1‑甲酸叔丁酯的方法 |
AU2017354070A1 (en) | 2016-11-01 | 2019-05-16 | Anaptysbio, Inc. | Antibodies directed against programmed death- 1 (PD-1) |
US20190284280A1 (en) | 2016-11-01 | 2019-09-19 | Anaptysbio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
KR102671283B1 (ko) | 2017-01-09 | 2024-06-03 | 테사로, 인코포레이티드 | 항tim-3 항체로 암을 치료하는 방법 |
PL3565844T3 (pl) | 2017-01-09 | 2023-06-12 | Tesaro Inc. | Sposoby leczenia nowotworów złośliwych przeciwciałami anty-pd-1 |
EP3606523A1 (en) * | 2017-03-27 | 2020-02-12 | Tesaro, Inc. | Niraparib formulations |
TWI761476B (zh) * | 2017-03-27 | 2022-04-21 | 美商提薩羅有限公司 | 尼拉帕尼(niraparib)組合物 |
WO2018187187A1 (en) * | 2017-04-04 | 2018-10-11 | Combiphos Catalysts, Inc. | Deuterated (s)-2-(4-(piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide |
JOP20190244A1 (ar) | 2017-04-13 | 2019-10-13 | Janssen Pharmaceutica Nv | تركيبة علاجية لسرطان البروستاتا |
WO2018200517A1 (en) | 2017-04-24 | 2018-11-01 | Tesaro, Inc. | Methods of manufacturing of niraparib |
WO2018201096A1 (en) | 2017-04-27 | 2018-11-01 | Tesaro, Inc. | Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof |
EP3624850A1 (en) * | 2017-05-18 | 2020-03-25 | Tesaro, Inc. | Combination therapies for treating cancer |
CN108530425A (zh) * | 2017-05-27 | 2018-09-14 | 广州科锐特生物科技有限公司 | 一种尼拉帕尼对甲苯磺酸盐水合物晶型及其制备方法 |
CN109081828B (zh) | 2017-06-14 | 2021-03-26 | 上海时莱生物技术有限公司 | 聚(adp-核糖)聚合酶抑制剂、制备方法及用途 |
US10927095B2 (en) | 2017-08-14 | 2021-02-23 | Teva Pharmaceuticals International Gmbh | Processes for the preparation of Niraparib and intermediates thereof |
EP3682245A1 (en) * | 2017-09-13 | 2020-07-22 | B.R.A.H.M.S GmbH | Pro-adm as a therapy monitoring marker for critcally ill patients |
US20200271666A1 (en) * | 2017-09-13 | 2020-08-27 | B.R.A.H.M.S Gmbh | Proadrenomedullin as indicator for renal replacement therapy in critically ill patients |
WO2019053117A1 (en) * | 2017-09-13 | 2019-03-21 | B.R.A.H.M.S Gmbh | PCT AND PRO-ADM USED AS CONTROL MARKERS IN ANTIBIOTIC TREATMENT |
SG11202002113TA (en) * | 2017-09-26 | 2020-04-29 | Tesaro Inc | Niraparib formulations |
MA50409A (fr) | 2017-09-30 | 2020-08-26 | Tesaro Inc | Polythérapies pour le traitement du cancer |
EA202090655A1 (ru) | 2017-10-06 | 2020-12-07 | Тесаро, Инк. | Комбинированные терапевтические средства и их применение |
WO2019133697A1 (en) | 2017-12-27 | 2019-07-04 | Tesaro, Inc. | Methods of treating cancer |
WO2019152989A1 (en) | 2018-02-05 | 2019-08-08 | Tesaro, Inc | Pediatric niraparib formulations and pediatric treatment methods |
US20210346497A1 (en) | 2018-09-04 | 2021-11-11 | Tesaro, Inc. | Methods of Treating Cancer |
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EP3966782A2 (en) | 2019-05-06 | 2022-03-16 | Tesaro, Inc. | Methods for characterizing and treating a cancer type using cancer images |
CN110407704B (zh) * | 2019-08-19 | 2022-05-17 | 常州沃腾化工科技有限公司 | 一种3-甲酰基-2-硝基苯甲酸甲酯的合成方法 |
WO2021224469A1 (en) | 2020-05-08 | 2021-11-11 | Janssen Pharmaceutica Nv | Treatments of prostate cancer with combinations of abiraterone acetate and niraparib |
MX2024000949A (es) | 2021-07-19 | 2024-02-08 | Janssen Pharmaceutica Nv | Tratamiento de cancer de prostata metastasico resistente a la castracion con niraparib. |
WO2023148345A1 (en) | 2022-02-04 | 2023-08-10 | Janssen Pharmaceutica Nv | Niraparib and abiraterone acetate plus prednisone to improve clinical outcomes in patients with metastatic castration-resistant prostate cancer and hrr alterations |
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2009
- 2009-01-08 AU AU2009203598A patent/AU2009203598B2/en active Active
- 2009-01-08 US US12/811,922 patent/US8436185B2/en active Active
- 2009-01-08 NZ NZ586675A patent/NZ586675A/en unknown
- 2009-01-08 CN CN201610345956.4A patent/CN106008460B/zh active Active
- 2009-01-08 EP EP09700579.7A patent/EP2240466B1/en active Active
- 2009-01-08 CA CA2711491A patent/CA2711491C/en active Active
- 2009-01-08 BR BRPI0906020-0A patent/BRPI0906020A2/pt not_active Application Discontinuation
- 2009-01-08 WO PCT/GB2009/000041 patent/WO2009087381A1/en active Application Filing
- 2009-01-08 KR KR1020107015011A patent/KR101653548B1/ko active IP Right Grant
- 2009-01-08 MX MX2010006593A patent/MX337421B/es active IP Right Grant
- 2009-01-08 ES ES09700579.7T patent/ES2548131T3/es active Active
- 2009-01-08 RU RU2010133241/04A patent/RU2495035C2/ru active
- 2009-01-08 CN CN2009801018616A patent/CN101932572A/zh active Pending
- 2009-01-08 JP JP2010541101A patent/JP5989965B2/ja active Active
-
2010
- 2010-06-01 ZA ZA2010/03902A patent/ZA201003902B/en unknown
- 2010-06-06 IL IL206201A patent/IL206201A/en active Protection Beyond IP Right Term
-
2018
- 2018-05-14 FR FR18C1020C patent/FR18C1020I2/fr active Active
- 2018-05-15 NL NL300938C patent/NL300938I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
RU2495035C2 (ru) | 2013-10-10 |
CN106008460A (zh) | 2016-10-12 |
WO2009087381A1 (en) | 2009-07-16 |
CN101932572A (zh) | 2010-12-29 |
RU2010133241A (ru) | 2012-02-20 |
ES2548131T3 (es) | 2015-10-14 |
EP2240466B1 (en) | 2015-07-29 |
NL300938I2 (nl) | 2019-01-08 |
MX337421B (es) | 2016-03-04 |
KR20100114021A (ko) | 2010-10-22 |
AU2009203598A1 (en) | 2009-07-16 |
IL206201A0 (en) | 2010-12-30 |
US8436185B2 (en) | 2013-05-07 |
CA2711491C (en) | 2016-03-08 |
MX2010006593A (es) | 2010-12-21 |
FR18C1020I2 (fr) | 2019-06-07 |
US20100286203A1 (en) | 2010-11-11 |
AU2009203598B2 (en) | 2013-09-26 |
IL206201A (en) | 2014-07-31 |
FR18C1020I1 (pt) | 2018-07-13 |
CN106008460B (zh) | 2022-08-12 |
KR101653548B1 (ko) | 2016-09-02 |
EP2240466A1 (en) | 2010-10-20 |
NZ586675A (en) | 2012-04-27 |
CA2711491A1 (en) | 2009-07-16 |
JP5989965B2 (ja) | 2016-09-07 |
ZA201003902B (en) | 2011-02-23 |
JP2011509252A (ja) | 2011-03-24 |
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