ATE11049T1 - Aktive pharmazeutische spirohydantoinderivate. - Google Patents
Aktive pharmazeutische spirohydantoinderivate.Info
- Publication number
- ATE11049T1 ATE11049T1 AT82302335T AT82302335T ATE11049T1 AT E11049 T1 ATE11049 T1 AT E11049T1 AT 82302335 T AT82302335 T AT 82302335T AT 82302335 T AT82302335 T AT 82302335T AT E11049 T1 ATE11049 T1 AT E11049T1
- Authority
- AT
- Austria
- Prior art keywords
- halogeno
- alkyl
- nitro
- formula
- independently selected
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
- 108010053754 Aldehyde reductase Proteins 0.000 abstract 1
- 208000027472 Galactosemias Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Dental Preparations (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8114399 | 1981-05-12 | ||
| EP82302335A EP0066378B1 (de) | 1981-05-12 | 1982-05-07 | Aktive pharmazeutische Spirohydantoinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE11049T1 true ATE11049T1 (de) | 1985-01-15 |
Family
ID=10521724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82302335T ATE11049T1 (de) | 1981-05-12 | 1982-05-07 | Aktive pharmazeutische spirohydantoinderivate. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4386100A (de) |
| EP (1) | EP0066378B1 (de) |
| JP (1) | JPS57192385A (de) |
| AT (1) | ATE11049T1 (de) |
| AU (1) | AU549265B2 (de) |
| CA (1) | CA1183142A (de) |
| DE (1) | DE3261751D1 (de) |
| IE (1) | IE52879B1 (de) |
| IL (1) | IL65603A0 (de) |
| NZ (1) | NZ200577A (de) |
| ZA (1) | ZA822792B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU566869B2 (en) * | 1982-05-11 | 1987-11-05 | Imperial Chemical Industries Plc | Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones |
| US4464380A (en) * | 1983-05-25 | 1984-08-07 | Pfizer Inc. | Imidazolidinedione derivatives |
| HU198212B (en) * | 1984-07-20 | 1989-08-28 | Pfizer | Process for production of spiro-imidasolones |
| US4911931A (en) * | 1987-08-03 | 1990-03-27 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
| US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
| US5068332A (en) * | 1990-10-12 | 1991-11-26 | American Home Products Corporation | Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors |
| US5102886A (en) * | 1990-10-12 | 1992-04-07 | American Home Products Corporation | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors |
| WO2006125784A1 (en) | 2005-05-24 | 2006-11-30 | Laboratoires Serono S.A. | Tricyclic spiro derivatives as crth2 modulators |
| AR059265A1 (es) * | 2006-02-07 | 2008-03-19 | Astrazeneca Ab | Compuestos espiro condensados con actividad inhibitoria en el receptor vaniloide1 (vr1) |
| WO2007091948A2 (en) * | 2006-02-07 | 2007-08-16 | Astrazeneca Ab | Novel spiro [imidazolidine-4, 3´-indole] 2, 2´,5´(1h) triones for treatment of conditions associated with vanilloid receptor 1 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| AU532110B2 (en) * | 1979-11-13 | 1983-09-15 | Ici Ltd. | Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives |
-
1982
- 1982-04-20 IE IE929/82A patent/IE52879B1/en unknown
- 1982-04-21 AU AU82892/82A patent/AU549265B2/en not_active Ceased
- 1982-04-23 ZA ZA822792A patent/ZA822792B/xx unknown
- 1982-04-26 IL IL65603A patent/IL65603A0/xx not_active IP Right Cessation
- 1982-05-07 DE DE8282302335T patent/DE3261751D1/de not_active Expired
- 1982-05-07 AT AT82302335T patent/ATE11049T1/de not_active IP Right Cessation
- 1982-05-07 EP EP82302335A patent/EP0066378B1/de not_active Expired
- 1982-05-11 US US06/377,134 patent/US4386100A/en not_active Expired - Fee Related
- 1982-05-11 CA CA000402674A patent/CA1183142A/en not_active Expired
- 1982-05-11 NZ NZ200577A patent/NZ200577A/en unknown
- 1982-05-12 JP JP57078474A patent/JPS57192385A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL65603A0 (en) | 1982-11-30 |
| AU549265B2 (en) | 1986-01-23 |
| ZA822792B (en) | 1983-02-23 |
| NZ200577A (en) | 1984-09-28 |
| AU8289282A (en) | 1982-11-18 |
| DE3261751D1 (en) | 1985-02-14 |
| EP0066378A1 (de) | 1982-12-08 |
| IE52879B1 (en) | 1988-03-30 |
| US4386100A (en) | 1983-05-31 |
| JPS57192385A (en) | 1982-11-26 |
| EP0066378B1 (de) | 1985-01-02 |
| CA1183142A (en) | 1985-02-26 |
| IE820929L (en) | 1982-11-12 |
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| ATE11049T1 (de) | Aktive pharmazeutische spirohydantoinderivate. | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |