HUP0105079A3 - Indole derivatives and their use as mcp-1 antagonists, process for preparation of the compounds and medicaments containing them - Google Patents

Indole derivatives and their use as mcp-1 antagonists, process for preparation of the compounds and medicaments containing them

Info

Publication number
HUP0105079A3
HUP0105079A3 HU0105079A HUP0105079A HUP0105079A3 HU P0105079 A3 HUP0105079 A3 HU P0105079A3 HU 0105079 A HU0105079 A HU 0105079A HU P0105079 A HUP0105079 A HU P0105079A HU P0105079 A3 HUP0105079 A3 HU P0105079A3
Authority
HU
Hungary
Prior art keywords
mcp
antagonists
compounds
preparation
indole derivatives
Prior art date
Application number
HU0105079A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HUP0105079A2 publication Critical patent/HUP0105079A2/hu
Publication of HUP0105079A3 publication Critical patent/HUP0105079A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU0105079A 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists, process for preparation of the compounds and medicaments containing them HUP0105079A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9902461.4A GB9902461D0 (en) 1999-02-05 1999-02-05 Chemical compounds
PCT/GB2000/000265 WO2000046196A1 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists

Publications (2)

Publication Number Publication Date
HUP0105079A2 HUP0105079A2 (hu) 2002-04-29
HUP0105079A3 true HUP0105079A3 (en) 2002-11-28

Family

ID=10847084

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105079A HUP0105079A3 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists, process for preparation of the compounds and medicaments containing them

Country Status (27)

Country Link
US (1) US6737435B1 (enExample)
EP (1) EP1150952B1 (enExample)
JP (1) JP2002536359A (enExample)
KR (1) KR20010094755A (enExample)
CN (1) CN1339025A (enExample)
AR (1) AR022461A1 (enExample)
AT (1) ATE280757T1 (enExample)
AU (1) AU770856B2 (enExample)
BR (1) BR0007984A (enExample)
CA (1) CA2356898A1 (enExample)
CZ (1) CZ20012807A3 (enExample)
DE (1) DE60015296T2 (enExample)
EE (1) EE200100403A (enExample)
GB (1) GB9902461D0 (enExample)
HU (1) HUP0105079A3 (enExample)
ID (1) ID30401A (enExample)
IL (1) IL144611A0 (enExample)
IS (1) IS5980A (enExample)
MY (1) MY133209A (enExample)
NO (1) NO20013809L (enExample)
NZ (1) NZ512680A (enExample)
PL (1) PL350184A1 (enExample)
RU (1) RU2235090C2 (enExample)
SK (1) SK11152001A3 (enExample)
TR (1) TR200102233T2 (enExample)
WO (1) WO2000046196A1 (enExample)
ZA (1) ZA200105311B (enExample)

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US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
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JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
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ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
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KR101350077B1 (ko) * 2010-12-13 2014-01-14 한국화학연구원 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
JP6050264B2 (ja) 2011-03-16 2016-12-21 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
CN110087530A (zh) 2016-12-07 2019-08-02 普罗根尼蒂公司 胃肠道检测方法、装置和系统
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DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase
CN116726362A (zh) 2018-11-19 2023-09-12 比奥拉治疗股份有限公司 用生物治疗剂治疗疾病的方法和装置
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
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Also Published As

Publication number Publication date
DE60015296T2 (de) 2006-02-02
SK11152001A3 (sk) 2001-12-03
HUP0105079A2 (hu) 2002-04-29
EE200100403A (et) 2002-10-15
AU2121300A (en) 2000-08-25
AU770856B2 (en) 2004-03-04
KR20010094755A (ko) 2001-11-01
AR022461A1 (es) 2002-09-04
DE60015296D1 (de) 2004-12-02
IL144611A0 (en) 2002-05-23
CZ20012807A3 (cs) 2001-10-17
TR200102233T2 (tr) 2001-12-21
IS5980A (is) 2001-06-26
NZ512680A (en) 2003-11-28
EP1150952A1 (en) 2001-11-07
CA2356898A1 (en) 2000-08-10
CN1339025A (zh) 2002-03-06
ATE280757T1 (de) 2004-11-15
BR0007984A (pt) 2001-11-06
NO20013809L (no) 2001-10-02
US6737435B1 (en) 2004-05-18
NO20013809D0 (no) 2001-08-03
MY133209A (en) 2007-10-31
JP2002536359A (ja) 2002-10-29
PL350184A1 (en) 2002-11-18
ZA200105311B (en) 2002-09-27
WO2000046196A1 (en) 2000-08-10
EP1150952B1 (en) 2004-10-27
RU2001124567A (ru) 2004-01-10
GB9902461D0 (en) 1999-03-24
ID30401A (id) 2001-11-29
RU2235090C2 (ru) 2004-08-27

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