HUP0102884A2 - Eljárások aminosavak összekapcsolására bisz(triklór-metil)-karbonát alkalmazásával - Google Patents

Eljárások aminosavak összekapcsolására bisz(triklór-metil)-karbonát alkalmazásával

Info

Publication number
HUP0102884A2
HUP0102884A2 HU0102884A HUP0102884A HUP0102884A2 HU P0102884 A2 HUP0102884 A2 HU P0102884A2 HU 0102884 A HU0102884 A HU 0102884A HU P0102884 A HUP0102884 A HU P0102884A HU P0102884 A2 HUP0102884 A2 HU P0102884A2
Authority
HU
Hungary
Prior art keywords
trichloromethyl
bis
carbonate
processes
amino acids
Prior art date
Application number
HU0102884A
Other languages
English (en)
Inventor
Eliezer Falb
Yoseph Salitra
Tamar Yechezkel
Original Assignee
Peptor Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptor Ltd. filed Critical Peptor Ltd.
Publication of HUP0102884A2 publication Critical patent/HUP0102884A2/hu
Publication of HUP0102884A3 publication Critical patent/HUP0102884A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyamides (AREA)

Abstract

A találmány aminosav-kloridoknak bisz(triklór-metil)-karbonát (másnéven: trifoszgén) alkalmazásával történő in situ előállításáraszolgáló eljárásra vonatkozik; vonatkozik továbbá ennek az eljárásnakszilárd fázisú peptid-szintézis során történő alkalmazására és aszilárd hordozó funkcióanalizálására történő felhasználására. Ó
HU0102884A 1998-07-12 1999-07-11 Processes for coupling amino acids using bis-(trichloromethyl) carbonate HUP0102884A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12531498A IL125314A (en) 1998-07-12 1998-07-12 Processes for attaching amino acids using a bite - (trichloromethyl) carbonate
PCT/IL1999/000378 WO2000002898A1 (en) 1998-07-12 1999-07-11 Processes for coupling amino acids using bis-(trichloromethyl) carbonate

Publications (2)

Publication Number Publication Date
HUP0102884A2 true HUP0102884A2 (hu) 2002-01-28
HUP0102884A3 HUP0102884A3 (en) 2002-02-28

Family

ID=11071733

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102884A HUP0102884A3 (en) 1998-07-12 1999-07-11 Processes for coupling amino acids using bis-(trichloromethyl) carbonate

Country Status (14)

Country Link
US (2) US6512092B2 (hu)
EP (1) EP1097164A4 (hu)
JP (1) JP2002520331A (hu)
KR (1) KR20010071853A (hu)
CN (1) CN1317011A (hu)
AU (1) AU754560B2 (hu)
CA (1) CA2334076A1 (hu)
CZ (1) CZ296014B6 (hu)
HU (1) HUP0102884A3 (hu)
IL (1) IL125314A (hu)
NZ (1) NZ509304A (hu)
PL (1) PL345532A1 (hu)
WO (1) WO2000002898A1 (hu)
ZA (1) ZA200100370B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040091451A1 (en) * 2000-05-29 2004-05-13 Marie-Therese Charreyre Biocompatible polymer for fixing biological ligands
EP1373190A2 (de) * 2001-03-28 2004-01-02 Bayer Chemicals AG Verfahren zur herstellung von carbonsäureamiden
US7205385B2 (en) * 2004-11-12 2007-04-17 General Electric Company Polymerization method for the synthesis of polypeptide imaging agents
CN101203527A (zh) * 2005-05-31 2008-06-18 耶路撒冷希伯来大学伊森姆研究发展公司 主链环化的促黑皮质素激素（αMSH）类似物
FI20055653A (fi) * 2005-12-08 2007-06-09 Wallac Oy Leimausreagenssi
KR100831858B1 (ko) 2006-05-23 2008-05-22 한기종 새로운 펩타이드결합 생성방법
GB2472563B (en) * 2009-04-28 2013-02-27 Univ Leicester Method of preparing hairpin and cyclic polyamides
WO2011024175A1 (en) 2009-08-28 2011-03-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection
WO2013111129A1 (en) 2012-01-23 2013-08-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Stabilized peptide helices for inhibiting dimerization of chemokine c motif receptor 2 (ccr2)
WO2015087334A1 (en) 2013-12-15 2015-06-18 Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. Viperistatin-derived peptides and uses thereof
WO2017212477A1 (en) 2016-06-07 2017-12-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (myd88)
JP7229158B2 (ja) 2017-06-09 2023-02-27 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
US11261215B2 (en) 2017-09-19 2022-03-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Somatostatin prodrugs
JP7434169B2 (ja) * 2018-04-10 2024-02-20 サノフィ－アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 固相からの固相結合ペプチドの切断方法
CN110818771B (zh) * 2018-08-14 2023-01-17 陈铭 使用氨基酸离子液体的羰基硫介导多肽合成
KR20210098476A (ko) 2018-11-30 2021-08-10 추가이 세이야쿠 가부시키가이샤 펩티드 화합물 또는 아마이드 화합물의 탈보호법 및 고상 반응에 있어서의 탈수지 방법, 및 펩티드 화합물의 제조 방법
EP3927737A1 (en) 2019-02-21 2021-12-29 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Par4 derived peptides, analogs and uses thereof
WO2022003673A1 (en) 2020-06-30 2022-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Humanin analogs and uses thereof
CN114047269B (zh) * 2022-01-13 2022-04-15 浙江湃肽生物有限公司南京分公司 一种乙酰基六肽-8的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3440141A1 (de) * 1984-11-02 1986-05-07 Heiner Dipl.-Chem. Dr. 8000 München Eckert Verwendung von kohlensaeure-bis-trichlormethylester als proreagens fuer phosgen
NZ243090A (en) 1991-06-18 1993-11-25 Lilly Co Eli Method of identifying active peptides and synthesis of peptide mixtures with a known amino acid in the last coupled position
US5198548A (en) * 1992-01-30 1993-03-30 Warner-Lambert Company Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof

Also Published As

Publication number Publication date
AU4645499A (en) 2000-02-01
KR20010071853A (ko) 2001-07-31
IL125314A (en) 2004-07-25
US20010007037A1 (en) 2001-07-05
ZA200100370B (en) 2001-07-26
EP1097164A1 (en) 2001-05-09
CA2334076A1 (en) 2000-01-20
EP1097164A4 (en) 2005-05-25
CZ296014B6 (cs) 2005-12-14
CN1317011A (zh) 2001-10-10
JP2002520331A (ja) 2002-07-09
PL345532A1 (en) 2001-12-17
NZ509304A (en) 2003-01-31
HUP0102884A3 (en) 2002-02-28
CZ2001159A3 (cs) 2001-09-12
US6512092B2 (en) 2003-01-28
US20030195331A1 (en) 2003-10-16
IL125314A0 (en) 1999-03-12
WO2000002898A1 (en) 2000-01-20
US7045592B2 (en) 2006-05-16
AU754560B2 (en) 2002-11-21

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees