ATE293125T1 - Ligationsverfahren und reagenzien zur bildung einer amid-bindung - Google Patents
Ligationsverfahren und reagenzien zur bildung einer amid-bindungInfo
- Publication number
- ATE293125T1 ATE293125T1 AT01935432T AT01935432T ATE293125T1 AT E293125 T1 ATE293125 T1 AT E293125T1 AT 01935432 T AT01935432 T AT 01935432T AT 01935432 T AT01935432 T AT 01935432T AT E293125 T1 ATE293125 T1 AT E293125T1
- Authority
- AT
- Austria
- Prior art keywords
- reagents
- formation
- amide bond
- amide
- forming
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 150000001540 azides Chemical class 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 238000010640 amide synthesis reaction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- QLQOTPOBMXWKOW-UHFFFAOYSA-N phosphinothious acid Chemical compound SP QLQOTPOBMXWKOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
- C07K1/082—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
- C07F9/4866—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the ester moiety containing a substituent or structure which is considered as characteristic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5004—Acyclic saturated phosphines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5022—Aromatic phosphines (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/505—Preparation; Separation; Purification; Stabilisation
- C07F9/5054—Preparation; Separation; Purification; Stabilisation by a process in which the phosphorus atom is not involved
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20399400P | 2000-05-12 | 2000-05-12 | |
| US20937300P | 2000-06-05 | 2000-06-05 | |
| US25562600P | 2000-12-13 | 2000-12-13 | |
| PCT/US2001/015440 WO2001087920A2 (en) | 2000-05-12 | 2001-05-11 | Ligation method and reagents to form an amide bond |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE293125T1 true ATE293125T1 (de) | 2005-04-15 |
Family
ID=27394606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01935432T ATE293125T1 (de) | 2000-05-12 | 2001-05-11 | Ligationsverfahren und reagenzien zur bildung einer amid-bindung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6972320B2 (de) |
| EP (1) | EP1399465B1 (de) |
| JP (1) | JP4694085B2 (de) |
| AT (1) | ATE293125T1 (de) |
| AU (2) | AU6153001A (de) |
| CA (1) | CA2405105C (de) |
| DE (1) | DE60110127T2 (de) |
| WO (1) | WO2001087920A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6570040B2 (en) | 2000-03-16 | 2003-05-27 | The Regents Of The University Of California | Chemoselective ligation |
| US7256259B2 (en) * | 2000-05-12 | 2007-08-14 | Wisconsin Alumni Research Foundation | Methods for ligation of molecules to surfaces |
| US6974884B2 (en) | 2002-06-07 | 2005-12-13 | Wisconsin Alumni Research Foundation | Chemical synthesis of reagents for peptide coupling |
| EP2001512A2 (de) * | 2006-03-28 | 2008-12-17 | Koninklijke Philips Electronics N.V. | Verwendung der staudinger-verbindung in einer in-vivo-anordnung einer biologisch aktiven verbindung |
| US8242058B2 (en) * | 2006-07-21 | 2012-08-14 | Wisconsin Alumni Research Foundation | Reagents and methods for appending functional groups to proteins |
| US8410247B2 (en) * | 2008-08-22 | 2013-04-02 | Wisconsin Alumni Research Foundation | Water-soluble phosphinothiol reagents |
| US8350014B2 (en) * | 2008-11-17 | 2013-01-08 | Wisconsin Alumni Research Foundation | Preparation of diazo and diazonium compounds |
| WO2010111737A1 (en) * | 2009-03-31 | 2010-10-07 | The University Of Sydney | Peptide and phosphopeptide synthesis via phosphate assisted ligation |
| GB0908711D0 (en) * | 2009-05-20 | 2009-07-01 | Isis Innovation | Preparation of labelled compounds |
| FR2952058B1 (fr) | 2009-10-29 | 2013-10-04 | Centre Nat Rech Scient | Procede de ligation native de polypeptides |
| FR2971509B1 (fr) | 2011-02-16 | 2013-02-22 | Centre Nat Rech Scient | Procede de preparation de peptides par assemblage de multiples fragments peptidiques |
| DE102011109187A1 (de) | 2011-08-02 | 2013-02-07 | Aptenia Srl | Immobilisierte Reagenzien für die Staudinger Kopplung mit "Imaging Tracern" |
| FR2981352B1 (fr) | 2011-10-17 | 2015-07-03 | Centre Nat Rech Scient | Procede de synthese de proteines |
| WO2013110005A1 (en) | 2012-01-18 | 2013-07-25 | Wisconsin Alumni Research Foundation | Boronate-mediated delivery of molecules into cells |
| US9732101B2 (en) | 2012-01-18 | 2017-08-15 | Wisconsin Alumni Research Foundation | Bioreversible boronates for delivery of molecules into cells |
| CA2864287C (en) | 2012-02-15 | 2021-01-12 | Wisconsin Alumni Research Foundation | Dithioamine reducing agents |
| FR2988392B1 (fr) | 2012-03-21 | 2014-04-11 | Centre Nat Rech Scient | Procede de ligation native |
| US9206271B2 (en) | 2012-03-25 | 2015-12-08 | Wisconsin Alumni Research Foundation | Fully backbone degradable and functionalizable polymers derived from the ring-opening metathesis polymerization (ROMP) |
| US9371521B2 (en) | 2014-06-30 | 2016-06-21 | Wisconsin Alumni Research Foundation | Substituted pyrazinedithiol reducing agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066684A (en) * | 1974-04-15 | 1978-01-03 | The Dow Chemical Company | Preparation of peptides |
| ATE85619T1 (de) | 1988-03-09 | 1993-02-15 | Cis Bio Int | Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen. |
| US5543389A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
| US5541289A (en) * | 1994-03-30 | 1996-07-30 | Washington University | Phosphine containing amino acids and peptides and methods of preparing and using same |
| US6570040B2 (en) | 2000-03-16 | 2003-05-27 | The Regents Of The University Of California | Chemoselective ligation |
-
2001
- 2001-05-11 AU AU6153001A patent/AU6153001A/xx active Pending
- 2001-05-11 DE DE60110127T patent/DE60110127T2/de not_active Expired - Lifetime
- 2001-05-11 EP EP01935432A patent/EP1399465B1/de not_active Expired - Lifetime
- 2001-05-11 JP JP2001585139A patent/JP4694085B2/ja not_active Expired - Fee Related
- 2001-05-11 WO PCT/US2001/015440 patent/WO2001087920A2/en active IP Right Grant
- 2001-05-11 AT AT01935432T patent/ATE293125T1/de not_active IP Right Cessation
- 2001-05-11 CA CA2405105A patent/CA2405105C/en not_active Expired - Fee Related
- 2001-05-11 AU AU2001261530A patent/AU2001261530B2/en not_active Ceased
- 2001-05-11 US US10/276,515 patent/US6972320B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2405105A1 (en) | 2001-11-22 |
| EP1399465A2 (de) | 2004-03-24 |
| WO2001087920A3 (en) | 2004-01-08 |
| EP1399465A4 (de) | 2004-03-31 |
| EP1399465B1 (de) | 2005-04-13 |
| JP4694085B2 (ja) | 2011-06-01 |
| US6972320B2 (en) | 2005-12-06 |
| AU6153001A (en) | 2001-11-26 |
| CA2405105C (en) | 2011-07-26 |
| DE60110127T2 (de) | 2006-02-02 |
| WO2001087920A2 (en) | 2001-11-22 |
| DE60110127D1 (de) | 2005-05-19 |
| US20040087779A1 (en) | 2004-05-06 |
| JP2004501103A (ja) | 2004-01-15 |
| AU2001261530B2 (en) | 2006-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |