BRPI0411766A - métodos para formar uma ligação de dissulfeto e para modificar quimicamente uma proteìna, um peptìdeo ou um aminoácido, composto, método para preparar o composto, uso do composto, e, proteìna, peptìdeo ou aminoácido - Google Patents

métodos para formar uma ligação de dissulfeto e para modificar quimicamente uma proteìna, um peptìdeo ou um aminoácido, composto, método para preparar o composto, uso do composto, e, proteìna, peptìdeo ou aminoácido

Info

Publication number
BRPI0411766A
BRPI0411766A BRPI0411766-2A BRPI0411766A BRPI0411766A BR PI0411766 A BRPI0411766 A BR PI0411766A BR PI0411766 A BRPI0411766 A BR PI0411766A BR PI0411766 A BRPI0411766 A BR PI0411766A
Authority
BR
Brazil
Prior art keywords
compound
peptide
protein
amino acid
methods
Prior art date
Application number
BRPI0411766-2A
Other languages
English (en)
Inventor
Benjamin Guy Davis
David Philip Gamblin
Anthony John Fairbanks
Philippe Garnier
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0314743A external-priority patent/GB0314743D0/en
Priority claimed from GB0328884A external-priority patent/GB0328884D0/en
Application filed by Isis Innovation filed Critical Isis Innovation
Publication of BRPI0411766A publication Critical patent/BRPI0411766A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"MéTODOS PARA FORMAR UMA LIGAçãO DE DISSULFETO E PARA MODIFICAR QUIMICAMENTE UMA PROTEìNA, UM PEPTìDEO OU UM AMINOáCIDO, COMPOSTO, MéTODO PARA PREPARAR O COMPOSTO, USO DO COMPOSTO, E, PROTEìNA, PEPTìDEO OU AMINOáCIDO". Métodos e reagentes para a formação de ligações de dissulfeto, particularmente em proteínas, peptídeos e aminoácidos. Os métodos e reagentes são particularmente úteis para a glicosilação controlada de proteínas, peptídeos e aminoácidos. Os métodos utilizam compostos de tiossulfonato ou de selenonil-sulfeto como reagentes ou intermediários. Algumas proteínas e alguns peptídeos compreendendo grupos de selenonil-sulfeto também formam parte da invenção.
BRPI0411766-2A 2003-06-24 2004-06-24 métodos para formar uma ligação de dissulfeto e para modificar quimicamente uma proteìna, um peptìdeo ou um aminoácido, composto, método para preparar o composto, uso do composto, e, proteìna, peptìdeo ou aminoácido BRPI0411766A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0314743A GB0314743D0 (en) 2003-06-24 2003-06-24 Reagents and methods
GB0328884A GB0328884D0 (en) 2003-12-12 2003-12-12 Methods
PCT/GB2004/002706 WO2005000862A2 (en) 2003-06-24 2004-06-24 Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins

Publications (1)

Publication Number Publication Date
BRPI0411766A true BRPI0411766A (pt) 2006-08-08

Family

ID=33554162

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411766-2A BRPI0411766A (pt) 2003-06-24 2004-06-24 métodos para formar uma ligação de dissulfeto e para modificar quimicamente uma proteìna, um peptìdeo ou um aminoácido, composto, método para preparar o composto, uso do composto, e, proteìna, peptìdeo ou aminoácido

Country Status (13)

Country Link
US (1) US8637578B2 (pt)
EP (1) EP1644390B1 (pt)
JP (1) JP4787155B2 (pt)
KR (1) KR20060019611A (pt)
AT (1) ATE506370T1 (pt)
AU (1) AU2004251105B2 (pt)
BR (1) BRPI0411766A (pt)
CA (1) CA2529341A1 (pt)
DE (1) DE602004032345D1 (pt)
EA (1) EA011299B1 (pt)
IL (1) IL172729A0 (pt)
NZ (1) NZ544654A (pt)
WO (1) WO2005000862A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507123D0 (en) * 2005-04-08 2005-05-11 Isis Innovation Method
CN1299603C (zh) * 2005-07-01 2007-02-14 浙江大学 糖基化谷类蛋白质－硒元素复合物制备方法
GB0602352D0 (en) * 2006-02-06 2006-03-15 Glycoform Ltd Glycoconjugation
US8420678B2 (en) 2008-04-14 2013-04-16 Board Of Regents, The University Of Texas System Small molecule inhibitors of the pleckstrin homology domain and methods for using same
CA2806148A1 (en) 2010-07-30 2012-02-02 Glycode A yeast artificial chromosome carrying the mammalian glycosylation pathway
EP2895592A1 (en) 2011-03-23 2015-07-22 Société Industrielle Limousine d'Application Biologique (SILAB) A yeast recombinant cell capable of producing gdp-fucose
WO2014093988A2 (en) 2012-12-14 2014-06-19 Phusis Therapeutics, Inc. Methods and compositions for inhibiting cnksr1
US11203776B2 (en) 2014-11-12 2021-12-21 Tumorend, Llc Compositions, methods and treatments for inhibiting cell adhesion and virus binding and penetration
WO2016172191A1 (en) 2015-04-20 2016-10-27 Phusis Therapeutics, Inc. Compounds, compositions and methods for inhibiting cnksr1
US11931428B2 (en) * 2019-08-23 2024-03-19 Wake Forest University Health Sciences Selective hydrogen sulfide probe and uses thereof
CN112979509B (zh) * 2021-03-10 2022-04-22 江西师范大学 一种三氟甲磺酰基炔酰胺类化合物及其制备方法和用途
WO2024050809A1 (zh) * 2022-09-09 2024-03-14 四川大学 一种蛋白和/或多肽糖基化修饰的方法
EP4346356A1 (en) 2022-09-29 2024-04-03 Novaled GmbH Semiconducting material, process for preparing a layer of the semiconducting material, organic semiconducting device comprising the semiconducting material and compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61205249A (ja) 1985-03-08 1986-09-11 Wako Pure Chem Ind Ltd 有機スルフイン酸塩の新規製法
DE3766567D1 (de) 1986-08-13 1991-01-17 Seitetsu Kagaku Co Ltd Verfahren zur herstellung von alkalimetallbenzolsulfinaten.
CA2106301C (en) * 1991-03-18 1999-04-06 Chi-Huey Wong Oligosaccharide enzyme substrates and inhibitors: method and compositions
CA2072763C (en) 1992-06-29 1994-05-17 Omar Chaudhry Process for the preparation of disulfides from thiols
AU728515B2 (en) * 1995-09-28 2001-01-11 Redox Pharmaceutical Corporation Metal complexes as cysteine protease inhibitors
DE69939538D1 (de) * 1998-07-02 2008-10-23 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine
WO2000064485A2 (en) 1999-04-28 2000-11-02 Genencor International, Inc. Specifically targeted catalytic antagonists and uses thereof
US6627744B2 (en) * 1999-07-02 2003-09-30 Genencor International, Inc. Synthesis of glycodendrimer reagents

Also Published As

Publication number Publication date
CA2529341A1 (en) 2005-01-06
IL172729A0 (en) 2006-04-10
US20070213506A1 (en) 2007-09-13
NZ544654A (en) 2009-05-31
ATE506370T1 (de) 2011-05-15
EA011299B1 (ru) 2009-02-27
JP2007527376A (ja) 2007-09-27
US8637578B2 (en) 2014-01-28
AU2004251105A1 (en) 2005-01-06
EP1644390A2 (en) 2006-04-12
DE602004032345D1 (de) 2011-06-01
JP4787155B2 (ja) 2011-10-05
EA200600042A1 (ru) 2006-08-25
WO2005000862A3 (en) 2005-08-18
AU2004251105B2 (en) 2010-04-01
KR20060019611A (ko) 2006-03-03
WO2005000862A2 (en) 2005-01-06
EP1644390B1 (en) 2011-04-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUI DADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.