HUP0101351A2 - Diklofenak transzdermális bevitelére szolgáló eszköz - Google Patents
Diklofenak transzdermális bevitelére szolgáló eszközInfo
- Publication number
- HUP0101351A2 HUP0101351A2 HU0101351A HUP0101351A HUP0101351A2 HU P0101351 A2 HUP0101351 A2 HU P0101351A2 HU 0101351 A HU0101351 A HU 0101351A HU P0101351 A HUP0101351 A HU P0101351A HU P0101351 A2 HUP0101351 A2 HU P0101351A2
- Authority
- HU
- Hungary
- Prior art keywords
- diclofenac
- alkyl
- carbon atoms
- transdermal delivery
- following
- Prior art date
Links
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001259 diclofenac Drugs 0.000 title abstract 2
- 230000037317 transdermal delivery Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
- -1 alkane polyol Chemical class 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 239000007933 dermal patch Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000037307 sensitive skin Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000003953 γ-lactams Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
A találmány tárgya nyomásra érzékeny bőrtapasz anyag, amely akövetkezőket tartalmazza: (a) egy vagy több, az alkil részben 4-12szénatomos alkil(met)akrilátból és egy vagy több hirofil monomerbőlálló kopolimer, (b) a következő penetrációt elősegítő anyag keveréke:(i) az alkilcsoportban 1-5 szénatomot tartalmazó alifás monokarbonsav-alkil-észter, (ii) egy 2-pirrolidon-származék, és (iii) egy alkánpoliol, és (c) diklofenak vagy gyógyszerészetileg elfogadható sójaterápiásan hatásos mennyisége. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8043198P | 1998-04-02 | 1998-04-02 | |
PCT/US1999/006779 WO1999051212A2 (en) | 1998-04-02 | 1999-03-29 | Device for the transdermal delivery of diclofenac |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101351A2 true HUP0101351A2 (hu) | 2001-09-28 |
HUP0101351A3 HUP0101351A3 (en) | 2002-10-28 |
Family
ID=22157332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101351A HUP0101351A3 (en) | 1998-04-02 | 1999-03-29 | Device for the transdermal delivery of diclofenac |
Country Status (12)
Country | Link |
---|---|
US (1) | US6193996B1 (hu) |
EP (1) | EP1067915A2 (hu) |
JP (1) | JP2002510617A (hu) |
KR (1) | KR20010042363A (hu) |
CN (1) | CN1296407A (hu) |
AU (1) | AU741377B2 (hu) |
CA (1) | CA2325400A1 (hu) |
HU (1) | HUP0101351A3 (hu) |
IL (1) | IL138534A0 (hu) |
NO (1) | NO20004935D0 (hu) |
PL (1) | PL343589A1 (hu) |
WO (1) | WO1999051212A2 (hu) |
Families Citing this family (53)
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US20020048596A1 (en) * | 1994-12-30 | 2002-04-25 | Gregor Cevc | Preparation for the transport of an active substance across barriers |
KR100548212B1 (ko) * | 1997-08-08 | 2006-04-06 | 빅테크노스 가부시키가이샤 | 아크릴계점착제조성물,점착테이프및점착제층의형성방법 |
ATE216223T1 (de) | 1999-01-27 | 2002-05-15 | Idea Ag | Transnasaler transport bzw. impfung mit hochadaptierbaren trägern |
EP1031346B1 (en) | 1999-01-27 | 2002-05-02 | Idea Ag | Noninvasive vaccination through the skin |
ES2197077T3 (es) * | 1999-03-01 | 2004-01-01 | Amarin Technologies S.A. | Dispositivo transdermico que comprende farmacos anti-inflamatorios no esteroides incorporados en una matriz de un polimero acrilico adhesivo. |
MXPA02000053A (es) * | 1999-07-05 | 2003-07-21 | Idea Ag | Un metodo para mejorar el tratamiento a traves de barreras adaptables semipermeables. |
US20070185542A1 (en) * | 2002-03-27 | 2007-08-09 | Cvrx, Inc. | Baroreflex therapy for disordered breathing |
US7840271B2 (en) * | 2000-09-27 | 2010-11-23 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US8086314B1 (en) * | 2000-09-27 | 2011-12-27 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
US7158832B2 (en) * | 2000-09-27 | 2007-01-02 | Cvrx, Inc. | Electrode designs and methods of use for cardiovascular reflex control devices |
US7623926B2 (en) * | 2000-09-27 | 2009-11-24 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US7616997B2 (en) * | 2000-09-27 | 2009-11-10 | Kieval Robert S | Devices and methods for cardiovascular reflex control via coupled electrodes |
US7499742B2 (en) * | 2001-09-26 | 2009-03-03 | Cvrx, Inc. | Electrode structures and methods for their use in cardiovascular reflex control |
DE10049225A1 (de) * | 2000-09-28 | 2002-04-11 | Labtec Gmbh | Dermales System, enthaltend Diclofenac |
US6902740B2 (en) * | 2001-07-09 | 2005-06-07 | 3M Innovative Properties Company | Pyrrolidonoethyl (meth)acrylate containing pressure sensitive adhesive compositions |
KR100446416B1 (ko) * | 2001-08-13 | 2004-09-01 | 아이큐어 주식회사 | 국소마취용 패치제 |
SE0103528D0 (sv) * | 2001-10-21 | 2001-10-21 | Jan Faergeman | Topiska kompositioner med förstärkt effekt |
US20040062794A1 (en) * | 2002-09-30 | 2004-04-01 | Lee Shulman | 17Beta- estradiol/levonorgestrel transdermal patch for hormone replacement therapy |
US20040105881A1 (en) * | 2002-10-11 | 2004-06-03 | Gregor Cevc | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin |
KR100554162B1 (ko) * | 2002-12-12 | 2006-02-22 | 한국전자통신연구원 | 올레아미드 또는 모노아세틸디글리세라이드가 함유된폴리(n-비닐 카프로락탐) 스마트 나노 입자 및 그 제조방법 |
EP1591110B1 (en) * | 2003-01-22 | 2015-03-18 | Senju Pharmaceutical Co., Ltd. | Percutaneous absorption preparation for treating ophthalmic disease, use thereof and method for migration of ophthalmic remedy into topical tissue in eye |
US20060111626A1 (en) * | 2003-03-27 | 2006-05-25 | Cvrx, Inc. | Electrode structures having anti-inflammatory properties and methods of use |
AU2004235794B8 (en) * | 2003-04-30 | 2009-07-23 | Purdue Pharma L.P. | Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer |
US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
US20050147570A1 (en) * | 2004-01-06 | 2005-07-07 | Nordsiek Michael T. | Methods of administering diclofenac compositions for treating photodamaged skin, rosacea and/or acne |
US8252319B2 (en) | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
PL1814531T3 (pl) | 2004-10-21 | 2010-11-30 | Durect Corp | Transdermalne systemy dostarczania |
WO2006050926A2 (en) * | 2004-11-12 | 2006-05-18 | Idea Ag | Extended surface aggregates in the treatment of skin conditions |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US20090238763A1 (en) * | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
CA2657435A1 (en) | 2006-07-10 | 2008-07-03 | Medipacs, Inc. | Super elastic epoxy hydrogel |
AU2006346759B2 (en) | 2006-07-25 | 2013-07-18 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of diclofenac with very fast skin penetration rate |
GB0622920D0 (en) * | 2006-11-17 | 2006-12-27 | Providence Capital Mangement | Topical treatment |
KR20220107078A (ko) * | 2007-06-04 | 2022-08-01 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(nsaia) 약물전구체 및 이들의 새로운 의약적 용도 |
MY151437A (en) | 2007-06-08 | 2014-05-30 | Troikaa Pharmaceuticals Ltd | A non-aqueous topical solution of diclofenac and process for preparing the same |
JP2011505520A (ja) | 2007-12-03 | 2011-02-24 | メディパックス インコーポレイテッド | 流体計量供給装置 |
CN111808011B (zh) | 2008-12-04 | 2024-02-27 | 泰飞尔生物医药(苏州)有限公司 | 高穿透性组合物及其应用 |
WO2011032011A1 (en) | 2009-09-10 | 2011-03-17 | Medipacs, Inc. | Low profile actuator and improved method of caregiver controlled administration of therapeutics |
CN102666699A (zh) * | 2009-10-07 | 2012-09-12 | Isp投资有限公司 | 增塑的聚合物组合物 |
US20130197092A1 (en) * | 2009-12-07 | 2013-08-01 | Ketan R. Patel | Novel Non-Aqueous Topical Solution of Diclofenac and Process for Preparing the Same |
US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
US20110172645A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Wearable drug delivery device including integrated pumping and activation elements |
US20110172639A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Device and method for delivery of microneedle to desired depth within the skin |
US20110172609A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
US9500186B2 (en) | 2010-02-01 | 2016-11-22 | Medipacs, Inc. | High surface area polymer actuator with gas mitigating components |
US20120197229A1 (en) * | 2010-08-04 | 2012-08-02 | Kalypto Medical, Inc. | Sacral wound dressing and method of manufacturing a wound therapy device |
WO2012061556A1 (en) | 2010-11-03 | 2012-05-10 | Flugen, Inc. | Wearable drug delivery device having spring drive and sliding actuation mechanism |
WO2012087749A1 (en) * | 2010-12-20 | 2012-06-28 | Polytherapeutics, Inc. | Composition for transdermal administration of non-steroidal anti-inflammatory drug |
ITMI20111355A1 (it) | 2011-07-20 | 2013-01-21 | Epifarma Srl | Cerotto transdermico contenente diclofenac e tiocolchicoside |
SG11201400067TA (en) | 2011-08-18 | 2014-04-28 | Otago Innovation Ltd | Cardiovascular therapeutics |
EP2847249A4 (en) | 2012-03-14 | 2016-12-28 | Medipacs Inc | SMART POLYMER MATERIALS WITH EXCESSIVE REACTIVE MOLECULES |
WO2014068600A1 (en) | 2012-11-02 | 2014-05-08 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising diclofenac |
EP3206673B1 (en) | 2014-10-17 | 2024-08-21 | Fidia Farmaceutici S.p.A. | Dermal therapeutic system with high adhesivity |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59227819A (ja) | 1983-06-09 | 1984-12-21 | Nitto Electric Ind Co Ltd | 消炎、鎮痛用貼付製剤 |
US4693776A (en) * | 1985-05-16 | 1987-09-15 | Minnesota Mining And Manufacturing Company | Macromer reinforced pressure sensitive skin adhesive |
JPS61293911A (ja) * | 1985-06-24 | 1986-12-24 | Teisan Seiyaku Kk | 徐放化製剤 |
JP2638635B2 (ja) | 1989-01-31 | 1997-08-06 | 積水化学工業株式会社 | 経皮吸収製剤 |
SE8904296D0 (sv) | 1989-12-21 | 1989-12-21 | Pharmacia Ab | Transdermal system |
JP2849937B2 (ja) | 1990-04-18 | 1999-01-27 | 日東電工株式会社 | 医療用貼付剤 |
JPH04261119A (ja) | 1991-02-13 | 1992-09-17 | Lintec Corp | 経皮吸収型貼付剤 |
WO1993000873A1 (en) * | 1991-07-03 | 1993-01-21 | Sano Corporation | Composition and method for transdermal delivery of diclofenac |
JP3086290B2 (ja) | 1991-07-26 | 2000-09-11 | エスエス製薬株式会社 | ジクロフェナクナトリウム貼付剤 |
GB2273044B (en) | 1992-12-02 | 1997-04-09 | Pacific Chem Co Ltd | Medicinal patches for percutaneous administration |
JPH07233050A (ja) | 1994-02-23 | 1995-09-05 | Sekisui Chem Co Ltd | 外用貼付剤 |
JPH09143066A (ja) | 1995-11-24 | 1997-06-03 | Sekisui Chem Co Ltd | 貼付剤 |
DE19653606A1 (de) | 1996-12-20 | 1998-06-25 | Roehm Gmbh | Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher |
-
1999
- 1999-03-25 US US09/276,630 patent/US6193996B1/en not_active Expired - Fee Related
- 1999-03-29 AU AU31188/99A patent/AU741377B2/en not_active Ceased
- 1999-03-29 CN CN99804873A patent/CN1296407A/zh active Pending
- 1999-03-29 HU HU0101351A patent/HUP0101351A3/hu unknown
- 1999-03-29 CA CA002325400A patent/CA2325400A1/en not_active Abandoned
- 1999-03-29 WO PCT/US1999/006779 patent/WO1999051212A2/en not_active Application Discontinuation
- 1999-03-29 EP EP99912931A patent/EP1067915A2/en not_active Withdrawn
- 1999-03-29 KR KR1020007010928A patent/KR20010042363A/ko not_active Application Discontinuation
- 1999-03-29 IL IL13853499A patent/IL138534A0/xx unknown
- 1999-03-29 JP JP2000541983A patent/JP2002510617A/ja active Pending
- 1999-03-29 PL PL99343589A patent/PL343589A1/xx unknown
-
2000
- 2000-09-29 NO NO20004935A patent/NO20004935D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
AU741377B2 (en) | 2001-11-29 |
US6193996B1 (en) | 2001-02-27 |
KR20010042363A (ko) | 2001-05-25 |
NO20004935L (no) | 2000-09-29 |
WO1999051212A3 (en) | 1999-12-02 |
EP1067915A2 (en) | 2001-01-17 |
AU3118899A (en) | 1999-10-25 |
JP2002510617A (ja) | 2002-04-09 |
WO1999051212A2 (en) | 1999-10-14 |
NO20004935D0 (no) | 2000-09-29 |
PL343589A1 (en) | 2001-08-27 |
CA2325400A1 (en) | 1999-10-14 |
CN1296407A (zh) | 2001-05-23 |
HUP0101351A3 (en) | 2002-10-28 |
IL138534A0 (en) | 2001-10-31 |
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