ES2178445T3 - Sistema de administracion transdermica que contiene hormonas e inhibidores de cristalizacion. - Google Patents

Sistema de administracion transdermica que contiene hormonas e inhibidores de cristalizacion.

Info

Publication number
ES2178445T3
ES2178445T3 ES99927905T ES99927905T ES2178445T3 ES 2178445 T3 ES2178445 T3 ES 2178445T3 ES 99927905 T ES99927905 T ES 99927905T ES 99927905 T ES99927905 T ES 99927905T ES 2178445 T3 ES2178445 T3 ES 2178445T3
Authority
ES
Spain
Prior art keywords
crystallization inhibitors
system containing
transdermal administration
administration system
containing hormones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99927905T
Other languages
English (en)
Inventor
Lucio Rovati
Antonino Santoro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm BV
Original Assignee
Rottapharm BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm BV filed Critical Rottapharm BV
Application granted granted Critical
Publication of ES2178445T3 publication Critical patent/ES2178445T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

Abstract

Sistema de administración transdérmica en forma de apósito para la transferencia controlada de estradiol en combinación con acetato de noretisterona, constituido por una capa superior, un reservorio sobresaturado de principios activos unido a ella, que contiene estradiol y acetato de noretisterona, el cual está fabricado a base de adhesivos de contacto de poliacrilato e inhibidores de cristalización, y una capa protectora amovible, caracterizado por ser el inhibidor de cristalización un terpolímero a base de metacrilato de butilo, metacrilato de 2-dimetilaminoetilo y metacrilato de metilo, particularmente en una relación molar de 1:2:1.
ES99927905T 1998-06-25 1999-06-08 Sistema de administracion transdermica que contiene hormonas e inhibidores de cristalizacion. Expired - Lifetime ES2178445T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19828274A DE19828274C2 (de) 1998-06-25 1998-06-25 Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren

Publications (1)

Publication Number Publication Date
ES2178445T3 true ES2178445T3 (es) 2002-12-16

Family

ID=7871951

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99927905T Expired - Lifetime ES2178445T3 (es) 1998-06-25 1999-06-08 Sistema de administracion transdermica que contiene hormonas e inhibidores de cristalizacion.

Country Status (7)

Country Link
EP (1) EP1089720B1 (es)
AT (1) ATE216876T1 (es)
AU (1) AU4508799A (es)
DE (2) DE19828274C2 (es)
ES (1) ES2178445T3 (es)
PT (1) PT1089720E (es)
WO (1) WO1999066907A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10025971B4 (de) * 2000-05-25 2004-09-02 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System in Plasterform mit verminderter Tendenz zur Wirkstoffkristallisation und seine Verwendung
DK1406633T3 (da) 2001-06-18 2011-10-31 Noven Pharma Forbedret lægemiddeltilførsel i transdermale systemer
JP6654365B2 (ja) * 2015-06-17 2020-02-26 日東電工株式会社 貼付製剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
DE4310012A1 (de) * 1993-03-27 1994-09-29 Roehm Gmbh Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung
DE4333595A1 (de) * 1993-10-01 1995-04-06 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut
DE19653605C2 (de) * 1996-12-20 2002-11-28 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems
DE19653606A1 (de) * 1996-12-20 1998-06-25 Roehm Gmbh Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher
DE19728517C2 (de) * 1997-07-04 1999-11-11 Sanol Arznei Schwarz Gmbh TTS zur Verabreichung von Sexualsteroidhormonen und Verfahren zu seiner Herstellung
IT1294748B1 (it) * 1997-09-17 1999-04-12 Permatec Tech Ag Formulazione per un dispositivo transdermico

Also Published As

Publication number Publication date
AU4508799A (en) 2000-01-10
DE19828274A1 (de) 1999-12-30
PT1089720E (pt) 2002-10-31
ATE216876T1 (de) 2002-05-15
EP1089720B1 (de) 2002-05-02
DE19828274C2 (de) 2002-11-28
DE59901355D1 (de) 2002-06-06
WO1999066907A1 (de) 1999-12-29
EP1089720A1 (de) 2001-04-11

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