CO4810224A1 - Dispositivo para el suministro transdermico de flurbiprofen - Google Patents

Dispositivo para el suministro transdermico de flurbiprofen

Info

Publication number
CO4810224A1
CO4810224A1 CO96067015A CO96067015A CO4810224A1 CO 4810224 A1 CO4810224 A1 CO 4810224A1 CO 96067015 A CO96067015 A CO 96067015A CO 96067015 A CO96067015 A CO 96067015A CO 4810224 A1 CO4810224 A1 CO 4810224A1
Authority
CO
Colombia
Prior art keywords
group
amount
alkyl
flurbiprofen
backing
Prior art date
Application number
CO96067015A
Other languages
English (en)
Inventor
Jochem J Effing
Kristin J Godbey
Eberhard A Gruhlke
Wolfgang Welsing
Original Assignee
Minnesota Mining & Mfg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining & Mfg filed Critical Minnesota Mining & Mfg
Publication of CO4810224A1 publication Critical patent/CO4810224A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un dispositivo para el suministro transdérmico que comprende:(a) un apoyo o refuerzo,(B) una capa de adhesivo adherida a una superficie del apoyo y que comprende una mezcla de:(1) un copolímero que comprende unidades interpolimerizadas suministradas a partir de:(a) uno o más monomeros A seleccionados a partir del grupo que consiste de acrilatos de alquilo que contienen desde 4 hasta 10 átomos de carbono en el grupo de alquilo y metalcrilatos de alquilo que contienen desde 4 hasta 10 átomos de carbono en el grupo alquilo; y(b) uno o más monómeros B etilénicamente no saturados que comprenden un grupo funcional seleccionado a partir del grupo que consiste de ácido carboxílico, sulfonamida, úrea, carbamato, carboxamida, hidroxi, amino, oxi, oxo y ciano; (2) flurbiprofen en una cantidad terapéuticamente efectiva;(3) miristato isopropilo en una cantidad de alrededor de 20 hasta alrededor de 40 porciento en peso basado en el peso total de la capa adhesiva; y(4) polivinilpirrolidona en una cantidad de alrededor de 1 hasta alrededor de 10 porciento en peso basado en el peso total de la capa adhesiva, conjuntamente tiene una rata de transmisión de vapor de humedad mayor de 400 g/m2 /24 horas.
CO96067015A 1995-12-22 1996-12-20 Dispositivo para el suministro transdermico de flurbiprofen CO4810224A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/577,482 US5702720A (en) 1995-12-22 1995-12-22 Transdermal device for the delivery of flurbiprofen

Publications (1)

Publication Number Publication Date
CO4810224A1 true CO4810224A1 (es) 1999-06-30

Family

ID=24308917

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96067015A CO4810224A1 (es) 1995-12-22 1996-12-20 Dispositivo para el suministro transdermico de flurbiprofen

Country Status (22)

Country Link
US (2) US5702720A (es)
EP (2) EP0869781B1 (es)
JP (2) JP2000503638A (es)
KR (2) KR19990076588A (es)
CN (2) CN1098071C (es)
AR (1) AR005163A1 (es)
AT (2) ATE241350T1 (es)
AU (2) AU701782B2 (es)
CA (2) CA2238400A1 (es)
CO (1) CO4810224A1 (es)
CZ (2) CZ197298A3 (es)
DE (2) DE69628448T2 (es)
HR (1) HRP960608B1 (es)
HU (1) HUP9901991A3 (es)
IL (2) IL124629A (es)
MX (2) MX9804871A (es)
MY (1) MY113685A (es)
NO (2) NO982613L (es)
NZ (2) NZ325659A (es)
TW (1) TW436298B (es)
WO (2) WO1997023205A1 (es)
ZA (1) ZA9610729B (es)

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Also Published As

Publication number Publication date
MY113685A (en) 2002-04-30
KR19990076589A (ko) 1999-10-15
AU1295097A (en) 1997-07-17
DE69628762T2 (de) 2004-04-29
EP0868177B1 (en) 2003-06-18
AU1422097A (en) 1997-07-17
KR19990076588A (ko) 1999-10-15
CZ197198A3 (cs) 1998-11-11
NO982764D0 (no) 1998-06-15
CN1098071C (zh) 2003-01-08
WO1997023205A1 (en) 1997-07-03
HUP9901991A2 (hu) 1999-10-28
CN1205631A (zh) 1999-01-20
NZ325659A (en) 2000-02-28
ATE241350T1 (de) 2003-06-15
AU701782B2 (en) 1999-02-04
EP0868177A1 (en) 1998-10-07
ATE243031T1 (de) 2003-07-15
IL124804A (en) 2001-12-23
IL124629A0 (en) 1998-12-06
CA2238400A1 (en) 1997-07-03
DE69628448T2 (de) 2004-04-08
MX9804969A (es) 1998-09-30
CA2240349A1 (en) 1997-07-03
KR100452001B1 (ko) 2004-12-30
WO1997023206A1 (en) 1997-07-03
HRP960608B1 (en) 2001-12-31
AR005163A1 (es) 1999-04-14
JP2000502349A (ja) 2000-02-29
EP0869781A1 (en) 1998-10-14
NO982764L (no) 1998-06-15
IL124804A0 (en) 1999-01-26
NO982613D0 (no) 1998-06-05
NO982613L (no) 1998-08-21
AU714798B2 (en) 2000-01-13
HRP960608A2 (en) 1997-10-31
CZ197298A3 (cs) 1999-01-13
DE69628762D1 (de) 2003-07-24
MX9804871A (es) 1998-10-31
IL124629A (en) 2001-10-31
US6086911A (en) 2000-07-11
EP0869781B1 (en) 2003-05-28
NZ325125A (en) 2000-05-26
JP2000503638A (ja) 2000-03-28
CN1098069C (zh) 2003-01-08
DE69628448D1 (de) 2003-07-03
ZA9610729B (en) 1998-06-19
US5702720A (en) 1997-12-30
CN1205630A (zh) 1999-01-20
TW436298B (en) 2001-05-28
HUP9901991A3 (en) 2001-04-28

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