AU4508799A - Transdermal therapeutic system containing hormones and crystallization inhibitors - Google Patents

Transdermal therapeutic system containing hormones and crystallization inhibitors

Info

Publication number
AU4508799A
AU4508799A AU45087/99A AU4508799A AU4508799A AU 4508799 A AU4508799 A AU 4508799A AU 45087/99 A AU45087/99 A AU 45087/99A AU 4508799 A AU4508799 A AU 4508799A AU 4508799 A AU4508799 A AU 4508799A
Authority
AU
Australia
Prior art keywords
transdermal therapeutic
therapeutic system
crystallization inhibitors
system containing
containing hormones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU45087/99A
Inventor
Lucio Rovati
Antonino Santoro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rottapharm BV
Original Assignee
Rottapharm BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm BV filed Critical Rottapharm BV
Publication of AU4508799A publication Critical patent/AU4508799A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to a transdermal therapeutic system in the form of a patch for controlled release of estradiol in combination with noresthisteron acetate, comprising a backing layer, a reservoir attached thereto and oversaturated with active substances, which is produced using polyacrylate contact-sensitive adhesives and crystallization inhibitors, in addition to a removable protective layer. The inventive system is characterized in that the crystallization inhibitor is a terpolymer based on butyl methacrylate, 2-dimethylamino ethylmethacrylate and methylmethacrylate, especially in a molar ratio of 1 : 2 : 1.
AU45087/99A 1998-06-25 1999-06-08 Transdermal therapeutic system containing hormones and crystallization inhibitors Abandoned AU4508799A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19828274 1998-06-25
DE19828274A DE19828274C2 (en) 1998-06-25 1998-06-25 Transdermal therapeutic system containing hormones and crystallization inhibitors
PCT/EP1999/003923 WO1999066907A1 (en) 1998-06-25 1999-06-08 Transdermal therapeutic system containing hormones and crystallization inhibitors

Publications (1)

Publication Number Publication Date
AU4508799A true AU4508799A (en) 2000-01-10

Family

ID=7871951

Family Applications (1)

Application Number Title Priority Date Filing Date
AU45087/99A Abandoned AU4508799A (en) 1998-06-25 1999-06-08 Transdermal therapeutic system containing hormones and crystallization inhibitors

Country Status (7)

Country Link
EP (1) EP1089720B1 (en)
AT (1) ATE216876T1 (en)
AU (1) AU4508799A (en)
DE (2) DE19828274C2 (en)
ES (1) ES2178445T3 (en)
PT (1) PT1089720E (en)
WO (1) WO1999066907A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10025971B4 (en) * 2000-05-25 2004-09-02 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system in plaster form with reduced tendency for drug crystallization and its use
TWI277418B (en) 2001-06-18 2007-04-01 Noven Pharma Enhanced drug delivery in transdermal systems
JP6654365B2 (en) * 2015-06-17 2020-02-26 日東電工株式会社 Patch preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
DE4310012A1 (en) * 1993-03-27 1994-09-29 Roehm Gmbh Dermal therapeutic system made of a meltable poly (meth) acrylate mixture
DE4333595A1 (en) * 1993-10-01 1995-04-06 Labtec Gmbh Transdermal therapeutic system for applying drugs to the skin
DE19653605C2 (en) * 1996-12-20 2002-11-28 Roehm Gmbh Adhesives and binders for dermal or transdermal therapy systems and their use for producing a transdermal therapy system
DE19653606A1 (en) * 1996-12-20 1998-06-25 Roehm Gmbh Adhesive and binder made from (meth) acrylate polymer, organic acid and plasticizer
DE19728517C2 (en) * 1997-07-04 1999-11-11 Sanol Arznei Schwarz Gmbh TTS for the administration of sex steroid hormones and process for its preparation
IT1294748B1 (en) * 1997-09-17 1999-04-12 Permatec Tech Ag FORMULATION FOR A TRANSDERMAL DEVICE

Also Published As

Publication number Publication date
WO1999066907A1 (en) 1999-12-29
PT1089720E (en) 2002-10-31
DE19828274C2 (en) 2002-11-28
DE19828274A1 (en) 1999-12-30
DE59901355D1 (en) 2002-06-06
ES2178445T3 (en) 2002-12-16
EP1089720A1 (en) 2001-04-11
EP1089720B1 (en) 2002-05-02
ATE216876T1 (en) 2002-05-15

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase