HUP0100335A3 - Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3 epoxysqualene lanesterol cyclase inhibitors - Google Patents
Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3 epoxysqualene lanesterol cyclase inhibitorsInfo
- Publication number
- HUP0100335A3 HUP0100335A3 HU0100335A HUP0100335A HUP0100335A3 HU P0100335 A3 HUP0100335 A3 HU P0100335A3 HU 0100335 A HU0100335 A HU 0100335A HU P0100335 A HUP0100335 A HU P0100335A HU P0100335 A3 HUP0100335 A3 HU P0100335A3
- Authority
- HU
- Hungary
- Prior art keywords
- lanesterol
- epoxysqualene
- azacycloalkanes
- thio
- production
- Prior art date
Links
- QYIMSPSDBYKPPY-BANQPHDMSA-N 2,3-epoxysqualene Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C=C(/C)CC\C=C(/C)CCC1OC1(C)C QYIMSPSDBYKPPY-BANQPHDMSA-N 0.000 title 1
- 101710095468 Cyclase Proteins 0.000 title 1
- 150000003976 azacycloalkanes Chemical class 0.000 title 1
- 125000004119 disulfanediyl group Chemical group *SS* 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 title 1
- 150000003673 urethanes Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Birds (AREA)
- Cardiology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19754796A DE19754796A1 (de) | 1997-12-10 | 1997-12-10 | Neue, von Azacycloalkanen abgeleitete Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| PCT/EP1998/007965 WO1999029669A1 (de) | 1997-12-10 | 1998-12-08 | Von azacycloalkanen abgeleitete urethane, ihre thio- und dithioanaloga, deren herstellung und deren verwendung als 2,3-epoxisqualen-lanosterol-cyclase inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100335A2 HUP0100335A2 (hu) | 2001-07-30 |
| HUP0100335A3 true HUP0100335A3 (en) | 2001-11-28 |
Family
ID=7851381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100335A HUP0100335A3 (en) | 1997-12-10 | 1998-12-08 | Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3 epoxysqualene lanesterol cyclase inhibitors |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1060162B1 (hu) |
| JP (1) | JP3418688B2 (hu) |
| KR (1) | KR20010032977A (hu) |
| CN (1) | CN1281434A (hu) |
| AR (1) | AR017827A1 (hu) |
| AT (1) | ATE234816T1 (hu) |
| AU (1) | AU1759499A (hu) |
| BG (1) | BG104500A (hu) |
| BR (1) | BR9813495A (hu) |
| CA (1) | CA2309388A1 (hu) |
| CO (1) | CO5370694A1 (hu) |
| DE (2) | DE19754796A1 (hu) |
| DK (1) | DK1060162T3 (hu) |
| EA (1) | EA200000631A1 (hu) |
| EE (1) | EE200000342A (hu) |
| ES (1) | ES2190130T3 (hu) |
| HR (1) | HRP20000377A2 (hu) |
| HU (1) | HUP0100335A3 (hu) |
| IL (1) | IL135738A0 (hu) |
| NO (1) | NO20002967L (hu) |
| PL (1) | PL341060A1 (hu) |
| PT (1) | PT1060162E (hu) |
| SK (1) | SK8612000A3 (hu) |
| TR (1) | TR200001635T2 (hu) |
| WO (1) | WO1999029669A1 (hu) |
| YU (1) | YU35600A (hu) |
| ZA (1) | ZA9811262B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002055497A1 (en) * | 2001-01-15 | 2002-07-18 | Glaxo Group Limited | Aryl piperidine derivatives as inducers of ldl-receptor expression |
| US20040072865A1 (en) * | 2001-01-15 | 2004-04-15 | Bouillot Anne Marie Jeanne | Aryl piperidine derivatives as inducers of ldl-receptor expression |
| JP2004520347A (ja) * | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
| DE10132686A1 (de) * | 2001-07-05 | 2003-01-16 | Boehringer Ingelheim Pharma | Heteroarylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| JP4664634B2 (ja) * | 2003-09-05 | 2011-04-06 | 富山化学工業株式会社 | 新規なベンズアミジン誘導体またはその塩 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04312572A (ja) * | 1991-04-12 | 1992-11-04 | Takeda Chem Ind Ltd | 環状アミン化合物 |
| DE4407136A1 (de) * | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aroyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| DE4407138A1 (de) * | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
-
1997
- 1997-12-10 DE DE19754796A patent/DE19754796A1/de not_active Withdrawn
-
1998
- 1998-12-08 PL PL98341060A patent/PL341060A1/xx unknown
- 1998-12-08 DK DK98962423T patent/DK1060162T3/da active
- 1998-12-08 TR TR2000/01635T patent/TR200001635T2/xx unknown
- 1998-12-08 IL IL13573898A patent/IL135738A0/xx unknown
- 1998-12-08 EA EA200000631A patent/EA200000631A1/ru unknown
- 1998-12-08 AU AU17594/99A patent/AU1759499A/en not_active Abandoned
- 1998-12-08 YU YU35600A patent/YU35600A/sh unknown
- 1998-12-08 EE EEP200000342A patent/EE200000342A/xx unknown
- 1998-12-08 CN CN98811959A patent/CN1281434A/zh active Pending
- 1998-12-08 HU HU0100335A patent/HUP0100335A3/hu unknown
- 1998-12-08 SK SK861-2000A patent/SK8612000A3/sk unknown
- 1998-12-08 JP JP2000524266A patent/JP3418688B2/ja not_active Expired - Fee Related
- 1998-12-08 DE DE59807591T patent/DE59807591D1/de not_active Expired - Fee Related
- 1998-12-08 ES ES98962423T patent/ES2190130T3/es not_active Expired - Lifetime
- 1998-12-08 KR KR1020007006326A patent/KR20010032977A/ko not_active Application Discontinuation
- 1998-12-08 EP EP98962423A patent/EP1060162B1/de not_active Expired - Lifetime
- 1998-12-08 AT AT98962423T patent/ATE234816T1/de not_active IP Right Cessation
- 1998-12-08 WO PCT/EP1998/007965 patent/WO1999029669A1/de not_active Application Discontinuation
- 1998-12-08 BR BR9813495-7A patent/BR9813495A/pt not_active IP Right Cessation
- 1998-12-08 CA CA002309388A patent/CA2309388A1/en not_active Abandoned
- 1998-12-08 PT PT98962423T patent/PT1060162E/pt unknown
- 1998-12-09 CO CO98073126A patent/CO5370694A1/es not_active Application Discontinuation
- 1998-12-09 ZA ZA9811262A patent/ZA9811262B/xx unknown
- 1998-12-09 AR ARP980106228A patent/AR017827A1/es not_active Withdrawn
-
2000
- 2000-06-02 BG BG104500A patent/BG104500A/bg active Pending
- 2000-06-07 HR HR20000377A patent/HRP20000377A2/hr not_active Application Discontinuation
- 2000-06-09 NO NO20002967A patent/NO20002967L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EE200000342A (et) | 2001-08-15 |
| AU1759499A (en) | 1999-06-28 |
| CA2309388A1 (en) | 1999-06-17 |
| AR017827A1 (es) | 2001-10-24 |
| DE59807591D1 (de) | 2003-04-24 |
| NO20002967D0 (no) | 2000-06-09 |
| ES2190130T3 (es) | 2003-07-16 |
| HRP20000377A2 (en) | 2000-12-31 |
| EP1060162B1 (de) | 2003-03-19 |
| BG104500A (bg) | 2001-03-30 |
| EP1060162A1 (de) | 2000-12-20 |
| IL135738A0 (en) | 2001-05-20 |
| CN1281434A (zh) | 2001-01-24 |
| WO1999029669A1 (de) | 1999-06-17 |
| SK8612000A3 (en) | 2000-11-07 |
| DK1060162T3 (da) | 2003-07-14 |
| BR9813495A (pt) | 2000-10-10 |
| NO20002967L (no) | 2000-08-09 |
| JP3418688B2 (ja) | 2003-06-23 |
| CO5370694A1 (es) | 2004-02-27 |
| DE19754796A1 (de) | 1999-06-17 |
| PT1060162E (pt) | 2003-08-29 |
| JP2001525397A (ja) | 2001-12-11 |
| HUP0100335A2 (hu) | 2001-07-30 |
| ZA9811262B (en) | 2000-06-09 |
| EA200000631A1 (ru) | 2000-12-25 |
| YU35600A (sh) | 2002-09-19 |
| ATE234816T1 (de) | 2003-04-15 |
| KR20010032977A (ko) | 2001-04-25 |
| PL341060A1 (en) | 2001-03-26 |
| TR200001635T2 (tr) | 2000-11-21 |
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