IL135738A0 - Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3- epoxysqualene lanesterol cyclase inhibitors - Google Patents

Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3- epoxysqualene lanesterol cyclase inhibitors

Info

Publication number
IL135738A0
IL135738A0 IL13573898A IL13573898A IL135738A0 IL 135738 A0 IL135738 A0 IL 135738A0 IL 13573898 A IL13573898 A IL 13573898A IL 13573898 A IL13573898 A IL 13573898A IL 135738 A0 IL135738 A0 IL 135738A0
Authority
IL
Israel
Prior art keywords
lanesterol
epoxysqualene
azacycloalkanes
thio
production
Prior art date
Application number
IL13573898A
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of IL135738A0 publication Critical patent/IL135738A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Birds (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13573898A 1997-12-10 1998-12-08 Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3- epoxysqualene lanesterol cyclase inhibitors IL135738A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19754796A DE19754796A1 (en) 1997-12-10 1997-12-10 Novel azacycloalkane-derived urethanes, their thio and dithio analogues, their salts, pharmaceutical compositions containing them and their use, and processes for their preparation
PCT/EP1998/007965 WO1999029669A1 (en) 1997-12-10 1998-12-08 Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3 epoxysqualene lanesterol cyclase inhibitors

Publications (1)

Publication Number Publication Date
IL135738A0 true IL135738A0 (en) 2001-05-20

Family

ID=7851381

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13573898A IL135738A0 (en) 1997-12-10 1998-12-08 Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3- epoxysqualene lanesterol cyclase inhibitors

Country Status (27)

Country Link
EP (1) EP1060162B1 (en)
JP (1) JP3418688B2 (en)
KR (1) KR20010032977A (en)
CN (1) CN1281434A (en)
AR (1) AR017827A1 (en)
AT (1) ATE234816T1 (en)
AU (1) AU1759499A (en)
BG (1) BG104500A (en)
BR (1) BR9813495A (en)
CA (1) CA2309388A1 (en)
CO (1) CO5370694A1 (en)
DE (2) DE19754796A1 (en)
DK (1) DK1060162T3 (en)
EA (1) EA200000631A1 (en)
EE (1) EE200000342A (en)
ES (1) ES2190130T3 (en)
HR (1) HRP20000377A2 (en)
HU (1) HUP0100335A3 (en)
IL (1) IL135738A0 (en)
NO (1) NO20002967L (en)
PL (1) PL341060A1 (en)
PT (1) PT1060162E (en)
SK (1) SK8612000A3 (en)
TR (1) TR200001635T2 (en)
WO (1) WO1999029669A1 (en)
YU (1) YU35600A (en)
ZA (1) ZA9811262B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072865A1 (en) * 2001-01-15 2004-04-15 Bouillot Anne Marie Jeanne Aryl piperidine derivatives as inducers of ldl-receptor expression
WO2002055496A1 (en) * 2001-01-15 2002-07-18 Glaxo Group Limited Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression
EP1351937A1 (en) * 2001-01-15 2003-10-15 Glaxo Group Limited Aryl piperidine derivatives as inducers of ldl-receptor expression
DE10132686A1 (en) * 2001-07-05 2003-01-16 Boehringer Ingelheim Pharma Heteroarylcarboxamides, their preparation and their use as medicines
JP4664634B2 (en) * 2003-09-05 2011-04-06 富山化学工業株式会社 Novel benzamidine derivatives or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04312572A (en) * 1991-04-12 1992-11-04 Takeda Chem Ind Ltd Cyclic amine compound
DE4407138A1 (en) * 1994-03-04 1995-09-07 Thomae Gmbh Dr K New (aminomethyl-benzyl(idene))-aza:cycloalkane carbonyl cpds.
DE4407136A1 (en) * 1994-03-04 1995-09-07 Thomae Gmbh Dr K New amino:methyl substd. aroyl-aza:cycloalkane derivs.

Also Published As

Publication number Publication date
ATE234816T1 (en) 2003-04-15
AR017827A1 (en) 2001-10-24
EE200000342A (en) 2001-08-15
YU35600A (en) 2002-09-19
NO20002967D0 (en) 2000-06-09
AU1759499A (en) 1999-06-28
HUP0100335A2 (en) 2001-07-30
DE59807591D1 (en) 2003-04-24
PL341060A1 (en) 2001-03-26
TR200001635T2 (en) 2000-11-21
DK1060162T3 (en) 2003-07-14
CN1281434A (en) 2001-01-24
JP2001525397A (en) 2001-12-11
BR9813495A (en) 2000-10-10
ZA9811262B (en) 2000-06-09
HUP0100335A3 (en) 2001-11-28
WO1999029669A1 (en) 1999-06-17
JP3418688B2 (en) 2003-06-23
CA2309388A1 (en) 1999-06-17
ES2190130T3 (en) 2003-07-16
KR20010032977A (en) 2001-04-25
DE19754796A1 (en) 1999-06-17
NO20002967L (en) 2000-08-09
EP1060162A1 (en) 2000-12-20
HRP20000377A2 (en) 2000-12-31
PT1060162E (en) 2003-08-29
SK8612000A3 (en) 2000-11-07
EP1060162B1 (en) 2003-03-19
BG104500A (en) 2001-03-30
CO5370694A1 (en) 2004-02-27
EA200000631A1 (en) 2000-12-25

Similar Documents

Publication Publication Date Title
PL341231A1 (en) 4(3)-substitute derivatives of 4(3)aminomethyl(thio)pyrane or piperidine derivatives (analogues of garbapentin), their production and application in treating neurological disorders
HUP9800541A3 (en) 1,4-benzothiazepine-1,1-dioxides as hypolipidemics, process for
HUP0100931A3 (en) 6,9-disubstituted 2-[trans-(-aminocyclohexyl)amino]purines and pharmaceutical compositions containing them
IL149005A0 (en) Hexahydrofuro-2', 3-bifuran-3-yl-n-{3'(1, 3-benzodioxol-5-ylsulfonyl) (isobutyl) amino-1-benzyl-2-hydroxypropyl} carbamate as restroviral protease inhibitor
HUP0002122A3 (en) Cyclic thio substituted acylaminoacid amide derivatives
ZA949148B (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
GB0014805D0 (en) Glassbreaker (2)
GR3035170T3 (en) ANALOGUES OF hGH-RH (1-29)NH 2? HAVING ANTAGONISTIC ACTIVITY
IL137329A0 (en) Vla-4 antagonists
IL137518A0 (en) Derivatives of 1,2,4-oxadiazolone
IL134572A0 (en) Substituted 1,2,3,4,5,6-hexahydro-2,6- methano-3-benzazocine-10-oles, methods for the production and use thereof as medicaments
IL135738A0 (en) Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3- epoxysqualene lanesterol cyclase inhibitors
IL141850A (en) High purity composition comprising (7alpha,17alpha)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-3n-20-yn-3-one
OA09192A (en) "Stabilized sulfur dissolving compositions".
GB2355714B (en) Ammonium 3,5-diaminopicrate
SI1060162T1 (en) Urethanes derived from azacycloalkanes, thio and dithio analogues, production and use thereof as 2,3 epoxysqualene lanesterol cyclase inhibitors
HU9400745D0 (en) 2,4-diamino-3-hydroxy-carboxylic acid derivatives
IL127469A0 (en) Modified form of the R (-)-N-(4,4-DI(3-methylthien-s-yl) but-3-enyl)-nipecotic acid hydrochloride
AU1487599A (en) 1,3,4-thiadiazoles derivatives as kyn-oh inhibitors
IL135737A0 (en) Novel urethanes, thio and dithio analogues, the salts thereof, medicaments containing said compounds, use and method for the production thereof
EP1056731A4 (en) Amino acid derivatives of daryl 1,3,4-oxadiazolone
EP0947519A4 (en) Water-base lubricant containing sulfur as coordinate atom, and use thereof
ZA98682B (en) Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more psychiatric disorders
TW353992U (en) Improvement of screwdriver tip making machine
TW328250U (en) Concealed tool screwdriver (2)